Cited by 114Biochemical Analysis and Sensing TechniquesAnimal Nutrition and PhysiologyDiabetes Treatment and Management

The DOI matches its Crossref record; 36 of the 37 references it cites were found in a registry or an index.

Expression of Na + /glucose co-transporter 1 (SGLT1) is enhanced by supplementation of the diet of weaning piglets with artificial sweeteners

Open access

Moran, Andrew W., Al-Rammahi, Miran A., Arora, Daleep K., Batchelor, Daniel J., Coulter, Erin A., Daly, Kristian, Ionescu, Catherine, Bravo, David, Shirazi-Beechey, Soraya P.·2010·British Journal of Nutrition

DOI 10.1017/s0007114510000917

Open this paper in CoChat — free account Open PDF

Abstract

In an intensive livestock production, a shorter suckling period allows more piglets to be born. However, this practice leads to a number of disorders including nutrient malabsorption, resulting in diarrhoea, malnutrition and dehydration. A number of strategies have been proposed to overcome weaning problems. Artificial sweeteners, routinely included in piglets' diet, were thought to enhance feed palatability. However, it is shown in rodent models that when included in the diet, they enhance the expression of Na + /glucose co-transporter (SGLT1) and the capacity of the gut to absorb glucose. Here, we show that supplementation of piglets' feed with a combination of artificial sweeteners saccharin and neohesperidin dihydrochalcone enhances the expression of SGLT1 and intestinal glucose transport function. Artificial sweeteners are known to act on the intestinal sweet taste receptor T1R2/T1R3 and its partner G-protein, gustducin, to activate pathways leading to SGLT1 up-regulation. Here, we demonstrate that T1R2, T1R3 and gustducin are expressed together in the enteroendocrine cells of piglet intestine. Furthermore, gut hormones secreted by the endocrine cells in response to dietary carbohydrates, glucagon-like peptides (GLP)-1, GLP-2 and glucose-dependent insulinotrophic peptide (GIP), are co-expressed with type 1 G-protein-coupled receptors (T1R) and gustducin, indicating that L- and K-enteroendocrine cells express these taste elements. In a fewer endocrine cells, T1R are also co-expressed with serotonin. Lactisole, an inhibitor of human T1R3, had no inhibitory effect on sweetener-induced SGLT1 up-regulation in piglet intestine. A better understanding of the mechanism(s) involved in sweetener up-regulation of SGLT1 will allow the identification of nutritional targets with implications for the prevention of weaning-related malabsorption.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1017/s0007114510000917

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

An amino-acid taste receptor
Nelson, G., Chandrashekar, J. V., Hoon, M. A., Feng, L., Zhao, G., Ryba, N. J. P., & Zuker, C. S. (2002) · Nature · doi:10.1038/nature726 · Cited by 1,523
Human receptors for sweet and umami taste
Li, X., Staszewski, L. M., Xu, H., Durick, K., Zoller, M. J., & Adler, E. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072090199 · Cited by 1,380
Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.
Jang, H.-J., Kokrashvili, Z., Theodorakis, M. J., Carlson, O. D., Kim, B.-J., Zhou, J., Kim, H. H., Xu, X., Chan, S. L., Juhaszova, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706890104 · Cited by 995 · cited 1×
“Furthermore, in response to natural sugars and artificial sweeteners, enteroendocrine cells secrete GLP-1 and GIP through the activation of sweet taste receptor, indicating the involvement of these gut hormones in SGLT1 up-regulation((8,36)).”
Background
T1R3 and gustducin in gut sense sugars to regulate expression of Na + -glucose cotransporter 1
Margolskee, R. F., Dyer, J., Kokrashvili, Z., Salmon, K. S. H., Ilegems, E., Daly, K., Maillet, E. L., Ninomiya, Y., Mosinger, B., & Shirazi-Beechey, S. P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706678104 · Cited by 882
Self-citation
Glucagon-like peptide-1(7–36)amide and glucose-dependent insulinotropic polypeptide secretion in response to nutrient ingestion in man: acute post-prandial and 24-h secretion patterns
Elliott, R. M., Morgan, L. M., Tredger, J. A., Deacon, S., Wright, J., & Marks, V. (1993) · Journal of Endocrinology · doi:10.1677/joe.0.1380159 · Cited by 695
Gustducin is a taste-cell-specific G protein closely related to the transducins
McLaughlin, S. K., McKinnon, P. J., & Margolskee, R. F. (1992) · Nature · doi:10.1038/357563a0 · Cited by 676
Detection of Sweet and Umami Taste in the Absence of Taste Receptor T1r3
Damak, S., Rong, M., Yasumatsu, K., Kokrashvili, Z., Varadarajan, V., Zou, S., Jiang, P., Ninomiya, Y., & Margolskee, R. F. (2003) · Science · doi:10.1126/science.1087155 · Cited by 632
Endocrine cells in human intestine: an immunocytochemical study
Sjölund, K., Sandén, G., Håkanson, R., & Sundler, F. (1983) · Gastroenterology · doi:10.1016/s0016-5085(83)80080-8 · Cited by 520
Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells
Wu, S.-Z., Rozengurt, N., Yang, M. Y., Young, S. H., Sinnett‐Smith, J. W., & Rozengurt, E. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.042617699 · Cited by 493
A candidate taste receptor gene near a sweet taste locus
Montmayeur, J., Liberles, S. D., Matsunami, H., & Buck, L. B. (2001) · Nature Neuroscience · doi:10.1038/87440 · Cited by 472

Show all 37 references

Sorted by citations

Critical review evaluating the pig as a model for human nutritional physiology
Roura, E., Koopmans, S. J., Lallès, J. P., Huërou‐Luron, I. L., de Jager, N., Schuurman, T., & Val‐Laillet, D. (2016) · Nutrition Research Reviews · doi:10.1017/s0954422416000020 · Cited by 323
Metabolic effects of non-nutritive sweeteners
Pepino, M. Y. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.06.024 · Cited by 285
Sucralose affects glycemic and hormonal responses to an oral glucose load
Pepino, M. Y., Tiemann, C. D., Patterson, B. W., Wice, B. M., & Klein, S. (2013) · Diabetes Care · doi:10.2337/dc12-2221 · Cited by 253
Training the Gut for Athletes
Jeukendrup, A. E. (2017) · Sports Medicine · doi:10.1007/s40279-017-0690-6 · Cited by 208
Role of gut nutrient sensing in stimulating appetite and conditioning food preferences
Sclafani, A. J., & Ackroff, K. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00038.2012 · Cited by 201
Sensing of amino acids by the gut-expressed taste receptor T1R1-T1R3 stimulates CCK secretion
Daly, K., Al-Rammahi, M. A., Moran, A. W., Marcello, M., Ninomiya, Y., & Shirazi‐Beechey, S. P. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00074.2012 · Cited by 205
Self-citation
Taste receptors in innate immunity
Lee, R. J., & Cohen, N. A. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1736-7 · Cited by 164
Glucose sensing and signalling; regulation of intestinal glucose transport
Shirazi-Beechey, S. P., Moran, A. W., Batchelor, D. J., Daly, K., & Al-Rammahi, M. (2011) · Proceedings of the Nutrition Society · doi:10.1017/s0029665111000103 · Cited by 139
Self-citation
Intestinal Fructose and Glucose Metabolism in Health and Disease
Merino, B., Fernández-Díaz, C. M., Cózar‐Castellano, I., & Perdomo, G. (2019) · Nutrients · doi:10.3390/nu12010094 · Cited by 147
High-intensity sweetener consumption and gut microbiome content and predicted gene function in a cross-sectional study of adults in the United States
Frankenfeld, C. L., Sikaroodi, M., Lamb, E., Shoemaker, S., & Gillevet, P. M. (2015) · Annals of Epidemiology · doi:10.1016/j.annepidem.2015.06.083 · Cited by 123
The avian taste system: Potential implications in poultry nutrition
Roura, E., Baldwin, M. W., & Klasing, K. C. (2012) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2012.11.001 · Cited by 125
Non-Nutritive Sweeteners and Their Implications on the Development of Metabolic Syndrome
Liauchonak, I., Qorri, B., Dawoud, F., Riat, Y., & Szewczuk, M. R. (2019) · Nutrients · doi:10.3390/nu11030644 · Cited by 126
Extrasensory perception: Odorant and taste receptors beyond the nose and mouth
Foster, S. R., Roura, E., & Thomas, W. G. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.11.004 · Cited by 117
Expression of Na+/glucose co-transporter 1 (SGLT1) in the intestine of piglets weaned to different concentrations of dietary carbohydrate
Moran, A. W., Al-Rammahi, M. A., Arora, D. K., Batchelor, D. J., Coulter, E. A., Ionescu, C., Bravo, D., & Shirazi‐Beechey, S. P. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510000954 · Cited by 109
Self-citation
Resistant starch: Implications of dietary inclusion on gut health and growth in pigs: a review
Tan, F., Beltranena, E., & Zijlstra, R. T. (2021) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-021-00644-5 · Cited by 113
Gut T1R3 sweet taste receptors do not mediate sucrose-conditioned flavor preferences in mice
Sclafani, A. J., Glass, D. S., Margolskee, R. F., & Glendinning, J. I. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00495.2010 · Cited by 93
Sweet taste receptor expression in ruminant intestine and its activation by artificial sweeteners to regulate glucose absorption
Moran, A. W., Al-Rammahi, M. A., Zhang, C., Bravo, D., Calsamiglia, S., & Shirazi‐Beechey, S. P. (2014) · Journal of Dairy Science · doi:10.3168/jds.2014-8004 · Cited by 96
Self-citation
The functional role of the T1R family of receptors in sweet taste and feeding
Treesukosol, Y., Smith, K., & Spector, A. C. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.02.030 · Cited by 95
Role of nutrient-sensing taste 1 receptor (T1R) family members in gastrointestinal chemosensing
Shirazi‐Beechey, S. P., Daly, K., Al-Rammahi, M. A., Moran, A. W., & Bravo, D. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114513002286 · Cited by 90
Self-citation
The Effects of Critical Illness on Intestinal Glucose Sensing, Transporters, and Absorption*
Deane, A. M., Rayner, C. K., Keeshan, A., Cvijanovic, N., Marino, Z., Nguyen, N. Q., Chia, B., Summers, M. J., Sim, J. A., van Beek, T., et al. (2014) · Critical Care Medicine · doi:10.1097/ccm.0b013e318298a8af · Cited by 84
Effects of Food Additives on Immune Cells As Contributors to Body Weight Gain and Immune-Mediated Metabolic Dysregulation
Neto, H. A. P., Ausina, P., Gomez, L. S., Leandro, J. G. B., Zancan, P., & Sola‐Penna, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01478 · Cited by 81
Regulation of intestinal health by branched‐chain amino acids
Zhou, H. W., Yu, B., Gao, J. L., Htoo, J. K. K., & Chen, D. (2017) · Animal Science Journal · doi:10.1111/asj.12937 · Cited by 78
Starch and fiber properties affect their kinetics of digestion and thereby digestive physiology in pigs
Zijlstra, R. T., Jha, R., Woodward, A. D., Fouhse, J. M., & Kempen, T. A. T. G. V. (2012) · Journal of Animal Science · doi:10.2527/jas.53718 · Cited by 75
Food preferences and aversions in human health and nutrition: how can pigs help the biomedical research?
Clouard, C., Meunier‐Salaün, M. C., & Val‐Laillet, D. (2011) · animal · doi:10.1017/s1751731111001315 · Cited by 72
A Subset of Mouse Colonic Goblet Cells Expresses the Bitter Taste Receptor Tas2r131
Prandi, S., Bromke, M., Hübner, S., Voigt, A., Boehm, U., Meyerhof, W., & Behrens, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082820 · Cited by 74
Expression of sweet receptor components in equine small intestine: relevance to intestinal glucose transport
Daly, K., Al-Rammahi, M., Arora, D. K., Moran, A. W., Proudman, C. J., Ninomiya, Y., & Shirazi-Beechey, S. P. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00031.2012 · Cited by 70
Self-citation
Sensing Via Intestinal Sweet Taste Pathways
Young, R. L. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00023 · Cited by 71
Green Fluorescent Protein-Based Glucose Indicators Report Glucose Dynamics in Living Cells
Mita, M., Ito, M., Harada, K., Sugawara, I., Ueda, H., Tsuboi, T., & Kitaguchi, T. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b00447 · Cited by 65
Sugar Reduction in Dairy Food: An Overview with Flavoured Milk as an Example
Mahato, D. K., Keast, R., Liem, D. G., Russell, C. G., Cicerale, S., & Gamlath, S. (2020) · Foods · doi:10.3390/foods9101400 · Cited by 76
Sodium/glucose cotransporter-1, sweet receptor, and disaccharidase expression in the intestine of the domestic dog and cat: two species of different dietary habit
Batchelor, D. J., Al-Rammahi, M. A., Moran, A. W., Brand, J. G., Li, X., Haskins, M. E., German, A. J., & Shirazi‐Beechey, S. P. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00262.2010 · Cited by 60
Self-citation
Cross-Species Comparison of Genes Related to Nutrient Sensing Mechanisms Expressed along the Intestine
van der Wielen, N., van Avesaat, M. H. P., de Wit, N. J. W., Vogels, J., Troost, F. J., Masclee, A., Koopmans, S. J., van der Meulen, J., Boekschoten, M. V., Müller, M. M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107531 · Cited by 61
Gut feedback mechanisms and food intake: a physiological approach to slow carbohydrate bioavailability
Zhang, G., Hasek, L. Y., Lee, B.-H., & Hamaker, B. R. (2015) · Food & Function · doi:10.1039/c4fo00803k · Cited by 55
Effects of isoleucine on glucose uptake through the enhancement of muscular membrane concentrations of GLUT1 and GLUT4 and intestinal membrane concentrations of Na+/glucose co-transporter 1 (SGLT-1) and GLUT2
Zhang, S., Yang, Q., Ren, M., Qiao, S., He, P., Li, D., & Zeng, X. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516002439 · Cited by 54
Bitter, sweet and umami taste receptors and downstream signaling effectors: Expression in embryonic and growing chicken gastrointestinal tract
Cheled-Shoval, S. L., Druyan, S., & Uni, Z. (2015) · Poultry Science · doi:10.3382/ps/pev152 · Cited by 55
The influence of odour, taste and nutrients on feeding behaviour and food preferences in horses
van den Berg, M., Giagos, V., Lee, C., Brown, W. Y., Cawdell-Smith, A. J., & Hinch, G. N. (2016) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2016.08.015 · Cited by 58
COMPARATIVE GUT PHYSIOLOGY SYMPOSIUM: Comparative physiology of digestion1
Furness, J. B., Cottrell, J. J., & Bravo, D. M. (2015) · Journal of Animal Science · doi:10.2527/jas.2014-8481 · Cited by 51
Self-citation
Taste, nutrient sensing and feed intake in pigs (130 years of research: then, now and future)
Roura, E., & Fu, M. (2017) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2017.08.002 · Cited by 50
Carbohydrate Ingestion during Exercise: Effects on Performance, Training Adaptations and Trainability of the Gut
Jeukendrup, A. E., & McLaughlin, J. (2011) · Nestlé Nutrition Institute Workshop Series · doi:10.1159/000329268 · Cited by 46
Peripheral neural targets in obesity
Page, A. J., Symonds, E. L., Peiris, M., Blackshaw, L. A., & Young, R. L. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01951.x · Cited by 43
Characterization of the porcine nutrient and taste receptor gene repertoire in domestic and wild populations across the globe
da Silva, E. C., de Jager, N., Burgos-Paz, W. O., Reverter, A., Miguel Pérez-enciso, A., & Roura, E. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-1057 · Cited by 43
Gut mechanisms linking intestinal sweet sensing to glycemic control
Kreuch, D., Keating, D. J., Wu, T., Horowitz, M., Rayner, C. K., & Young, R. L. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00741 · Cited by 40
The impact of low and no-caloric sweeteners on glucose absorption, incretin secretion, and glucose tolerance
Chan, C. B., Hashemi, Z., & Subhan, F. B. (2017) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0705 · Cited by 39
Review: Chemosensing of nutrients and non-nutrients in the human and porcine gastrointestinal tract
Roura, E., Depoortere, I., & Navarro, M. (2019) · animal · doi:10.1017/s1751731119001794 · Cited by 39
Detecting thresholds for bitter, umami, and sweet tastants in broiler chicken using a 2-choice test method
Cheled-Shoval, S. L., Reicher, N., Niv, M. Y., & Uni, Z. (2017) · Poultry Science · doi:10.3382/ps/pex003 · Cited by 38
The Effects of Non-Nutritive Sweetener Consumption in the Pediatric Populations: What We Know, What We Don’t, and What We Need to Learn
Shum, B. J., & Georgia, S. K. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.625415 · Cited by 40
Nutrient sensing of gut luminal environment
Moran, A. W., Daly, K., Al-Rammahi, M. A., & Shirazi‐Beechey, S. P. (2020) · Proceedings of The Nutrition Society · doi:10.1017/s0029665120007120 · Cited by 38
Self-citation
DIGESTIVE PHYSIOLOGY OF THE PIG SYMPOSIUM: Gut chemosensing and the regulation of nutrient absorption and energy supply1
Mace, O. J., & Marshall, F. H. (2012) · Journal of Animal Science · doi:10.2527/jas.2012-5906 · Cited by 37
Glucagon-like peptide 2 and its beneficial effects on gut function and health in production animals
Connor, E. E., Evock-Clover, C. M., Wall, E. H., Baldwin, R. L., Santı́n, M., Elsasser, T. H., & Bravo, D. M. (2016) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2015.11.008 · Cited by 34
Self-citation
NONRUMINANT NUTRITION SYMPOSIUM: Intestinal glucose sensing and regulation of glucose absorption: Implications for swine nutrition1
Shirazi‐Beechey, S. P., Moran, A. W., Bravo, D., & Al-Rammahi, M. A. (2011) · Journal of Animal Science · doi:10.2527/jas.2010-3695 · Cited by 32
Self-citation
Effects of Sucralose Ingestion versus Sucralose Taste on Metabolic Responses to an Oral Glucose Tolerance Test in Participants with Normal Weight and Obesity: A Randomized Crossover Trial
Nichol, A. D., Salamé, C., Rother, K. I., & Pepino, M. Y. (2019) · Nutrients · doi:10.3390/nu12010029 · Cited by 34
Low calorie sweeteners: Evidence remains lacking for effects on human gut function
Bryant, C. E., & McLaughlin, J. T. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.04.026 · Cited by 30
Dietary supplementation with rumen-protected capsicum during the transition period improves the metabolic status of dairy cows
Oh, J., Harper, M. T., Audino Melgar, M., Räisänen, S. E., Chen, X., Nedelkov, K., Fetter, M. E., OTT, T. L., Wall, E. H., & Hristov, A. N. (2021) · Journal of Dairy Science · doi:10.3168/jds.2020-19892 · Cited by 30
Influence of age and Enterococcus faecium NCIMB 10415 on development of small intestinal digestive physiology in piglets
Martin, L., Pieper, R., Kröger, S., Boroojeni, F. G., Vahjen, W., Neumann, K., Kessel, A. G. V., & Zentek, J. (2012) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2012.04.002 · Cited by 30
Foregut exclusion disrupts intestinal glucose sensing and alters portal nutrient and hormonal milieu
Pal, A., Rhoads, D. B., & Tavakkoli, A. (2015) · Diabetes · doi:10.2337/db14-1578 · Cited by 29
Nutrient-Sensing Biology in Mammals and Birds
Roura, E., & Foster, S. R. (2017) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-030117-014740 · Cited by 26
Non-nutritive Sweeteners and Glycaemic Control
Kim, Y., Keogh, J. B., & Clifton, P. M. (2019) · Current Atherosclerosis Reports · doi:10.1007/s11883-019-0814-6 · Cited by 30
Impact of Citrus Pulp or Inulin on Intestinal Microbiota and Metabolites, Barrier, and Immune Function of Weaned Piglets
Uerlings, J., Sureda, E. A., Schroyen, M., Kroeske, K., Tanghe, S., Vos, M. D., Bruggeman, G., Wavreille, J., Bindelle, J., Purcaro, G., et al. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.650211 · Cited by 24
Consumption of a Beverage Containing Aspartame and Acesulfame K for Two Weeks Does Not Adversely Influence Glucose Metabolism in Adult Males and Females: A Randomized Crossover Study
Kim, Y., Keogh, J. B., & Clifton, P. M. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17239049 · Cited by 24
Expression and regulation of α‐transducin in the pig gastrointestinal tract
Mazzoni, M., GIORGIO, R. D., Latorre, R., Vallorani, C., Bosi, P., Trevisi, P., Barbara, G., Stanghellini, V., Corinaldesi, R., Forni, M., et al. (2013) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12026 · Cited by 23
Gut chemosensing: implications for disease pathogenesis
Berg, C. J., & Kaunitz, J. D. (2016) · F1000Research · doi:10.12688/f1000research.9208.1 · Cited by 22
Sensation of dietary nutrients by gut taste receptors and its mechanisms
Xie, F., Shen, J., Liu, T., Zhou, M., Johnston, L. J., Zhao, J., Zhang, H., & Ma, X. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.2021388 · Cited by 24
Physiological and metabolic control of diet selection
Roura, E., & Navarro, M. (2018) · Animal Production Science · doi:10.1071/an16775 · Cited by 24
Dietary starch breakdown product sensing mobilizes and apically activates α‐glucosidases in small intestinal enterocytes
Chegeni, M., Amiri, M., Nichols, B. L., Nairn, H. Y., & Hamaker, B. R. (2018) · The FASEB Journal · doi:10.1096/fj.201701029r · Cited by 22
DIGESTIVE PHYSIOLOGY OF THE PIG SYMPOSIUM: G protein-coupled receptors in nutrient chemosensation and gastrointestinal hormone secretion1
Liou, A. P. (2012) · Journal of Animal Science · doi:10.2527/jas.2012-5910 · Cited by 21
Oral and intestinal sweet and fat tasting: impact of receptor polymorphisms and dietary modulation for metabolic disease
Cvijanovic, N., Feinle‐Bisset, C., Young, R. L., & Little, T. J. (2015) · Nutrition Reviews · doi:10.1093/nutrit/nuu026 · Cited by 20
Lipid-Lowering Pharmaceutical Clofibrate Inhibits Human Sweet Taste
Kochem, M., & Breslin, P. A. S. (2016) · Chemical Senses · doi:10.1093/chemse/bjw104 · Cited by 19
Non-nutritive sweetener activation of the pig sweet taste receptor T1R2-T1R3 in vitro mirrors sweetener stimulation of the gut-expressed receptor in vivo
Daly, K., Moran, A. W., Al-Rammahi, M. A., Weatherburn, D., & Shirazi‐Beechey, S. P. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.01.032 · Cited by 19
Self-citation
Glucosensing in liver and Brockmann bodies of rainbow trout through glucokinase-independent mechanisms
Otero-Rodiño, C., Librán-Pérez, M., Velasco, C., Álvarez‐Otero, R., López‐Patiño, M. A., Míguez, J. M., & Soengas, J. L. (2015) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2015.09.008 · Cited by 17
Enteroendocrine profile of α-transducin immunoreactive cells in the gastrointestinal tract of the European sea bass (Dicentrarchus labrax)
Latorre, R., Mazzoni, M., GIORGIO, R. D., Vallorani, C., Bonaldo, A., Gatta, P. P., Corinaldesi, R., Ruggeri, E., Bernardini, C., Chiocchetti, R., et al. (2013) · Fish Physiology and Biochemistry · doi:10.1007/s10695-013-9808-4 · Cited by 17
Safety and efficacy of sodium saccharin when used as a feed flavour for piglets, pigs for fattening, calves for rearing and calves for fattening
(FEEDAP), E. P. O. A. A. P. O. S. U. I. A. F., Rychen, G., Aquilina, G., Azimonti, G., Bampidis, V., Bastos, M. D. L., Bories, G. F., Cocconcelli, P. S., Flachowsky, G., Gropp, J., et al. (2018) · EFSA Journal · doi:10.2903/j.efsa.2018.5208 · Cited by 17
Low-calorie sweeteners augment tissue-specific insulin sensitivity in a large animal model of obesity
Malbert, C., Horowitz, M., & Young, R. L. (2019) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-019-04430-4 · Cited by 17
Taste Receptor Gene Expression Outside the Gustatory System
Behrens, M., Prandi, S., & Meyerhof, W. (2014) · Topics in medicinal chemistry · doi:10.1007/7355_2014_79 · Cited by 16
Effects of pre-exercise sucralose ingestion on carbohydrate oxidation during exercise
Stellingwerff, T., Godin, J.-P., Beaumont, M., Tavenard, A., Grathwohl, D., van Bladeren, P. J., Kapp, A.-F., Coutre, J. L., & Damak, S. (2013) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.23.6.584 · Cited by 15
Regulation of α-Transducin and α-Gustducin Expression by a High Protein Diet in the Pig Gastrointestinal Tract
GIORGIO, R. D., Mazzoni, M., Vallorani, C., Latorre, R., Bombardi, C., Bacci, M. L., Forni, M., Falconi, M., Sternini, C., & Clavenzani, P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148954 · Cited by 15
Supplementation with artificial sweetener and capsaicin alters metabolic flexibility and performance in heat-stressed and feed-restricted pigs
Kroscher, K. A., Fausnacht, D. W., McMillan, R. P., El‐Kadi, S. W., Wall, E. H., Bravo, D. M., & Rhoads, R. P. (2022) · Journal of Animal Science · doi:10.1093/jas/skac195 · Cited by 14
Self-citation
Consumption of a Natural High-Intensity Sweetener Enhances Activity and Expression of Rabbit Intestinal Na+/Glucose Cotransporter 1 (SGLT1) and Improves Colibacillosis-Induced Enteric Disorders
Moran, A. W., Al-Rammahi, M. A., Daly, K., Grand, E., Ionescu, C., Bravo, D. M., Wall, E. H., & Shirazi‐Beechey, S. P. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b04995 · Cited by 15
Self-citation
Taste receptor T1R3 regulates testosterone synthesis via the cAMP-PKA-SP1 pathway in testicular Leydig cells
Liu, W., wang, H., Mu, Q., & Gong, T. (2024) · Theriogenology · doi:10.1016/j.theriogenology.2024.10.019 · Cited by 13
Feed preference in pigs: Relationship between cereal preference and nutrient composition and digestibility1
Solà‐Oriol, D., Roura, E., & Torrallardona, D. (2013) · Journal of Animal Science · doi:10.2527/jas.2013-6791 · Cited by 15
Nutrient Sensing for the Future of Land-Farmed Animal and Aquaculture Nutrition
Gao, Z., Liu, C., Mai, K., & He, G. (2022) · Engineering · doi:10.1016/j.eng.2022.05.019 · Cited by 13
In vitro evidence in rainbow trout supporting glucosensing mediated by sweet taste receptor, LXR, and mitochondrial activity in Brockmann bodies, and sweet taste receptor in liver
Otero-Rodiño, C., Velasco, C., Álvarez‐Otero, R., López‐Patiño, M. A., Míguez, J. M., & Soengas, J. L. (2016) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2016.04.010 · Cited by 12
Effect of a long-term exposure to concentrated sucrose and maltodextrin solutions on the preference, appetence, feed intake and growth performance of post-weaned piglets
Guzmán-Pino, S. A., Solà‐Oriol, D., Figueroa, J., Dwyer, D. M., & Pérez, J. F. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.01.009 · Cited by 12
Beyond sweetness: The high-intensity sweeteners and farm animals
Chen, J., Lei, Y., Zhang, Y., He, S., Liu, L., & Dong, X. (2020) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2020.114571 · Cited by 12
Gastrointestinal taste receptors: could tastants become drugs?
Behrens, M., & Somoza, V. (2020) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000531 · Cited by 10
Calf intestinal health: Assessment and dietary interventions for its improvement
Marquez, J. C. (2014) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign) · Cited by 9
Effects of Nonnutritive Sweeteners on Body Composition Changes during Pubertal Growth
Chien, Y.-H., Lin, C., Hsu, S., Chen, Y., Wu, H., Huang, S.-W., & Chen, Y. (2023) · Nutrients · doi:10.3390/nu15102319 · Cited by 8
Forage taste agents modifying yak grazing decrease soil microbial diversity in alpine meadow
You, Y., Ren, J., Wu, J., Ma, Z., Gu, Y., Wang, Y., Wang, Z., Bowatte, S., Zhou, Q., & Hou, F. (2021) · Applied Soil Ecology · doi:10.1016/j.apsoil.2021.104160 · Cited by 8
Sucrose Inclusion in Gestating and Lactating Diets of Sows Modifies the Feeding Behavior of Post-Weaning Pigs for Sweet Solutions
Figueroa, J., Valenzuela, C., V, & Guzmán-Pino, S. A. (2022) · Veterinary Sciences · doi:10.3390/vetsci9050233 · Cited by 7
The Combination of Plant Extracts and Probiotics Improved Jejunal Barrier and Absorption Capacity of Weaned Piglets
Yang, L., Ma, X., Yang, C., Jiang, S., Yang, W., & Jiang, S. (2022) · Agriculture · doi:10.3390/agriculture12070912 · Cited by 7
Session 3: Influences of food constituents on gut health Glucose sensing and signalling; regulation of intestinal glucose transport
Shirazi‐Beechey, S. P., Moran, A. W., Batchelor, D. J., Daly, K., & Al-Rammahi, M. A. (2011) · Cited by 6
Self-citation
Signalling from the gut lumen
Furness, J. B., & Cottrell, J. J. (2017) · Animal Production Science · doi:10.1071/an17276 · Cited by 6
Evaluating the Effects of Non-Nutritive Sweeteners on Pigs: A Systematic Review
Jansen, M., & Kim, K. (2024) · Animals · doi:10.3390/ani14203032 · Cited by 4
Host or the Hosted? Effects of Non-Nutritive Sweeteners on Intestinal and Microbial Mechanisms of Glycemic Control
Rose, B. D., Pezos, N., Choo, J. M., Wu, T., Rogers, G. B., Ivey, K. L., Rayner, C. K., & Young, R. L. (2024) · Nutrients · doi:10.3390/nu16213628 · Cited by 3
Dietary 18β-Glycyrrhetinic Acid Supplementation Improves Intestinal Function and Gut Microbiota in D-Galactose–Challenged Weanling Pigs
Ma, C., Wang, F., Li, R., Huang, K., Zhao, Q., Qin, Y., Zhang, J., & Si, W. (2025) · Journal of Nutrition · doi:10.1016/j.tjnut.2025.11.025 · Cited by 2
Enzyme activity and phosphate uptake in the small intestine of Sprague Dawley rats improved by supplementation of infant formula with prebiotics
Zhou, S., Hang, Y., Wang, J., & Fang, R. (2018) · Animal nutrition · doi:10.1016/j.aninu.2018.06.003 · Cited by 2
Chapter 8 Dietary fibre, gut sensing and modulation of feed intake in pigs and chickens
Roura, E. (2019) · Wageningen Academic Publishers eBooks · doi:10.3920/978-90-8686-893-3_8 · Cited by 3
The Effect of Supplementing Sodium Butyrate Containing Feed with Glutamine and/or Glucose on the Structure of the Piglet Digestive Tract and Selected Blood Indices
Hańczakowska, E., Niwińska, B., GRELA, E. R., Węglarzy, K., & Okoń, K. (2016) · Annals of Animal Science · doi:10.1515/aoas-2016-0039 · Cited by 1
Determination of sweetener specificity of horse gut-expressed sweet taste receptor T1R2-T1R3 and its significance for energy provision and hydration
Smith, L., Moran, A. W., Al-Rammahi, M. A., Daly, K., & Shirazi‐Beechey, S. P. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1325135 · Cited by 3
Self-citation
Using Animal Models to Determine the Role of Gustatory Neural Input in the Control of Ingestive Behavior and the Maintenance of Body Weight
Ciullo, D., & Dotson, C. (2015) · Chemosensory Perception · doi:10.1007/s12078-015-9190-y · Cited by 1
Efficacy of butyrate-producing therapies for use in pediatric intestinal failure
Barnes, J. L. (2013) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign) · Cited by 1
Az energiamentes édesítőszerek alkalmazásának hatása klinikai vizsgálatok, in vitro és állatkísérletek eredményei alapján
Szűcs, Z., Ábel, T., & Lengyel, G. (2016) · Orvosi Hetilap · doi:10.1556/oh.2016.30466 · Cited by 1

Authors: Moran, A. W., Al-Rammahi, M. A., Arora, D. K., Batchelor, D. J., Coulter, E. A., Daly, K., Ionescu, C., Bravo, D., & Shirazi-Beechey, S. P.
Affiliations: University of Liverpool (GB)
ORCID: Moran, Andrew W.
Al-Rammahi, Miran A.
Batchelor, Daniel J.
Daly, Kristian
Ionescu, Catherine
Venue: British Journal of Nutrition
Publisher: Cambridge University Press (CUP)
Published: 2010-03-26
Volume: 104
Issue: 5
Pages: 637-646
ISSN: 0007-1145 (ISSN-L)
1475-2662
DOI: 10.1017/s0007114510000917
OpenAlex: W2135356931
Cited by: 114
References: 37
Citations by year: 2026: 2 · 2025: 1 · 2024: 4 · 2023: 1 · 2022: 5 · 2021: 6 · 2020: 7 · 2019: 10 · 2018: 8 · 2017: 8 · 2016: 12 · 2015: 10 · 2014: 8 · 2013: 9 · 2012: 11
FWCI: 9.71
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified)
Locations: British Journal Of Nutrition (publishedVersion)
PubMed (publishedVersion)
reroDoc Digital Library (submittedVersion)
Funders: Biotechnology and Biological Sciences Research Council
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: SGLT1, artificial sweeteners, weaning piglets, intestinal glucose transport, saccharin, neohesperidin dihydrochalcone, gustducin, enteroendocrine cells, glucagon-like peptide-1, glucagon-like peptide-2, serotonin, lactisole, gastrointestinal hormones
MeSH terms: Animals, Benzene Derivatives, Biological Transport, Dietary Carbohydrates, Glucagon-Like Peptides, Female, Gastric Inhibitory Polypeptide, Hesperidin, Intestine, Small, Male, Saccharin, Serotonin, Sweetening Agents, Swine, Weaning, Transducin, Up-Regulation, Dietary Supplements, Enteroendocrine Cells, Receptors, G-Protein-Coupled, Chalcones, Sodium-Glucose Transporter 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Expression of Na + /glucose co-transporter 1 (SGLT1) is enhanced by supplementation of the diet of weaning piglets with artificial sweeteners

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks