CoChat
Sign Up
Cited by 71Orthopaedic implants and arthroplastyOrthopedic Infections and TreatmentsBone Metabolism and Diseases

Synergistic effect of particles and cyclic pressure on cytokine production in human monocyte/macrophages: proposed role in periprosthetic osteolysis

Mevoy, A, Jeyam, M, Ferrier, G, Evans, C.E, Andrew, J.G·2002·Bone
DOI 10.1016/s8756-3282(01)00658-5
Open this paper in CoChat — free account

Abstract

Macrophages, activated by particulate wear debris, are important in the process of osteolysis, which occurs during joint implant loosening. We previously found increased levels of interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha in cultured macrophages subjected to cyclical pressure of 0.138 MPa, suggesting that cyclic pressure may be another relevant cause of macrophage activation. The current study first investigated the effects of a range of cyclic pressures on cultured macrophages, including an investigation of the time course of cytokine expression. At 0.138 MPa, supernatant levels of TNF-alpha were maximal at 12 h, whereas IL-6 and IL-1beta were maximal at 24 h. All four cyclic pressure levels tested (without particles) resulted in increased production of all three cytokines relative to control. These increases were most marked at 0.069 and 0.035 MPa, and the increase in cytokine production at 0.017 MPa was not statistically significant. Further studies demonstrated that conditioned media from cyclically pressurized macrophages stimulated bone resorption in a neonatal mouse calvarial assay system. There were increased levels of calcium released from calvaria cultured in conditioned media from pressurised monocytes, and an increase in tartate-resistant acid phosphatase-positive osteoclasts was observed microscopically. As particulate wear debris is important in implant loosening, ultra high molecular weight polyethylene particles were also added to the…

Integrity signals

Registry

Crossref · 10.1016/s8756-3282(01)00658-5

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The increase in pro-inflammatory cytokine release in response to cyclical pressure and wear debris contributes toward aseptic loosening of implants.

    “The authors proposed that this increase in release of pro-inflammatory cytokines in response to cyclical pressure and presence of wear debris contributes toward aseptic loosening of implants [59].”

    From Biomaterial based modulation of macrophage polarization: a review and suggested design principles (2015) · cites this paper as [59]

  • Cyclical pressure (17-138 kPa) increases pro-inflammatory cytokines (TNF-a, IL-6, IL-1b) in cultured human macrophages compared to controls.

    “Another study quantified the effect of cyclical pressure on cytokine/ chemokine production in cultured human macrophages, with an increase in pro-inflammatory cytokines (TNF-a, IL-6, IL-1b) compared to controls for all levels of cyclical pressures tested (17-138 kPa) [59].”

    From Biomaterial based modulation of macrophage polarization: a review and suggested design principles (2015) · cites this paper as [59]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Mevoy, A., Jeyam, M., Ferrier, G., Evans, C. E., & Andrew, J. G.
Affiliations
University of Manchester (GB)
Corresponding author
Andrew, J.G
Venue
Bone
Publisher
Elsevier BV
Published
2002-01
Volume
30
Issue
1
Pages
171-177
ISSN
  • 1873-2763 (ISSN-L)
  • 8756-3282
DOI
10.1016/s8756-3282(01)00658-5
OpenAlex
W2111664161
Cited by
71
References
36
Citations by year
2023: 1 · 2022: 3 · 2021: 6 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 5 · 2014: 5 · 2013: 5 · 2012: 1
FWCI
4.74
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Bone (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (submittedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Orthopaedic implants and arthroplasty
  • Health Sciences › Medicine › Surgery › Orthopedic Infections and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Keywords
periprosthetic osteolysis, cyclic pressure, macrophage activation, monocytes, wear debris, cytokine production, IL-1β, interleukin-6, TNF-α, bone resorption, aseptic loosening, osteoclasts, implant loosening
MeSH terms
Animals, Atmospheric Pressure, Bone Resorption, Calcium, Humans, Interleukin-1, Macrophage Activation, Macrophages, Monocytes, Osteolysis, Particle Size, Prosthesis Failure, Skull, Tumor Necrosis Factor-alpha, Interleukin-6, Cytokines, Culture Media, Conditioned, Polyethylene, Mice, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review