Serum fatty acid composition and indices of stearoyl-CoA desaturase activity are associated with systemic inflammation: longitudinal analyses in middle-aged men
Open accessAbstract
Altered fatty acid (FA) composition is related to insulin resistance and CVD. One possible mediator may be inflammation, but longitudinal data relating FA composition to inflammation taking insulin resistance into account are limited. We investigated the long-term association between FA composition and C-reactive protein (CRP) concentrations in a large population-based cohort study in 767 men followed for 20 years. The association between FA composition in serum cholesteryl esters at age 50 and CRP concentrations at age 70 was investigated using linear regression. In addition, desaturase activities (stearoyl-CoA desaturase-1 (SCD-1), Delta5- and Delta6-desaturase) were estimated using FA product-to-precursor ratios. Insulin resistance was measured directly at follow-up by euglycaemic clamp. After adjusting for confounders (smoking, physical activity, alcohol intake, obesity and erythrocyte sedimentation rate) CRP concentrations were inversely associated with the proportion of 18:2n-6 (P = 0.002) and positively associated with 16:1n-7 (P = 0.008), 18:1n-9 (P = 0.0003), 20:5n-3 (P = 0.04) and estimated SCD-1 (P = 0.005) and Delta6-desaturase (P = 0.02) activities. After adding insulin resistance to the model, 18:1n-9, 18:2n-6 and SCD-1 remained significant predictors of CRP. A FA composition indicating low intake of 18:2n-6, high intake of SFA and high SCD-1 activity is, in a Swedish population of middle-aged men, associated with CRP concentrations 20 years later, even independently of obesity and insulin resistance.
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In vitro, vitamin E exerts a range of anti-inflammatory actions on pro-inflammatory cytokine and eicosanoid production and on adhesive interactions of monocytes with endothelial cells.
“In vitro, vitamin E exerts a range of anti-inflammatory actions with regard to the production of pro-inflammatory cytokines and eicosanoids and adhesive interactions of monocytes with endothelial cells (750,759 -761) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [759]
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References 26 · Cited by 107
- Authors
- Petersson, H., Basu, S., Cederholm, T., & Risérus, U.
- Affiliations
- Uppsala University (SE)
- Corresponding author
- Risérus, Ulf
- Venue
- British Journal Of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2008-06
- Volume
- 99
- Issue
- 6
- Pages
- 1186-1189
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2129516216
- Cited by
- 107
- References
- 26
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 6 · 2022: 1 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 3 · 2015: 10 · 2014: 7 · 2013: 16 · 2012: 13
- FWCI
- 4.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Svenska Sällskapet för Medicinsk Forskning
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- serum fatty acid composition, stearoyl-CoA desaturase 1, desaturase activity, systemic inflammation, C-reactive protein, insulin resistance, omega-6 fatty acids, saturated fatty acids, omega-3 fatty acids, cholesterol esters, middle-aged men, longitudinal cohort
- MeSH terms
- C-Reactive Protein, Fatty Acids, Fatty Acids, Unsaturated, Fatty Acids, Volatile, Humans, Inflammation, Insulin Resistance, Life Style, Longitudinal Studies, Male, Middle Aged, Stearoyl-CoA Desaturase, Sweden, Biomarkers, Multivariate Analysis
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