Trends in cannabis use prior to first presentation with schizophrenia, in South-East London between 1965 and 1999
Abstract
Background There is evidence that cannabis use might be relevant to the aetiology of schizophrenia. We aimed to measure any change in cannabis use over time in those first presenting with schizophrenia in South-East London from 1965 to 1999, and compare this with change in use in those presenting with non-psychotic psychiatric disorders. Method The rate of cannabis use in the year prior to first ever presentation was measured over seven time periods. Logistic regression modelling was used to determine (a) whether cannabis use changed over time, after controlling for age, sex and ethnicity, and (b) whether there was an interaction between diagnosis and time. Results Cannabis use increased over time in both the schizophrenia group [odds ratio per time period (OR) 2.03, 95% confidence interval (CI) 1.74-2.38, p Conclusion Cannabis use in the year prior to presentation with schizophrenia increased markedly between 1965 and 1999, and disproportionately so compared to increase in cannabis use in other psychiatric disorders.
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Confounding by other drug use or by prior psychological deviancy does not negate the effect of cannabis.
“Confounding by other drug use or by prior psychological deviancy does not negate the effect of cannabis.”
From Will Legalization and Commercialization of Cannabis Use Increase the Incidence and Prevalence of Psychosis? (2020) · cites this paper as [6]
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- Authors
- BOYDELL, J., VAN OS, J., CASPI, A., KENNEDY, N., GIOUROUKOU, E., FEARON, P., FARRELL, M., & MURRAY, R. M.
- Affiliations
- King's College London (GB)
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2006-07-20
- Volume
- 36
- Issue
- 10
- Pages
- 1441-1446
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2112281229
- Cited by
- 70
- References
- 0
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2020: 10 · 2019: 4 · 2018: 1 · 2017: 4 · 2016: 4 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 4
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Stanley Medical Research Institute
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- cannabis use, schizophrenia, temporal trends, etiology of schizophrenia, South East London
- MeSH terms
- Adult, Marijuana Abuse, Catchment Area, Health, England, Female, Humans, Male, Schizophrenia, Comorbidity, Incidence, Prevalence, Age of Onset
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