The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Meta-analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives
Abstract
Background: Previous work suggests that impairments in executive function and verbal memory in particular may persist in euthymic bipolar patients and serve as an indicator of genetic risk (endophenotype). Method: A systematic review of the literature was undertaken. Effects sizes were extracted from selected papers and pooled using meta-analytical techniques. Results: In bipolar patients, large effect sizes ( d >0.8) were noted for executive functions (working memory, executive control, fluency) and verbal memory. Medium effect sizes (0.5< d <0.8) were reported for aspects of executive function (concept shifting, executive control), mental speed, visual memory, and sustained attention. Small effect sizes ( d <0.5) were found for visuoperception. In first-degree relatives, effect sizes were small ( d <0.5), but significantly different from healthy controls for executive function and verbal memory in particular. Conclusions: Executive function and verbal memory are candidate bipolar endophenotypes given large deficits in these domains in bipolar patients and small, but intermediate, cognitive impairments in first-degree relatives.
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Cites
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The functional neuroanatomy of bipolar disorder: a review of neuroimaging findings
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Sustained attention deficit in bipolar disorder
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Genes for Schizophrenia and Bipolar Disorder? Implications for Psychiatric Nosology
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Toward constructing an endophenotype strategy for bipolar disorders
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A Preliminary fMRI Study of Sustained Attention in Euthymic, Unmedicated Bipolar Disorder
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Cited by
van Os, J., & Kapur, S. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60995-8 · Cited by 1,971
Self-citationGoodwin, G., Haddad, P., Ferrier, I., Aronson, J., Barnes, T., Cipriani, A., Coghill, D., Fazel, S., Geddes, Jr., Grunze, H., et al. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116636545 · Cited by 1,309
Snyder, H. R., Miyake, A., & Hankin, B. L. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.00328 · Cited by 946
Kurtz, M. M., & Gerraty, R. T. (2009) · Neuropsychology · doi:10.1037/a0016277 · Cited by 433
The genetics of bipolar disorder
Barnett, J. H., & Smoller, J. W. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.03.080 · Cited by 407
Metadata
- Authors
- Arts, B., Jabben, N., Krabbendam, L., & van Os, J.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2007-10-09
- Volume
- 38
- Issue
- 6
- Pages
- 771-785
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2077455126
- Cited by
- 707
- References
- 13
- FWCI
- 17.47
- Type
- journal article
- Language
- en
- Open access
- closed
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