Adolescent cannabis use and psychosis: epidemiology and neurodevelopmental models
Open accessAbstract
Cannabis is one of the most widely used illicit drugs among adolescents, and most users first experiment with it in adolescence. Adolescence is a critical phase for brain development, characterized by neuronal maturation and rearrangement processes, such as myelination, synaptic pruning and dendritic plasticity. The endocannabinoid system plays an important role in fundamental brain developmental processes such as neuronal cell proliferation, migration and differentiation. Therefore changes in endocannabinoid activity during this specific developmental phase, induced by the psychoactive component of marijuana, Δ 9‐tetrahydrocannabinol, might lead to subtle but lasting neurobiological changes that can affect brain functions and behaviour. In this review, we outline recent research into the endocannabinoid system focusing on the relationships between adolescent exposure to cannabinoids and increased risk for certain neuropsychiatric diseases such as schizophrenia, as highlighted by both human and animal studies. Particular emphasis will be given to the possible mechanisms by which adolescent cannabis consumption could render a person more susceptible to developing psychoses such as schizophrenia. This article is part of a themed issue on Cannabinoids. To view the editorial for this themed issue visit http://dx.doi.org/10.1111/j.1476‐5381.2010.00831.x
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One of the most concerning potential consequences of adolescent cannabis exposure is its propensity to precipitate first episode psychosis and the development of schizophrenia.
“One of the most concerning potential consequences of ACE is its propensity to precipitate first episode psychosis and the development of schizophrenia [112].”
From Consequences of adolescent drug use (2023) · cites this paper as [112]
In “Adolescent cannabis use and schizophrenia” (p. 514), the review says adolescent cannabis use appears causally linked to the development of psychoses such as schizophrenia. It also discusses adolescents presenting with first-episode psychosis, but that study compares symptoms in cannabis users and non-users; it does not establish that cannabis precipitated their first episode. (LLM, conf=0.82)
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- [9]9. Baeza I, Graell M, Moreno D, Castro-Fornieles J, Parellada M, Adolescent cannabis use and psychosis 518 DT Malone et al British Journal of Pharmacology (2010) 160 511-522
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- Authors
- Malone, D. T., Hill, M. N., & Rubino, T.
- Affiliations
- Monash University (AU)
- Rockefeller University (US)
- University of Insubria (IT)
- Corresponding author
- Rubino, Tiziana
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2010-05-19
- Volume
- 160
- Issue
- 3
- Pages
- 511-522
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- PMC
- PMC2931552
- OpenAlex
- W1542661692
- Cited by
- 237
- References
- 170
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 4 · 2023: 13 · 2022: 18 · 2021: 10 · 2020: 16 · 2019: 6 · 2018: 14 · 2017: 20 · 2016: 16 · 2015: 13 · 2014: 30 · 2013: 18 · 2012: 28
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Pharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- IrInSubria (University of Insubria) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Keywords
- adolescent cannabis use, psychosis, schizophrenia risk, endocannabinoid system, delta-9-tetrahydrocannabinol, brain development, synaptic pruning, myelination, dendritic plasticity, neuropsychiatric disorders, animal models
- MeSH terms
- Adolescent, Adolescent Behavior, Animals, Brain, Cannabinoids, Marijuana Abuse, Disease Models, Animal, Humans, Psychoses, Substance-Induced, Schizophrenia, Signal Transduction, Cannabinoid Receptor Modulators
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