The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
DGAT1 polymorphism in Bos indicus and Bos taurus cattle breeds
Abstract
As a result of multiple QTL-mapping projects in recent years, a quantitative trait locus for milk fat percentage and milk yield has been described on BTA14. Recent reports name the acyl-CoA : diacylglycerol acyltransferase (DGAT1) gene on BTA14 as a potential candidate gene, with a nonconservative substitution of lysine by alanine (K232A) producing a major effect on milk composition and yield. DGAT1K appears to be the ancestral allele and the K232A substitution probably occurred after the divergence of the Bos indicus and Bos taurus lineages. These findings prompted us to genotype 1748 DNA samples of 38 different Bos taurus and Bos indicus cattle breeds from 13 countries on five continents (Europe, Africa, Asia, North America and South America), to examine the occurrence of the DGAT1 polymorphism and characterize the K232A substitution in cattle breeds of different origins and selected for different purposes (e.g., beef, dairy and dual purpose). Calculating pairwise FST values for pooled subpopulations showed least divergence for Bos indicus breeds with high milk fat percentage. Fixation of DGAT1A was found in some Bos taurus breeds and fixation of DGAT1K in one Bos indicus breed. Breeds of no known organized breeding background from the Near East domestication centre of Bos taurus and taurine African N'Dama cattle were found to possess intermediate frequencies of DGAT1K. While beef breeds tended to harbour higher DGAT1A levels, dairy cattle showed everything from very low levels of DGAT1K to unexpectedly high frequencies of this allele.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Haplotype analysis has shown that taurine breeds carry a high frequency of the DGAT1 A haplotype, while zebu breeds possess a high proportion of the K haplotype [154,155].”
From The Genomic Landscape of Cattle: Domestication, Dispersal, and Adaptive Evolution (2026) · cites this paper as [155]
Citations
Cites
A simple salting out procedure for extracting DNA from human nucleated cells
Miller, S. A., Dykes, D. D., & Polesky, H. F. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.3.1215 · Cited by 20,341
GENEPOP (version 1.2): population genetic software for exact tests and ecumenicism
Raymond, M., & Rousset, F. (1995) · Journal of Heredity · doi:10.1093/oxfordjournals.jhered.a111573 · Cited by 16,187
(1995) · Elsevier eBooks · doi:10.1016/b978-0-12-384430-9.x5000-8 · Cited by 1,153
F ‐statistics and analysis of gene diversity in subdivided populations
Nei, M. (1977) · Annals of Human Genetics · doi:10.1111/j.1469-1809.1977.tb01918.x · Cited by 1,126
Grisart, B., Coppieters, W. R., Farnir, F., Karim, L., Ford, C., Berzi, P., Cambisano, N., Mni, M., Reid, S., Simon, P., et al. (2002) · Genome Research · doi:10.1101/gr.224202 · Cited by 992
Evidence for Two Independent Domestications of Cattle
Loftus, R. T., MacHugh, D. E., Bradley, D. G., Sharp, P. M., & Cunningham, P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.7.2757 · Cited by 812
Genetic Evidence for Near-Eastern Origins of European Cattle
Troy, C. S., MacHugh, D. E., Bailey, J. F., Magee, D. A., Loftus, R. T., Cunningham, P., Chamberlain, A. T., Sykes, B. C., & Bradley, D. G. (2001) · Nature · doi:10.1038/35074088 · Cited by 627
MacHugh, D. E., Shriver, M. D., Loftus, R. T., Cunningham, P., & Bradley, D. G. (1997) · Genetics · doi:10.1093/genetics/146.3.1071 · Cited by 547
A second-generation linkage map of the bovine genome.Preprint
Kappes, S. M., Keele, J. W., STONE, R. T., McGraw, R. A., Sonstegard, T. S., Smith, T. P. L., Lopez-Corrales, N. L., & Beattie, C. W. (1997) · Genome Research · doi:10.1101/gr.7.3.235 · Cited by 522
Winter, A., Krämer, W., Werner, F. A. O., Kollers, S., Kata, S. R., Durstewitz, G., Buitkamp, J., Womack, J. E., Thaller, G. E., & Fries, R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.142293799 · Cited by 404
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–123 of 123
Sodhi, M., Verma, P., Bharti, V. K., Kumar, P., Giri, A., Kumari, P., Gagoi, D., Sharma, A., MANN, S., & Mukesh, M. (2021) · The Indian Journal of Animal Sciences · doi:10.56093/ijans.v90i11.111509 · Cited by 2
Işık, R., & Özdïl, F. (2018) · Journal of Equine Veterinary Science · doi:10.1016/j.jevs.2018.11.012 · Cited by 2
Mapping Quantitative Trait Loci
Weller, J. I. (2012) · Wiley eBooks · doi:10.1002/9781118301739.ch12 · Cited by 2
Short communication: Analysis of polymorphisms in candidate’s genes for meat quality in Lidia cattle
Pelayo, R., Valera, M., Molina, A., & Avilés, C. (2016) · Spanish Journal of Agricultural Research · doi:10.5424/sjar/2016144-9279 · Cited by 1
Ardıçlı, S. (2021) · Open Veterinary Science · doi:10.1515/ovs-2020-0112 · Cited by 1
Jaime Piñeira, V., Río, J., Floody, H., & Felmer, R. N. (2012) · Archivos de medicina veterinaria · doi:10.4067/s0301-732x2012000100007 · Cited by 1
Der Effekt von DGAT1-Genvarianten in Deutschen Holstein- Kühen unter Produktionsbedingungen
Rahmatalla, S. A. (2015) · Cited by 1
Gürsel, F. E., Akış, I., Ateş, A., Yardibi, H., Hoştürk, G. T., & ÖZTABAK, K. Ö. (2013) · DergiPark (Istanbul University) · doi:10.16988/iuvfd.24024 · Cited by 1
The Genetic Characterization of DGAT1 Gene in Donkey Populations Reared in Thrace Region of Turkey
Özdïl, F. (2020) · Tarım Bilimleri Dergisi · doi:10.15832/ankutbd.451099 · Cited by 1
Innovations in the dairy chain: bio-economic analysis of novel breeding opportunities
Demeter, R. M. (2011) · doi:10.18174/188948 · Cited by 1
Genetisk variation av betydelse för mjölkkvalitet i Rödkullerasen
Umeland, P. (2006) · Epsilon Archive for Student Projects (University of Southampton) · Cited by 1
Bal, O., & Akyüz, B. (2014) · DergiPark (Istanbul University)
Candidate genes for beef quality
Leveau, C. (2008)
Genetisk variation i mjölkens sammansättning, art- resp. rasvariation
Ragnmark, V. (2010) · Epsilon Archive for Student Projects (University of Southampton)
Statistical analyses of milk traits in the New Zealand dairy cattle population
Hayr, M. K. (2014) · Iowa State University Digital Repository (Iowa State University) · doi:10.31274/etd-180810-3564
SNPs rs471462296, rs456245081 and rs438495570 in the 5’UTR region of DGAT1 gene in Nelore
Freire, K. M. B., Silva, C. C., Duarte, S. S. M., Teodoro, L. D. S., Costa, E., Silva, D. C., Godoy, F. R., da Cruz, A. D., & da Cruz, A. S. (2019) · Arquivo Brasileiro de Medicina Veterinária e Zootecnia · doi:10.1590/1678-4162-10157
The Genetic Characterization of DGAT1 Gene in Donkey Populations Reared in Thrace Region of Turkey
Özdïl, F. (2018) · Tarım Bilimleri Dergisi · doi:10.15832/ankutbd.499149
Genetic profiling of K232A mutation of DGAT1 gene in Murrah buffalo
Kaur, R., Magotra, A., Kumar, S., Gera, S., Karan, R., Kamaldeep, K., Garg, A. R., & Puspha (2024) · Buffalo Bulletin · doi:10.56825/bufbu.2024.4343561
Detection of the DGAT1 K232A Polymorphism in the South Anatolian Red (SAR) Cattle Breed in Türkiye
Yiğin, A., KILIÇ, Ş., Bozkaya, F., & Ekici, S. (2026) · Etlik Veteriner Mikrobiyoloji Dergisi · doi:10.35864/evmd.1767731
Factors associated with spontaneous oxidized flavour in cow’s milk
Juhlin, J. (2010) · Epsilon Open Archive (Sveriges lantbruksuniversitet biblioteket (Swedish University of Agricultural Sciences))
Metadata
- Authors
- Kaupe, B., Winter, A., Fries, R., & Erhardt, G.
- Affiliations
- Justus-Liebig-Universität Gießen (DE)
- Technical University of Munich (DE)
- Venue
- Journal of Dairy Research
- Publisher
- Cambridge University Press (CUP)
- Published
- 2004-05
- Volume
- 71
- Issue
- 2
- Pages
- 182-187
- ISSN
- 0022-0299 (ISSN-L)
- 1469-7629
- OpenAlex
- W2019561793
- Cited by
- 124
- References
- 26
- Citations by year
- 2026: 2 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 5 · 2016: 2 · 2015: 10 · 2014: 10 · 2013: 9 · 2012: 8
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Dairy Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Milk Quality and Mastitis in Dairy Cows
- Keywords
- DGAT1, acyl-CoA:diacylglycerol acyltransferase, K232A polymorphism, Bos indicus, cattle, cattle breeds, milk fat content, milk yield, BTA14, quantitative trait loci, allele frequency, FST, N'Dama cattle, beef cattle, dairy cattle, dual-purpose cattle
- MeSH terms
- Acyltransferases, Alleles, Animals, Breeding, Cattle, Gene Frequency, Polymorphism, Genetic, Polymorphism, Restriction Fragment Length, Species Specificity, Genetic Variation, Polymerase Chain Reaction, Diacylglycerol O-Acyltransferase
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
