Herpes simplex virus‐based vectors

Lachmann, Robin

doi:10.1111/j.0959-9673.2004.00383.x

Cited by 76Virus-based gene therapy researchHerpesvirus Infections and TreatmentsRNA Interference and Gene Delivery

Herpes simplex virus‐based vectors

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Lachmann, Robin·2004·International Journal of Experimental Pathology

DOI 10.1111/j.0959-9673.2004.00383.xPMC PMC2517519

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Abstract

Summary: Herpes simplex virus (HSV)‐based vectors have primarily been developed for neuronal gene delivery, taking advantage of the virus' natural neurotropism. Two types of vector are available: replication defective viruses, whose cytotoxicity has been abolished by deleting viral gene products, and amplicon vectors, which are plasmids packaged into HSV particles with the aid of a helper virus. In this review I discuss how the cytotoxicity of the wild‐type virus has been abolished, the progress which has been made toward defining promoter elements capable of directing long‐term transgene expression form the latent viral genome and some of the potential clinical uses of these versatile vectors.

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HSV vectors exhibit several advantages for prophylaxis against viral infections.
“In particular, HSV vectors exhibit several advantages for prophylaxis against viral infections.”
From Viral Vector Systems for Gene Therapy: A Comprehensive Literature Review of Progress and Biosafety Challenges (2020) · cites this paper as [115]
HSV vectors have also found applications in the CNS.
“HSV vectors have also found applications in the CNS.”
From Viral Vector Systems for Gene Therapy: A Comprehensive Literature Review of Progress and Biosafety Challenges (2020) · cites this paper as [115]

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Authors: Lachmann, R.
Affiliations: University of Cambridge (GB)
Corresponding author: Lachmann, Robin
ORCID: Lachmann, Robin
Venue: International Journal of Experimental Pathology
Publisher: Wiley
Published: 2004-08
Volume: 85
Issue: 4
Pages: 177-190
ISSN: 0959-9673 (ISSN-L)
1365-2613
DOI: 10.1111/j.0959-9673.2004.00383.x
PMC: PMC2517519
OpenAlex: W1932617137
Cited by: 76
References: 133
Citations by year: 2026: 5 · 2025: 5 · 2024: 7 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 7 · 2019: 6 · 2018: 3 · 2017: 4 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 2
FWCI: 0.30
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 11 d)
Locations: International Journal of Experimental Pathology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Keywords: herpes simplex virus vectors, neurotropism, amplicon vectors, helper virus, viral gene deletion, latent viral genome, transgene expression, promoter elements, gene therapy
MeSH terms: Genetic Vectors, Humans, Nervous System Diseases, Plasmids, Genetic Therapy, Gene Transfer Techniques, Simplexvirus, Gene Targeting

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