The DOI matches its Crossref record; 145 of the 145 references it cites were found in a registry or an index.
Vitamin D and immune function: an overview
Open accessAbstract
Immunomodulatory actions of vitamin D have been recognised for over a quarter of a century, but it is only in the last few years that the significance of this to normal human physiology has become apparent. Two key factors have underpinned this revised perspective. Firstly, there are increasing data linking vitamin insufficiency with prevalent immune disorders. Improved awareness of low circulating levels of precursor 25-hydroxyvitamin D in populations across the globe has prompted epidemiological investigations of health problems associated with vitamin D insufficiency. Prominent among these are autoimmune diseases such as multiple sclerosis, type 1 diabetes and Crohn's disease, but more recent studies indicate that infections such as tuberculosis may also be linked to low 25-hydroxyvitamin D levels. The second factor expanding the link between vitamin D and the immune system is our improved knowledge of the mechanisms that facilitate this association. It is now clear that cells from the immune system contain all the machinery needed to convert 25-hydroxyvitamin D to active 1,25-dihydroxyvitamin D, and for subsequent responses to 1,25-dihydroxyvitamin D. Mechanisms such as this are important for promoting antimicrobial responses to pathogens in macrophages, and for regulating the maturation of antigen-presenting dendritic cells. The latter may be a key pathway by which vitamin D controls T-lymphocyte (T-cell) function. However, T-cells also exhibit direct responses to 1,25-dihydroxyvitamin D, notably the development of suppressor regulatory T-cells. Collectively these observations suggest that vitamin D is a key factor linking innate and adaptive immunity, and both of these functions may be compromised under conditions of vitamin D insufficiency.
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Cites
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Self-citationAutophagy as a Regulated Pathway of Cellular Degradation
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Cited by
Nutrition, immunity and COVID-19
Calder, P. C. (2020) · BMJ Nutrition, Prevention & Health · doi:10.1136/bmjnph-2020-000085 · Cited by 426
Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS)
Dancer, R. C. A., Parekh, D., Lax, S., D'Souza, V., Zheng, S., Bassford, C. R., Park, D., Bartis, D. G., Mahida, R., Turner, A. M., et al. (2015) · Thorax · doi:10.1136/thoraxjnl-2014-206680 · Cited by 316
Calder, P. C. (2013) · Proceedings of The Nutrition Society · doi:10.1017/s0029665113001286 · Cited by 283
Lucas, R. M., Norval, M., Neale, R. E., Young, A. R., de Gruijl, F. R., Takizawa, Y., & van der Leun, J. C. (2014) · Photochemical & Photobiological Sciences · doi:10.1039/c4pp90033b · Cited by 158
The Role of Nutrition in COVID-19 Susceptibility and Severity of Disease: A Systematic Review
James, P. T., Ali, Z., Armitage, A. E., Bonell, A., Cerami, C., Drakesmith, H., Jobe, M., Jones, K. S., Liew, Z., Moore, S. E., et al. (2021) · The Journal of Nutrition · doi:10.1093/jn/nxab059 · Cited by 147
Metadata
- Authors
- Hewison, M.
- Venue
- Proceedings of the Nutrition Society
- Publisher
- Cambridge University Press (CUP)
- Published
- 2011-08-18
- Volume
- 71
- Issue
- 1
- Pages
- 50-61
- ISSN
- 0029-6651 (ISSN-L)
- 1475-2719
- OpenAlex
- W2104754533
- Cited by
- 419
- References
- 145
- FWCI
- 13.60
- Type
- journal article
- Language
- en
- Open access
- bronze
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