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Cited by 249Nitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative MechanismsAtherosclerosis and Cardiovascular Diseases

Postprandial recruitment of neutrophils may contribute to endothelial dysfunction

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van Oostrom, A.J.H.H.M., Sijmonsma, T.P., Verseyden, C., Jansen, E.H.J.M., de Koning, E.J.P., Rabelink, T.J., Castro Cabezas, M.·2003·Journal of Lipid Research
DOI 10.1194/jlr.m200419-jlr200
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Abstract

Atherosclerosis is a low-grade inflammatory disease involving leukocytes, lipids, and glucose leading to endothelial dysfunction. Since activation of neutrophils by triglycerides and glucose has been described in vitro, we hypothesized that the postprandial phase is an inflammatory state affecting leukocytes, possibly contributing to endothelial dysfunction. We measured postprandial blood leukocyte counts, cytokines, hydroperoxides (HPOs), and flow-mediated vasodilation (FMD) in eight healthy males (age 23 +/- 2 years) after a FAT (50 g/m2) and GLUCOSE challenge (37.5 g/m2), a combination of both (MIXED test), and after WATER. All tests, except WATER, resulted in significantly impaired FMD (10% reduction) between t = 1 h and t = 3 h, accompanied by a significant increase of neutrophils (59% after FAT and 28% after GLUCOSE and MIXED), total plasma HPOs (15 to 31% increase), and plasma interleukin-8 (IL-8) (50-130% increase). WATER did not affect FMD, neutrophils, HPOs, or IL-8. Lymphocytes increased gradually in all tests (40-70% increase at t = 10 h compared with t = 0; P < 0.005), paralleling a gradual 3- to 5-fold interleukin-6 increase. Monocyte and erythrocyte counts did not change in any test. In conclusion, the neutrophil increment during postprandial lipemia and glycemia with concomitant IL-8 and HPO increases may contribute to endothelial dysfunction. Lymphocyte increment is a nonspecific diurnal process. Postprandial intravascular inflammatory changes may be relevant for the pathogenesis of atherosclerosis.

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  • Increased abdominal fat mass is associated with chronic elevation of circulating inflammatory mediators including CRP, cytokines, adhesion molecules and pro-thrombotic molecules.

    “The increase in abdominal fat mass is associated with a chronic elevation of the circulating concentrations of inflammatory mediators including several acute-phase inflammatory proteins such as CRP (46,47) , proand anti-inflammatory cytokines, adhesion molecules and pro-thrombotic molecules (22,47 -49) .”

    From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [47]

  • In 10-year-old children, CRP is borderline negatively associated with self-reported physical activity independent of ponderal index.

    “Organised leisure-time exercise (assessed by a questionnaire) in children has shown negative correlations with serum IL-6 concentrations, independently of adiposity and fat localisation (256) , and in 10-year-old children, a borderline significant negative association was observed between CRP and self-reported physical activity, independently of ponderal index (47) .”

    From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [47]

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Authors
van Oostrom, A. J. H. H. M., Sijmonsma, T. P., Verseyden, C., Jansen, E. H. J. M., de Koning, E. J. P., Rabelink, T. J., & Castro Cabezas, M.
Affiliations
  • University Medical Center Utrecht (NL)
  • National Institute for Public Health and the Environment (NL)
ORCID
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
2003-03
Volume
44
Issue
3
Pages
576-583
ISSN
0022-2275 (ISSN-L)
DOI
10.1194/jlr.m200419-jlr200
OpenAlex
W2131142277
Cited by
249
References
54
Citations by year
2026: 2 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 7 · 2021: 4 · 2020: 12 · 2019: 7 · 2018: 7 · 2017: 13 · 2016: 13 · 2015: 14 · 2014: 23 · 2013: 16 · 2012: 9
FWCI
7.28
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Lipid Research (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Rivm Repository (Netherlands National Institute for Public Health and the Environment) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Keywords
postprandial lipemia, postprandial blood glucose, neutrophil recruitment, endothelial dysfunction, atherosclerosis, interleukin-8, interleukin-6, hydroperoxides, flow-mediated dilation, lymphocyte count, glucose challenge test, low-grade inflammation
MeSH terms
Adult, Arteriosclerosis, Blood Glucose, Dietary Fats, Endothelium, Vascular, Fasting, Fatty Acids, Nonesterified, Glucose, Humans, Hydrogen Peroxide, Inflammation, Insulin, Leukocyte Count, Male, Models, Biological, Neutrophils, Time Factors, Triglycerides, Interleukin-6, Interleukin-8, Postprandial Period

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