Cannabis and adolescent brain development.

Lubman, Dan I.; Cheetham, Ali; Yücel, Murat

doi:10.1016/j.pharmthera.2014.11.009

Cited by 360Cannabis and Cannabinoid ResearchPrenatal Substance Exposure EffectsSubstance Abuse Treatment and Outcomes

Cannabis and adolescent brain development.

Lubman, Dan I., Cheetham, Ali, Yücel, Murat·2015·Pharmacology & Therapeutics

DOI 10.1016/j.pharmthera.2014.11.009

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Abstract

Heavy cannabis use has been frequently associated with increased rates of mental illness and cognitive impairment, particularly amongst adolescent users. However, the neurobiological processes that underlie these associations are still not well understood. In this review, we discuss the findings of studies examining the acute and chronic effects of cannabis use on the brain, with a particular focus on the impact of commencing use during adolescence. Accumulating evidence from both animal and human studies suggests that regular heavy use during this period is associated with more severe and persistent negative outcomes than use during adulthood, suggesting that the adolescent brain may be particularly vulnerable to the effects of cannabis exposure. As the endocannabinoid system plays an important role in brain development, it is plausible that prolonged use during adolescence results in a disruption in the normative neuromaturational processes that occur during this period. We identify synaptic pruning and white matter development as two processes that may be adversely impacted by cannabis exposure during adolescence. Potentially, alterations in these processes may underlie the cognitive and emotional deficits that have been associated with regular use commencing during adolescence.

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Other longitudinal studies argue against the strength or persistence of deficits over shorter periods, especially in studies where abstinence was carefully monitored.
“Further, other longitudinal studies argue against the strength or persistence of deficits over shorter periods, 17,20 especially in studies where abstinence was carefully monitored.101”
From Association of Cannabis With Cognitive Functioning in Adolescents and Young Adults: A Systematic Review and Meta-analysis (2018) · cites this paper as [20]

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Altered brain tissue composition in heavy marijuana users
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Effects of Cannabinoids on Neurotransmission
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An introduction to the endocannabinoid system: from the early to the latest concepts
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Gene-Environment Interplay Between Cannabis and Psychosis
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Critical Review
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Control of the cell survival/death decision by cannabinoids
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Brain glucose metabolism in chronic marijuana users at baseline and during marijuana intoxication
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Anxiolytic-like effect of cannabidiol in the rat Vogel conflict test
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Cannabidiol inhibits the hyperlocomotion induced by psychotomimetic drugs in mice
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White matter abnormalities in major depression: Evidence from post-mortem, neuroimaging and genetic studies
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Cannabis use and childhood trauma interact additively to increase the risk of psychotic symptoms in adolescence
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Neuroimaging in cannabis use: a systematic review of the literature
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Dendritic spine formation and pruning: common cellular mechanisms?
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Lasting Impacts of Prenatal Cannabis Exposure and the Role of Endogenous Cannabinoids In the Developing Brain
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PRECLINICAL STUDY: Acute and chronic cannabinoid treatment differentially affects recognition memory and social behavior in pubertal and adult rats
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“…users, including smaller whole brain and cortical grey matter volumes (Wilson et al., 2000), altered prefrontal and insular cortical thickness (Lopez-Larson et al., 2011), smaller right medial OFC volumes (Churchwell et al., 2010), smaller hippocampal volumes (Ashtari et al., 2011), greater…”
Endocannabinoid functions controlling neuronal specification during brain development
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Cannabis Use and Dependence: Public Health and Public Policy
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Cellular and Molecular Mechanisms Underlying Learning and Memory Impairments Produced by Cannabinoids: Figure 1.Preprint
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CNR1 Gene is Associated with High Neuroticism and Low Agreeableness and Interacts with Recent Negative Life Events to Predict Current Depressive Symptoms
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IMAGING STUDY: Prefrontal cortex morphometry in abstinent adolescent marijuana users: subtle gender effects
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Effects of Cannabis Use on Human Behavior, Including Cognition, Motivation, and Psychosis: A Review
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Adolescent E-Cigarette, Hookah, and Conventional Cigarette Use and Subsequent Marijuana Use
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Comparative Pharmacokinetics of Δ9-Tetrahydrocannabinol in Adolescent and Adult Male Mice
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Rapid increase in the prevalence of cannabis use among people with depression in the United States, 2005–17: the role of differentially changing risk perceptions
Pacek, L. R., Weinberger, A. H., Zhu, J., & Goodwin, R. D. (2019) · Addiction · doi:10.1111/add.14883 · Cited by 90 · see citing works
Trends and Correlates of Cannabis-involved Emergency Department Visits: 2004 to 2011
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Endocannabinoids in brain plasticity: Cortical maturation, HPA axis function and behavior
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An epidemiological, developmental and clinical overview of cannabis use during pregnancy
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A review investigating the relationship between cannabis use and adolescent cognitive functioning
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Cannabis smoking increases the risk of suicide ideation and suicide attempt in young individuals of 11–21 years: A systematic review and meta-analysis
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Longitudinal changes in cognition in young adult cannabis users
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Authors: Lubman, D. I., Cheetham, A., & Yücel, M.
Affiliations: Eastern Health (AU)
The University of Melbourne (AU)
Corresponding author: Lubman, Dan I.
ORCID: Lubman, Dan I.
Cheetham, Ali
Yücel, Murat
Venue: Pharmacology & Therapeutics
Publisher: Elsevier BV
Published: 2015-04
Volume: 148
Pages: 1-16
ISSN: 0163-7258 (ISSN-L)
DOI: 10.1016/j.pharmthera.2014.11.009
OpenAlex: W1985057601
Cited by: 360
References: 306
Citations by year: 2026: 11 · 2025: 33 · 2024: 28 · 2023: 33 · 2022: 46 · 2021: 29 · 2020: 42 · 2019: 37 · 2018: 36 · 2017: 26 · 2016: 27 · 2015: 11
FWCI: 2.72
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacology & Therapeutics (publishedVersion)
PubMed (publishedVersion)
Funders: NHMRC (1021973)
Topics: Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: cannabis use, adolescent brain development, endocannabinoid system, synaptic pruning, white matter development, neuromaturation, cognitive impairment, mental illness, neurodevelopmental vulnerability
MeSH terms: Adolescent, Animals, Brain, Cannabinoids, Cannabis, Depression, Female, Humans, Learning Disabilities, Memory Disorders, Pregnancy, Prenatal Exposure Delayed Effects, Schizophrenia, Endocannabinoids

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