Diet and faecal flora in three dietary groups in rural northern Nigeria
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SUMMARY: Quantitative bacterial counts, concentrations of bile acids and bacterial enzyme profiles were measured in faecal samples from three tribal groups with distinctive dietary patterns in a rural area of northern Nigeria. Samples were obtained from Maguzawa (with a predominantly cereal diet), Hausa (cereal with regular meat consumption) and Fulani (cereal with frequent consumption of cows' milk). Numbers of bacteroides, clostridia and concentrations of bile acids were lower in the Maguzawa than the other dietary groups but these differences were not statistically significant. Bacterial enzyme profiles in each group were similar. The results are discussed with respect to possible influences of diet on the human intestinal microflora.
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Drug toxicities and efficacies vary greatly between individual patients due to genetic and environmental influences such as nutrients, drug intake, and gut microbiome.
“In addition, drug toxicities and efficacies greatly vary depending on the individual patient, given both genetic81 and environmental influences (eg, nutrients,82, 83 drug intake,83, 84 gut microbiome85, 86).”
From Microfluidic Organ-on-a-Chip Models of Human Intestine (2018) · cites this paper as [82]
The Discussion (page unavailable) says a faecal bacterial enzyme, β-glucuronidase, has an important role in drug metabolism. That supports a connection between gut flora and drugs, but the paper does not establish that gut microbiome differences cause large patient-to-patient variation in drug toxicity or efficacy; its Results found similar bacterial-enzyme profiles across the dietary groups. (LLM, conf=0.85)
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Human gut microbiota: Does diet matter?
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- Authors
- Drasar, B. S., Montgomery, F., & Tomkins, A. M.
- Affiliations
- London School of Hygiene & Tropical Medicine (GB)
- ORCID
- Tomkins, A. M.
- Venue
- Journal of Hygiene
- Publisher
- Cambridge University Press (CUP)
- Published
- 1986-02
- Volume
- 96
- Issue
- 1
- Pages
- 59-65
- ISSN
- 0022-1724 (ISSN-L)
- PMC
- PMC2129582
- OpenAlex
- W2172300346
- Cited by
- 14
- References
- 0
- Citations by year
- 2023: 1 · 2022: 1 · 2018: 1 · 2017: 1 · 2014: 1 · 2013: 1
- FWCI
- 0.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Hygiene (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Digestive system and related health
- Keywords
- diet, fecal microbiota, gut microbiota, bile acids, Bacteroides, Clostridia, cereal-based diets, meat consumption, cow's milk consumption, Hausa language, Fulani, tribal population, Northern Nigeria
- MeSH terms
- Adult, Bacteria, Anaerobic, Bacteroides, Bifidobacterium, Bile Acids and Salts, Child, Clostridium, Culture Media, Diet, Enterobacteriaceae, Ethnicity, Feces, Humans, Hydrolases, Infant, Nigeria, Rural Population
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