The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Experimental Therapy of Human Glioma by Means of a Genetically Engineered Virus Mutant
Abstract
Malignant gliomas are the most common malignant brain tumors and are almost always fatal. A thymidine kinase-negative mutant of herpes simplex virus-1 ( dl sptk) that is attenuated for neurovirulence was tested as a possible treatment for gliomas. In cell culture, dl sptk killed two long-term human glioma lines and three short-term human glioma cell populations. In nude mice with implanted subcutaneous and subrenal U87 human gliomas, intraneoplastic inoculation of dl sptk caused growth inhibition. In nude mice with intracranial U87 gliomas, intraneoplastic inoculation of dl sptk prolonged survival. Genetically engineered viruses such as dl sptk merit further evaluation as novel antineoplastic agents.
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Cites
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Assumptions in the radiotherapy of glioblastoma
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National survey of patterns of care for brain-tumor patients
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Infections with Herpes Simplex Viruses
Corey, L., & Spear, P. G. (1986) · New England Journal of Medicine · doi:10.1056/nejm198603203141205 · Cited by 379
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Self-citationThe pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice
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Induction of Both Thymidine and Deoxycytidine Kinase Activity by Herpes Viruses
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Progress and problems with the use of viral vectors for gene therapy
Thomas, C. E., Ehrhardt, A., & Kay, M. A. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1066 · Cited by 2,501
Oncolytic viruses: a new class of immunotherapy drugs
Kaufman, H. L., Kohlhapp, F. J., & Zloza, A. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4663 · Cited by 1,642
Russell, S. J., Peng, K.-W., & Bell, J. C. (2012) · Nature Biotechnology · doi:10.1038/nbt.2287 · Cited by 1,428
Oncolytic virus therapy: A new era of cancer treatment at dawn
Fukuhara, H., Ino, Y., & Todo, T. (2016) · Cancer Science · doi:10.1111/cas.13027 · Cited by 774
Markert, J. M., Liechty, P. G., Wang, W., Gaston, S., Braz, E., Karrasch, M., Nabors, L. B., Markiewicz, M., Lakeman, A. D., Palmer, C. A., et al. (2009) · Molecular Therapy · doi:10.1038/mt.2008.228 · Cited by 401
Self-citation
Metadata
- Authors
- Martuza, R. L., Malick, A., Markert, J. M., Ruffner, K. L., & Coen, D. M.
- Venue
- Science
- Published
- 1991-05-10
- Volume
- 252
- Issue
- 5007
- Pages
- 854-856
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2073134590
- Cited by
- 1,050
- References
- 15
- FWCI
- 8.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Martuza, R. L., Malick, A., Markert, J. M., Ruffner, K. L., & Coen, D. M. (1991). Experimental Therapy of Human Glioma by Means of a Genetically Engineered Virus Mutant. Science. https://doi.org/10.1126/science.1851332
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
