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Cited by 86Lipid metabolism and disordersDiabetes, Cardiovascular Risks, and LipoproteinsLipoproteins and Cardiovascular Health

Fasting, non-fasting and postprandial triglycerides for screening cardiometabolic risk

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Keirns, Bryant H., Sciarrillo, Christina M., Koemel, Nicholas A., Emerson, Sam R.·2021·Journal of Nutritional Science
DOI 10.1017/jns.2021.73PMC PMC8453457
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Abstract

Fasting triacylglycerols have long been associated with cardiovascular disease (CVD) and other cardiometabolic conditions. Evidence suggests that non-fasting triglycerides (i.e. measured within 8 h of eating) better predict CVD than fasting triglycerides, which has led several organisations to recommend non-fasting lipid panels as the new clinical standard. However, unstandardised assessment protocols associated with non-fasting triglyceride measurement may lead to misclassification, with at-risk individuals being overlooked. A third type of triglyceride assessment, postprandial testing, is more controlled, yet historically has been difficult to implement due to the time and effort required to execute it. Here, we review differences in assessment, the underlying physiology and the pathophysiological relevance of elevated fasting, non-fasting and postprandial triglycerides. We also present data suggesting that there may be a distinct advantage of postprandial triglycerides, even over non-fasting triglycerides, for early detection of CVD risk and offer suggestions to make postprandial protocols more clinically feasible.

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Cited by

Sorted by citations

Authors
Keirns, B. H., Sciarrillo, C. M., Koemel, N. A., & Emerson, S. R.
Affiliations
  • Oklahoma State University (US)
  • The University of Sydney (AU)
Corresponding author
Keirns, Bryant H.
ORCID
Venue
Journal of Nutritional Science
Publisher
Cambridge University Press (CUP)
Published
2021
Volume
10
Pages
e75-e75
ISSN
2048-6790 (ISSN-L)
DOI
10.1017/jns.2021.73
PMC
PMC8453457
OpenAlex
W3200461153
Cited by
86
References
28
Citations by year
2026: 26 · 2025: 20 · 2024: 14 · 2023: 15 · 2022: 11
FWCI
1.95
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Nutritional Science (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
University of Cambridge
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords
triglycerides, postprandial triglycerides, fasting triglycerides, cardiometabolic risk, cardiovascular risk
MeSH terms
Cardiovascular Diseases, Fasting, Humans, Triglycerides, Postprandial Period

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