Mechano-Immunomodulation: Mechanoresponsive Changes in Macrophage Activity and Polarization
Open accessAbstract
In recent years, biomaterial- and scaffold-based immunomodulation strategies were implemented in tissue regeneration efforts for manipulating macrophage polarization (a.k.a. phenotype or lineage commitment, or differentiation). Yet, most of our understanding of macrophage phenotype commitment and phagocytic capacity is limited to how physical cues (extracellular matrix stiffness, roughness, and topography) and soluble chemical cues (cytokines and chemokines released from the scaffold) influence macrophage polarization. In the context of immune response-tissue interaction, the mechanical cues experienced by the residing cells within the tissue also play a critical role in macrophage polarization and inflammatory response. However, there is no compiled study discussing the effect of the dynamic mechanical environment around the tissues on macrophage polarization and the innate immune response. The aim of this comprehensive review paper is 2-fold; (a) to highlight the importance of mechanical cues on macrophage lineage commitment and function and (b) to summarize the important studies dedicated to understand how macrophage polarization changes with different mechanical loading modalities. For the first time, this review paper compiles and compartmentalizes the studies investigating the role of dynamic mechanical loading with various modalities, amplitude, and frequency on macrophage differentiation. A deeper understanding of macrophage phenotype in mechanically dominant tissues (i.e. musculoskeletal tissues, lung tissues, and cardiovascular tissues) provides mechanistic insights into the design of mechano-immunomodulatory tissue scaffold for tissue regeneration.
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The pathologically stiff tissue microenvironment provides topographic cues to embedded cells, causing changes in cellular functions such as morphology and alignment.
“This pathologically stiff tissue microenvironment also provides topographic cues to the embedded cells, causing changes in the cellular functions such as their morphology and alignment (18, 19).”
From Modeling mechanical activation of macrophages during pulmonary fibrogenesis for targeted anti-fibrosis therapy (2024) · cites this paper as [18]
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Flagged first, then by citations
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Sorted by citations
TRPV4 plays a role in matrix stiffness-induced macrophage polarization
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- Authors
- Adams, S., Wuescher, L. M., Worth, R., & Yildirim-Ayan, E.
- Affiliations
- University of Toledo (US)
- University of Toledo Medical Center (US)
- Corresponding author
- Yildirim-Ayan, Eda
- Venue
- Annals of Biomedical Engineering
- Published
- 2019-06-19
- Volume
- 47
- Issue
- 11
- Pages
- 2213-2231
- ISSN
- 0090-6964 (ISSN-L)
- 1573-9686
- PMC
- PMC7043232
- OpenAlex
- W2950647635
- Cited by
- 96
- References
- 115
- Citations by year
- 2026: 12 · 2025: 21 · 2024: 14 · 2023: 11 · 2022: 18 · 2021: 11 · 2020: 7 · 2019: 2
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Update notices
- correction (2019-08-06)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of Biomedical Engineering (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- macrophage polarization, mechanotransduction, dynamic mechanical loading, immunomodulation, macrophage differentiation, phagocytosis, extracellular matrix stiffness, tissue engineering scaffolds, tissue regeneration, musculoskeletal tissue, lung tissue, cardiovascular tissue, innate immune response
- MeSH terms
- Animals, Humans, Immunity, Innate, Macrophages, Stress, Mechanical, Cytokines, Cell Polarity, Mechanotransduction, Cellular, Tissue Scaffolds, Immunomodulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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