Rice endosperm protein slows progression of fatty liver and diabetic nephropathy in Zucker diabetic fatty rats
Open accessAbstract
We previously reported that rice endosperm protein (REP) has renoprotective effects in Goto-Kakizaki rats, a non-obese diabetic model. However, whether these effects occur in obese diabetes remains unclear. This study aimed to clarify the effects of REP on obese diabetes, especially on fatty liver and diabetic nephropathy, using the obese diabetic model Zucker diabetic fatty (ZDF) rats. In total, 7-week-old male ZDF rats were fed diets containing 20 % REP or casein (C) for 8 weeks. Changes in fasting blood glucose levels and urinary markers were monitored during the experimental period. Hepatic lipids and metabolites were measured and renal glomeruli were observed morphologically. HbA1c levels were significantly lower in rats fed REP, compared with C (P<0·05). Compared with C in the liver, REP prevented lipid accumulation (total lipid, TAG and total cholesterol, P<0·01). Liver metabolome analysis indicated that levels of metabolites associated with glycolysis, the pentose phosphate pathway and carnitine metabolism were significantly greater in the REP group than in the C group (P<0·05), suggesting activation of both glucose catabolism and fatty acid oxidation. The metabolite increases promoted by REP may contribute to suppression of liver lipid accumulation. Urinary excretion of albumin and N-acetyl-β-d-glucosaminidase was significantly reduced in rats fed REP for 8 weeks (P<0·01). In addition, there was a distinct suppression of mesangial matrix expansion and glomerular hypertrophy in response to REP (P<0·01). Thus, REP had preventive effects on obese diabetes, fatty liver and diabetic nephropathy.
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Rice endosperm protein is high in arginine, a precursor of nitric oxide, which is depleted in the diabetic rat model.
“Another potential explanation is that a protein such as rice endosperm protein is high in arginine, a precursor of nitric oxide (NO), which is depleted in this rat model [105,106].”
From Plant Proteins: Assessing Their Nutritional Quality and Effects on Health and Physical Function (2020) · cites this paper as [105]
Plant-based proteins from soybean and rice endosperm have demonstrated renal protective properties in diabetic rat models.
“The plant-based proteins from soybean and rice endosperm have demonstrated renal protective properties in diabetic rat models [105].”
From Plant Proteins: Assessing Their Nutritional Quality and Effects on Health and Physical Function (2020) · cites this paper as [105]
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Plant Proteins: Assessing Their Nutritional Quality and Effects on Health and Physical Function
Hertzler, S. R., Lieblein-Boff, J. C., Weiler, M., & Allgeier, C. (2020) · Nutrients · doi:10.3390/nu12123704 · Cited by 594 · see citing works
- Authors
- Kubota, M., Watanabe, R., Yamaguchi, M., Hosojima, M., Saito, A., Fujii, M., Fujimura, S., & Kadowaki, M.
- Affiliations
- Niigata University (JP)
- University of Niigata Prefecture (JP)
- Kameda Seika Co., Ltd. (Japan) (JP)
- Corresponding author
- Kubota, Masatoshi
- Venue
- British Journal Of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2016-10-11
- Volume
- 116
- Issue
- 8
- Pages
- 1326-1335
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2530487514
- Cited by
- 25
- References
- 46
- Citations by year
- 2024: 5 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 4 · 2017: 3 · 2016: 1
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (16K00855, 26461216, 26292066)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- hepatic steatosis, diabetic nephropathy, Zucker diabetic fatty rats, hepatic lipid accumulation, liver metabolome, glycolysis, pentose phosphate pathway, carnitine metabolism, fatty acid oxidation, albuminuria, N-acetyl-beta-D-glucosaminidase, mesangial expansion, glomerular hypertrophy, HbA1c, dietary protein
- MeSH terms
- Hypoadrenocorticism, Familial, Animals, Carbohydrate Metabolism, Inborn Errors, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Energy Metabolism, Glycerol Kinase, Kidney Glomerulus, Liver, Male, Obesity, Organ Size, Rats, Zucker, Oryza, Plant Proteins, Dietary, Diet, Vegetarian, Biomarkers, Weight Gain, Disease Progression, Lipid Metabolism, Renal Insufficiency, Chronic, Hyperphosphatemia, Endosperm, Non-alcoholic Fatty Liver Disease
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