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The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice
Open accessAbstract
Summary: The pathogenicity for mice of two mutants of herpes simplex virus (type 1 and type 2), which fail to induce thymidine kinase, were compared with their respective parent strains. The mutants were much less virulent than the parents following either intracerebral or peripheral inoculation. The replication of the virus at the site of inoculation and its progression into the nervous system were studied. Following a very large inoculum in the ear, the type 1 mutant was found to establish a latent infection in the cervical dorsal root ganglia. Mice inoculated intracerebrally with small doses of the mutant viruses were solidly immune to challenge with lethal doses of the parent strain.
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Citations
Cited by
Experimental Therapy of Human Glioma by Means of a Genetically Engineered Virus Mutant
Martuza, R. L., Malick, A., Markert, J. M., Ruffner, K. L., & Coen, D. M. (1991) · Science · doi:10.1126/science.1851332 · Cited by 1,050
Herpes simplex virus‐based vectors
Lachmann, R. (2004) · International Journal of Experimental Pathology · doi:10.1111/j.0959-9673.2004.00383.x · Cited by 76
Metadata
- Authors
- Field, H. J., & Wildy, P.
- Venue
- Journal of Hygiene
- Publisher
- Cambridge University Press (CUP)
- Published
- 1978-10
- Volume
- 81
- Issue
- 2
- Pages
- 267-277
- ISSN
- 0022-1724 (ISSN-L)
- OpenAlex
- W2140938030
- Cited by
- 334
- References
- 0
- FWCI
- 9.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice. https://app.cochat.ai/papers/10.1017/s0022172400025109
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- Field, H. J., & Wildy, P. (1978). The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice. Journal of Hygiene. https://doi.org/10.1017/s0022172400025109
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
