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Prebiotics, immune function, infection and inflammation: a review of the evidence
Open accessAbstract
Beta2-1 fructans are carbohydrate molecules with prebiotic properties. Through resistance to digestion in the upper gastrointestinal tract, they reach the colon intact, where they selectively stimulate the growth and/or activity of beneficial members of the gut microbiota. Through this modification of the intestinal microbiota, and by additional mechanisms, beta2-1 fructans may have beneficial effects upon immune function, ability to combat infection, and inflammatory processes and conditions. In this paper, we have collated, summarised and evaluated studies investigating these areas. Twenty-one studies in laboratory animals suggest that some aspects of innate and adaptive immunity of the gut and the systemic immune systems are modified by beta2-1 fructans. In man, two studies in children and nine studies in adults indicate that the adaptive immune system may be modified by beta2-1 fructans. Thirteen studies in animal models of intestinal infections conclude a beneficial effect of beta2-1 fructans. Ten trials involving infants and children have mostly reported benefits on infectious outcomes; in fifteen adult trials, little effect was generally seen, although in specific situations, certain beta2-1 fructans may be beneficial. Ten studies in animal models show benefit of beta2-1 fructans with regard to intestinal inflammation. Human studies report some benefits regarding inflammatory bowel disease (four positive studies) and atopic dermatitis (one positive study), but findings in irritable bowel syndrome are inconsistent. Therefore, overall the results indicate that beta2-1 fructans are able to modulate some aspects of immune function, to improve the host's ability to respond successfully to certain intestinal infections, and to modify some inflammatory conditions.
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“The microbiota composition and the related local intestinal metabolism undergoes significant changes in various disease states that are characterised by chronic inflammation, such as inflammatory bowel disease (823) , colorectal cancer and obesity (824,825) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [823]
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Metadata
- Authors
- Lomax, A. R., & Calder, P. C.
- Affiliations
- University of Southampton (GB)
- Corresponding author
- Lomax, Amy R.
- ORCID
- Calder, Philip C.
- Venue
- British Journal Of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2008-09-25
- Volume
- 101
- Issue
- 5
- Pages
- 633-658
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W1991759182
- Cited by
- 257
- References
- 137
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 3 · 2023: 6 · 2022: 18 · 2021: 19 · 2020: 20 · 2019: 20 · 2018: 20 · 2017: 16 · 2016: 14 · 2015: 10 · 2014: 23 · 2013: 17 · 2012: 16
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- prebiotics, gut microbiota, immune function, innate immunity, adaptive immunity, intestinal infection, intestinal inflammation, inflammatory bowel disease, atopic dermatitis, irritable bowel syndrome, infants and children
- MeSH terms
- Adult, Aged, Animals, Child, Child, Preschool, Disease Models, Animal, Female, Fructans, Humans, Immune System, Infant, Infant, Newborn, Inflammation, Intestines, Lymphoid Tissue, Male, Middle Aged, Opportunistic Infections, Evidence-Based Medicine, Young Adult, Prebiotics
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