Activation of cerebral X-linked adrenoleukodystrophy after head trauma
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Anecdotal cases of head trauma precipitating cALD with inflammatory demyelination beginning at the contusion site have been reported.
“Anecdotical cases of head trauma precipitating cALD have been reported with inflammatory demyelination beginning at the site of the contusion [43,44,45,46].”
From Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy (2025) · cites this paper as [46]
The case description reports cerebral X-ALD developing after head trauma, with new frontal-predominant white matter abnormalities in the region of traumatic microbleeds. The discussion says abnormalities may be most prominent at the site of injury, but does not establish that inflammatory demyelination began at a contusion site; it describes inflammation as a possible mechanism. (LLM, conf=0.85)
Experimental — accuracy not yet measuredTraumatic brain injury has been implicated in a few anecdotal but striking observations of cALD occurrence following head trauma.
“It has been implicated in a few anecdotical but striking observations of cALD occurrence following a head trauma [43,45,46].”
From Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy (2025) · cites this paper as [46]
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Cites
Head trauma can initiate the onset of adreno-leukodystrophy
Raymond, G. V., Seidman, R., Monteith, T. S., Kolodny, E., Sathe, S., Mahmood, A., & Powers, J. M. (2010) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.11.005 · Cited by 90 · see citing works
Dramatic worsening of adult-onset X-linked adrenoleukodystrophy after head trauma
Bouquet, F., Dehais, C., Sanson, M., Lubetzki, C., & Louapre, C. (2015) · Neurology · doi:10.1212/wnl.0000000000002173 · Cited by 19 · see citing works
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Lee, C. A. A., Seo, H. S., Armien, A. G., Bates, F. S., Tolar, J., & Azarin, S. M. (2018) · Fluids and Barriers of the CNS · doi:10.1186/s12987-018-0094-5 · Cited by 52 · see citing works
Deciphering the modifiers for phenotypic variability of X-linked adrenoleukodystrophy
Palakuzhiyil, S. V., Christopher, R., & Chandra, S. R. (2020) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v11.i3.99 · Cited by 24 · see citing works
Pathophysiology of X-Linked Adrenoleukodystrophy: Updates on Molecular Mechanisms
Parasar, P., Kaur, N., & Singh, J. (2024) · Journal of Biotechnology and Biomedicine · doi:10.26502/jbb.2642-91280151 · Cited by 12 · see citing works
Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy
Bougnères, P., & Le Stunff, C. (2025) · Genes · doi:10.3390/genes16050590 · Cited by 11 · see citing works
Initial frontal lobe involvement in adult cerebral X-linked adrenoleukodystrophy
Jiang, W. J., Jin, W., Zhao, H., Huang, D., & Wu, L. (2023) · Acta Neurologica Belgica · doi:10.1007/s13760-023-02295-x · Cited by 3 · see citing works
Therapeutic Strategies for X-Linked Adrenoleukodystrophy, a Representative Peroxisomal Disorder
Morita, M. (2019) · Springer eBooks · doi:10.1007/978-981-15-1169-1_8 · Cited by 2 · see citing works
Peroxisomal ABCD1 deficiency in mice drives Th1 bias through 25-HC–LXR signaling in CD4+ T cells
Maeda, R., Oishi, M., Nagamori, R., Hikosaka‐Kuniishi, M., Watanabe, S., Lee, J., Morita, M., & So, T. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1722647 · Cited by 1 · see citing works
Yamashita, D., Hara, M., Ishii, R., Koike, T., Yuge, K., 藤野, 武., Shimozawa, N., & Yamashita, Y. (2026) · Brain and Development Case Reports · doi:10.1016/j.bdcasr.2026.100152
- Authors
- Budhram, A., & Pandey, S. K.
- Affiliations
- London Health Sciences Centre (CA)
- Corresponding author
- Budhram, Adrian
- Venue
- Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
- Publisher
- Cambridge University Press (CUP)
- Published
- 2017-05-23
- Volume
- 44
- Issue
- 5
- Pages
- 597-598
- ISSN
- 0317-1671 (ISSN-L)
- 2057-0155
- OpenAlex
- W2618628937
- Cited by
- 8
- References
- 2
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2020: 1 · 2019: 1 · 2018: 1
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- X-linked adrenoleukodystrophy, cerebral adrenoleukodystrophy, head trauma, leukodystrophy
- MeSH terms
- Adrenoleukodystrophy, Craniocerebral Trauma, Humans, Magnetic Resonance Imaging, Male, Young Adult
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