The DOI matches its Crossref record; 36 of the 37 references it cites were found in a registry or an index.
Expression of Na + /glucose co-transporter 1 (SGLT1) is enhanced by supplementation of the diet of weaning piglets with artificial sweeteners
Open accessAbstract
In an intensive livestock production, a shorter suckling period allows more piglets to be born. However, this practice leads to a number of disorders including nutrient malabsorption, resulting in diarrhoea, malnutrition and dehydration. A number of strategies have been proposed to overcome weaning problems. Artificial sweeteners, routinely included in piglets' diet, were thought to enhance feed palatability. However, it is shown in rodent models that when included in the diet, they enhance the expression of Na + /glucose co-transporter (SGLT1) and the capacity of the gut to absorb glucose. Here, we show that supplementation of piglets' feed with a combination of artificial sweeteners saccharin and neohesperidin dihydrochalcone enhances the expression of SGLT1 and intestinal glucose transport function. Artificial sweeteners are known to act on the intestinal sweet taste receptor T1R2/T1R3 and its partner G-protein, gustducin, to activate pathways leading to SGLT1 up-regulation. Here, we demonstrate that T1R2, T1R3 and gustducin are expressed together in the enteroendocrine cells of piglet intestine. Furthermore, gut hormones secreted by the endocrine cells in response to dietary carbohydrates, glucagon-like peptides (GLP)-1, GLP-2 and glucose-dependent insulinotrophic peptide (GIP), are co-expressed with type 1 G-protein-coupled receptors (T1R) and gustducin, indicating that L- and K-enteroendocrine cells express these taste elements. In a fewer endocrine cells, T1R are also co-expressed with serotonin. Lactisole, an inhibitor of human T1R3, had no inhibitory effect on sweetener-induced SGLT1 up-regulation in piglet intestine. A better understanding of the mechanism(s) involved in sweetener up-regulation of SGLT1 will allow the identification of nutritional targets with implications for the prevention of weaning-related malabsorption.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“In animals, a wide range of sweet stimuli are capable of upregulating SGLT-1 expression and function, including LCS (45-48), indicating that SGLT-1 activity is modulated by an upstream and broadly tuned sweet taste sensor.”
From Gut mechanisms linking intestinal sweet sensing to glycemic control (2018) · cites this paper as [47]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nelson, G., Chandrashekar, J. V., Hoon, M. A., Feng, L., Zhao, G., Ryba, N. J. P., & Zuker, C. S. (2002) · Nature · doi:10.1038/nature726 · Cited by 1,523
Human receptors for sweet and umami taste
Li, X., Staszewski, L. M., Xu, H., Durick, K., Zoller, M. J., & Adler, E. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072090199 · Cited by 1,380
Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.
Jang, H.-J., Kokrashvili, Z., Theodorakis, M. J., Carlson, O. D., Kim, B.-J., Zhou, J., Kim, H. H., Xu, X., Chan, S. L., Juhaszova, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706890104 · Cited by 995 · cited 1×
“Furthermore, in response to natural sugars and artificial sweeteners, enteroendocrine cells secrete GLP-1 and GIP through the activation of sweet taste receptor, indicating the involvement of these gut hormones in SGLT1 up-regulation((8,36)).”
BackgroundT1R3 and gustducin in gut sense sugars to regulate expression of Na + -glucose cotransporter 1
Margolskee, R. F., Dyer, J., Kokrashvili, Z., Salmon, K. S. H., Ilegems, E., Daly, K., Maillet, E. L., Ninomiya, Y., Mosinger, B., & Shirazi-Beechey, S. P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706678104 · Cited by 882
Self-citationElliott, R. M., Morgan, L. M., Tredger, J. A., Deacon, S., Wright, J., & Marks, V. (1993) · Journal of Endocrinology · doi:10.1677/joe.0.1380159 · Cited by 695
Gustducin is a taste-cell-specific G protein closely related to the transducins
McLaughlin, S. K., McKinnon, P. J., & Margolskee, R. F. (1992) · Nature · doi:10.1038/357563a0 · Cited by 676
Detection of Sweet and Umami Taste in the Absence of Taste Receptor T1r3
Damak, S., Rong, M., Yasumatsu, K., Kokrashvili, Z., Varadarajan, V., Zou, S., Jiang, P., Ninomiya, Y., & Margolskee, R. F. (2003) · Science · doi:10.1126/science.1087155 · Cited by 632
Endocrine cells in human intestine: an immunocytochemical study
Sjölund, K., Sandén, G., Håkanson, R., & Sundler, F. (1983) · Gastroenterology · doi:10.1016/s0016-5085(83)80080-8 · Cited by 520
Wu, S.-Z., Rozengurt, N., Yang, M. Y., Young, S. H., Sinnett‐Smith, J. W., & Rozengurt, E. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.042617699 · Cited by 493
A candidate taste receptor gene near a sweet taste locus
Montmayeur, J., Liberles, S. D., Matsunami, H., & Buck, L. B. (2001) · Nature Neuroscience · doi:10.1038/87440 · Cited by 472
Cited by
Sorted by citations
Items 101–114 of 114
Kheder, M. H. (2018) · Queensland University of Technology · doi:10.5204/thesis.eprints.122879 · Cited by 1
Choi, J. (2019) · Mspace (University of Manitoba) · Cited by 1
Lai, S. W. (2014) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/28080 · Cited by 1
Regulation of renal brush-border glucose transport in response to metabolic dysregulation
Chichger, H. (2011) · UCL Discovery (University College London)
German, J. B., Shirazi‐Beechey, S. P., Batchelor, D. J., Al-Rammahi, M. A., Moran, A. W., Brand, J. G., Li, X., & Haskins, M. E. (2011)
Self-citationDamak, S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801694-7.00020-2
Edulcorantes risco cardiovascular
Borges, N. (2012)
Nutritional Strategies to Improve Pig Growth and Performance
Kroscher, K. A. (2020) · VTechWorks (Virginia Tech)
Non-nutritive Sweetened Beverages and Cardiometabolic Risk
McGlynn, N. D. (2020) · TSpace (University of Toronto)
Oral and post-oral factors controlling energy balance in GF rodents
Swartz, T. D., & Covașă, M. (2012) · OpenGrey (Institut de l'Information Scientifique et Technique)
Caractérisation des chimiorécepteurs dans le cerveau
Gaudel, F. (2018) · theses.fr (ABES) · doi:10.70675/5e8ba29az7c6dz47fczbd03z1ff3d9f0c9c9
The role of dietary sugars in intestinal homeostasis and microbiota composition
Zhang, X. (2018) · theses.fr (ABES) · doi:10.70675/bad688b4zdd65z4520zb77cz975f29622456 · Cited by 1
Beyond flavor perception: The role of the taste receptor family in immunity
Ye, N., Wang, B., Cheng, Z., & Cheng, A. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.117184
Nutritional solutions for appetite regulation in livestock and poultry: A review
Liu, X., Yao, R., Song, S., Zhou, C., Wen, L., & Wang, J. (2026) · Animal nutrition · doi:10.1016/j.aninu.2026.03.014
Metadata
- Authors
- Moran, A. W., Al-Rammahi, M. A., Arora, D. K., Batchelor, D. J., Coulter, E. A., Daly, K., Ionescu, C., Bravo, D., & Shirazi-Beechey, S. P.
- Affiliations
- University of Liverpool (GB)
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2010-03-26
- Volume
- 104
- Issue
- 5
- Pages
- 637-646
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2135356931
- Cited by
- 114
- References
- 37
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 1 · 2022: 5 · 2021: 6 · 2020: 7 · 2019: 10 · 2018: 8 · 2017: 8 · 2016: 12 · 2015: 10 · 2014: 8 · 2013: 9 · 2012: 11
- FWCI
- 9.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- reroDoc Digital Library (submittedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- SGLT1, artificial sweeteners, weaning piglets, intestinal glucose transport, saccharin, neohesperidin dihydrochalcone, gustducin, enteroendocrine cells, glucagon-like peptide-1, glucagon-like peptide-2, serotonin, lactisole, gastrointestinal hormones
- MeSH terms
- Animals, Benzene Derivatives, Biological Transport, Dietary Carbohydrates, Glucagon-Like Peptides, Female, Gastric Inhibitory Polypeptide, Hesperidin, Intestine, Small, Male, Saccharin, Serotonin, Sweetening Agents, Swine, Weaning, Transducin, Up-Regulation, Dietary Supplements, Enteroendocrine Cells, Receptors, G-Protein-Coupled, Chalcones, Sodium-Glucose Transporter 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
