The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Neuroticism as a risk factor for schizophrenia
Abstract
Background. Neuroticism has been shown to increase the risk of depression whereas extraversion is associated with a reduction of risk. These personality traits play a central role in aetiological theories of affective disorder but their role in schizophrenia is unclear. In this study, the risk for schizophrenia associated with neuroticism and extraversion was examined and quantified. Methods. Neuroticism and extraversion rated at the age of 16 years were examined in relation to adult schizophrenia in a national birth cohort of 5362 individuals. Results. Neuroticism increased the risk of later schizophrenia independent of the level of affective symptoms in adult life (odds ratio over three levels: 1·93, 95% CI 1·09–3·43), whereas extraversion reduced the risk (OR: 0·44, 95% CI 0·23–0·84). Conclusions. Depression and schizophrenia may share personality risk-increasing and risk-reducing factors. Coping styles associated with particular personality traits may determine whether isolated symptoms progress to full-blown illness.
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Citations
Cites
Personality Dimensions and Depression: Review and Commentary
Enns, M. W., & Cox, B. J. (1997) · The Canadian Journal of Psychiatry · doi:10.1177/070674379704200305 · Cited by 241 · cited 2×
“In line with previous research (Maier et al. 1992; Enns & Cox, 1997), earlier investigations in this cohort established that childhood neuroticism was a strong risk factor for adult non-psychotic affective disorder (Rodgers, 1990), whereas extraversion reduced the risk (Van Os & Jones, 1999).”
BackgroundResultLindelow, M., Hardy, R., & Rodgers, B. (1997) · Journal of Epidemiology and Community Health · doi:10.1136/jech.51.5.549 · Cited by 113
Cited by
Public health significance of neuroticism
Lahey, B. B. (2009) · American Psychologist · doi:10.1037/a0015309 · Cited by 1,901
Moving Forward: Challenges and Directions for Psychopathological Network Theory and Methodology
Fried, E. I., & Cramer, A. O. J. (2017) · Perspectives on Psychological Science · doi:10.1177/1745691617705892 · Cited by 938
23andMe Research Team, Nagel, M., Jansen, P. R., Stringer, S., Watanabe, K., de Leeuw, C. A., Bryois, J., Savage, J. E., Hammerschlag, A. R., Skene, N. G., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0151-7 · Cited by 799
Stress-reactivity in psychosis: Evidence for an affective pathway to psychosis
Myin-Germeys, I., & van Os, J. (2007) · Clinical Psychology Review · doi:10.1016/j.cpr.2006.09.005 · Cited by 719
Self-citationCramer, A. O. J., Van Der Sluis, S., Noordhof, A., Wichers, M., Geschwind, N., Aggen, S. H., Kendler, K. S., & Borsboom, D. (2012) · European Journal of Personality · doi:10.1002/per.1866 · Cited by 477
Metadata
- Authors
- VAN OS, J., & B. JONES, P.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2001-07-31
- Volume
- 31
- Issue
- 6
- Pages
- 1129-1134
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2061643986
- Cited by
- 285
- References
- 2
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
