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Cited by 457Neural and Behavioral Psychology StudiesDementia and Cognitive Impairment ResearchHistorical and Modern Theater Studies

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Cognitive performance in tests sensitive to frontal lobe dysfunction in the elderly depressed

Beats, B. C., Sahakian, B. J., Levy, R.·1996·Psychological Medicine
DOI 10.1017/s0033291700035662
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Abstract

The paper reports the profile of impairment across a variety of cognitive functions with special emphasis on tests sensitive to frontal lobe dysfunction, in 24 elderly depressed patients during and on recovery from mood disorder, compared with 15 age- and sex-matched controls. Traditional neuropsychological tests and a recently developed battery of computerized tests (CANTAB) were used. Impairments were found in the depressed group compared to controls and to themselves on recovery across all domains examined. The depressed group showed deficits on visuospatial recognition memory, attentional shifting at the extra-dimensional shift stage and in measures of both processing and motor speed without impaired accuracy in a visual search task. Impairments were also found on a planning task with disproportionately increased numbers of moves needed for more difficult problems and evidence of both slowed motor response and increased processing time once the task was commenced. Performance on recovery improved across all tasks. Comparisons were made with the performance of patients suffering from dementia of the Alzheimer type (DAT) and Parkinson's disease on similar tests. Response latencies in test performance were found to correlate with the number of episodes of depression suffered and with ventricular size on CT scan, as measured by computerized planimetry. On recovery, residual depression scores correlated with latency of test performance and with ventricular brain ratio. The results, thus, show that depression in the elderly is associated with a significant degree of deficit on tests sensitive to frontostriatal dysfunction. Some of the deficits appear specific to depression and some do not remit following clinical recovery. However, these impairments have to be interpreted in the context of a broad profile of cognitive deficit.

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Crossref · 10.1017/s0033291700035662

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Citations

Cites

Show all 42 references

Research works printed but not linked: 5

  1. Milner, 1964, The Frontal Granular Cortex and Behaviour, 313
  2. 1987, Diagnostic and Statistical Manual of Mental Disorders
  3. Kendrick, 1985, Kendrick Cognitive Tests for the Elderly
  4. Wechsler, 1955, Wechsler Adult Intelligence Scale Manual
  5. Nelson, National Adult Reading Test Manual

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Metadata

Authors
Beats, B. C., Sahakian, B. J., & Levy, R.
Affiliations
University of Cambridge (GB)
Corresponding author
Sahakian, B. J.
ORCID
Sahakian, B. J.
Venue
Psychological Medicine
Publisher
Cambridge University Press (CUP)
Published
1996-05
Volume
26
Issue
3
Pages
591-603
ISSN
  • 0033-2917 (ISSN-L)
  • 1469-8978
DOI
10.1017/s0033291700035662
OpenAlex
W2099301748
Cited by
457
References
42
Citations by year
2026: 1 · 2025: 9 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 10 · 2019: 10 · 2018: 8 · 2017: 13 · 2016: 16 · 2015: 16 · 2014: 13 · 2013: 32 · 2012: 23
FWCI
7.35
Type
journal article
Language
en
Open access
closed
Licence
www.cambridge.org/core/terms (unspecified, 4817 d)
Locations
  • Psychological Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
Wellcome Trust
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
Keywords
geriatric depression, frontal lobe dysfunction, cognitive impairment, frontostriatal dysfunction, attentional shift, processing speed, motor speed, planning, response latency, ventriculomegaly, residual depression, recovery from depression, Alzheimer's disease, Parkinson's disease, CANTAB
MeSH terms
Aged, Alzheimer Disease, Attention, Brain Mapping, Cognition Disorders, Corpus Striatum, Dementia, Female, Follow-Up Studies, Frontal Lobe, Humans, Male, Middle Aged, Neural Pathways, Neuropsychological Tests, Problem Solving, Psychometrics, Psychomotor Performance, Mental Recall, Reference Values, Tomography, X-Ray Computed

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