CoChat
Sign Up
Cited by 15Trace Elements in HealthIron Metabolism and DisordersHeavy Metal Exposure and Toxicity

Response of diamine oxidase and other plasma copper biomarkers to various dietary copper intakes in the rat and evaluation of copper absorption with a stable isotope

Open access
Feillet-Coudray, C., Coudray, C., Bayle, D., Rock, E., Rayssiguier, Y., Mazur, A.·2000·British Journal Of Nutrition
DOI 10.1017/s0007114500000702
Open this paper in CoChat — free accountOpen PDF

Abstract

There is a lack of agreement on index of Cu status and reliable and sensitive biomarkers are still required. The purpose of this present work was to assess in rats the sensitivity of diamine oxidase (DAO) activity, a recently proposed biomarker, to modifications in dietary Cu intake in comparison with other plasma biomarkers of Cu status. We also evaluated the effect of Cu dietary level on Cu and Zn intestinal absorption. Results showed that plasma Cu and plasma caeruloplasmin were significantly decreased at day 8 compared with the control group (7.4 mg Cu/kg diet) while DAO activity was significantly decreased at day 12 of the deficient diet (0.61 mg Cu/kg diet). Cu supplementation (35 mg Cu/kg diet) had no effect on any of the studied biomarkers of Cu status. In Cu-deficient rats plasma Cu and DAO activities were normalized 4 d after return to the control diet while caeruloplasmin was normalized later, at day 11. Apparent absorption values (%) of total Cu or 65Cu isotope were significantly increased in the Cu-deficient rats compared with the other groups and similar in the control and the Cu-supplemented groups. The urinary excretion of total Cu or 65Cu isotope were increased in the Cu-supplemented group compared with the other two groups. Both apparent absorption and urinary excretion of total Zn or 67Zn isotope remained unchanged in the three experimental groups. In conclusion, DAO activity seemed to be less sensitive to Cu deficiency than plasma Cu or caeruloplasmin concentrations. The present study also showed a significant increase in Cu intestinal absorption with dietary Cu restriction but no decrease with Cu supplementation in the rat.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1017/s0007114500000702

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. A Favier, AM Roussel and R Anderson]. New York, NY: Plenum Press.

Cited by

Sorted by citations

Related

Authors
Feillet-Coudray, C., Coudray, C., Bayle, D., Rock, E., Rayssiguier, Y., & Mazur, A.
Affiliations
Centre de Recherche en Nutrition Humaine d'Auvergne (FR)
ORCID
Venue
British Journal Of Nutrition
Publisher
Cambridge University Press (CUP)
Published
2000-05
Volume
83
Issue
5
Pages
561-568
ISSN
  • 0007-1145 (ISSN-L)
  • 1475-2662
DOI
10.1017/s0007114500000702
OpenAlex
W1905790519
Cited by
15
References
38
Citations by year
2026: 1 · 2025: 1 · 2023: 2 · 2021: 1 · 2017: 1 · 2014: 1 · 2013: 1
FWCI
0.66
Type
journal article
Language
en
Open access
Licence
www.cambridge.org/core/terms (unspecified, 2503 d)
Locations
  • British Journal Of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Keywords
diamine oxidase, ceruloplasmin, plasma copper, dietary copper deficiency, copper supplementation, intestinal copper absorption, zinc absorption, urinary copper excretion, stable isotope tracers, copper deficiency
MeSH terms
Absorption, Animals, Ceruloplasmin, Copper, Amine Oxidase (Copper-Containing), Intestinal Absorption, Isotopes, Male, Nutritional Status, Sensitivity and Specificity, Zinc, Zinc Isotopes, Biomarkers, Rats, Wistar, Dietary Supplements, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review