The functional neuroanatomy of bipolar disorder: a review of neuroimaging findings

Strakowski, S M; DelBello, M P; Adler, C M

doi:10.1038/sj.mp.4001585

Cited by 818Bipolar Disorder and TreatmentSchizophrenia research and treatmentNeural and Behavioral Psychology Studies

The functional neuroanatomy of bipolar disorder: a review of neuroimaging findings

Strakowski, S M, DelBello, M P, Adler, C M·2005·Molecular Psychiatry

DOI 10.1038/sj.mp.4001585

Open this paper in CoChat — free account

Abstract

The authors review existing structural and functional neuroimaging studies of patients with bipolar disorder and discuss how these investigations enhance our understanding of the neurophysiology of this illness. Findings from structural magnetic resonance imaging (MRI) studies suggest that some abnormalities, such as those in prefrontal cortical areas (SGPFC), striatum and amygdala exist early in the course of illness and, therefore, potentially, predate illness onset. In contrast, other abnormalities, such as those found in the cerebellar vermis, lateral ventricles and other prefrontal regions (eg, left inferior), appear to develop with repeated affective episodes, and may represent the effects of illness progression and associated factors. Magnetic resonance spectroscopy investigations have revealed abnormalities of membrane and second messenger metabolism, as well as bioenergetics, in striatum and prefrontal cortex. Functional imaging studies report activation differences between bipolar and healthy controls in these same anterior limibic regions. Together, these studies support a model of bipolar disorder that involves dysfunction within subcortical (striatal-thalamic)-prefrontal networks and the associated limbic modulating regions (amygdala, midline cerebellum). These studies suggest that, in bipolar disorder, there may be diminished prefrontal modulation of subcortical and medial temporal structures within the anterior limbic network (eg, amygdala, anterior striatum and thalamus) that results in dysregulation of mood. Future prospective and longitudinal studies focusing on these specific relationships are necessary to clarify the functional neuroanatomy of bipolar disorder.

Integrity signals

Registry

Crossref · 10.1038/sj.mp.4001585

Cites

87 of 87 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Evidence for abnormalities in reward-related neural network function in mania is scarce.
“Although functional MRI studies have identified prefrontal dysfunction in bipolar disorder and manic psychosis, evidence for abnormalities in reward-related neural network function in mania is scarce [271-275].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [274]

The cerebellar cognitive affective syndrome
Schmahmann, J. (1998) · Brain · doi:10.1093/brain/121.4.561 · Cited by 3,230 · see citing works
Subgenual prefrontal cortex abnormalities in mood disorders
Drevets, W. C., Price, J. L., Simpson, J. R., Todd, R. D., Reich, T., Vannier, M., & Raichle, M. E. (1997) · Nature · doi:10.1038/386824a0 · Cited by 2,693 · see citing works
Reciprocal Limbic-Cortical Function and Negative Mood: Converging PET Findings in Depression and Normal Sadness
Mayberg, H. S., Liotti, M., Brannan, S. K., McGinnis, S., Mahurin, R. K., Jerabek, P. A., Silva, J. A., Tekell, J. L., Martin, C. C., Lancaster, J. L., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.5.675 · Cited by 2,416 · see citing works
Frontal-subcortical circuits and human behavior
Cummings, J. L. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540080076020 · Cited by 2,262 · see citing works
Glial reduction in the subgenual prefrontal cortex in mood disorders
Öngür, D., Drevets, W. C., & Price, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13290 · Cited by 1,525 · see citing works
Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression∗∗See accompanying Editorial, in this issue.
Rajkowska, G., Miguel-Hidalgo, J. J., Wei, J., Dilley, G., Pittman, S. D., Meltzer, H. Y., Overholser, J. C., Roth, B. L., & Stockmeier, C. A. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00041-4 · Cited by 1,477 · see citing works
The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain.
Hallcher, L. M., & Sherman, W. R. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70391-3 · Cited by 1,102 · see citing works
Revised Prevalence Estimates of Mental Disorders in the United States
Narrow, W. E., Rae, D. S., Robins, L. N., & Regier, D. A. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.2.115 · Cited by 807 · see citing works
The anatomy of mood disorders—review of structural neuroimaging studies
Soares, J. C., & Mann, J. J. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00006-6 · Cited by 760 · see citing works
The emerging epidemiology of hypomania and bipolar II disorder
Angst, J. (1998) · Journal of Affective Disorders · doi:10.1016/s0165-0327(98)00142-6 · Cited by 758 · see citing works
MRI anatomy of schizophrenia
McCarley, R. W., Wible, C. G., Frumin, M., Hirayasu, Y., Levitt, J. J., Fischer, I. A., & Shenton, M. E. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00018-9 · Cited by 722 · see citing works
Amphetamine-induced dopamine release in human ventral striatum correlates with euphoria
Drevets, W. C., Gautier, C., Price, J. C., Kupfer, D. J., Kinahan, P. E., Grace, A. A., Price, J. L., & Mathis, C. A. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01038-6 · Cited by 706 · see citing works
Brain Magnetic Resonance Imaging of Structural Abnormalities in Bipolar Disorder
Strakowski, S. M., DelBello, M. P., Sax, K. W., Zimmerman, M. E., Shear, P. K., Hawkins, J. M., & Larson, E. R. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.3.254 · Cited by 619 · see citing works
Self-citation
Cerebral Metabolic Rates for Glucose in Mood Disorders
Baxter, L. R. (1985) · Archives of General Psychiatry · doi:10.1001/archpsyc.1985.01790280019002 · Cited by 602 · see citing works
Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder
Rajkowska, G., Halaris, A. E., & Selemon, L. D. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01080-0 · Cited by 572 · see citing works
A Functional Magnetic Resonance Imaging Study of Bipolar Disorder
Blumberg, H. P., Leung, H., Skudlarski, P., Lacadie, C., Fredericks, C. A., Harris, B. C., Charney, D. S., Gore, J. C., Krystal, J. H., & Peterson, B. S. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.6.601 · Cited by 475 · see citing works
Brain Metabolic Alterations in Medication-Free Patients With BipolarDisorder
Dager, S. R., Friedman, S. D., Parow, A. M., Demopulos, C. M., Stoll, A. L., Lyoo, I. K., Dünner, D. L., & Renshaw, P. F. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.5.450 · Cited by 453 · see citing works
N -Acetylaspartate in neuropsychiatric disorders
Tsai, G. E., & Coyle, J. T. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(95)00014-m · Cited by 422 · see citing works
Subcortical and temporal structures in affective disorder and schizophrenia: A magnetic resonance imaging study
Swayze, V. W., Andreasen, N. C., Alliger, R. J., Yuh, W. T. C., & Ehrhardt, J. C. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90046-3 · Cited by 403 · see citing works
Lithium increases N-acetyl-aspartate in the human brain: in vivo evidence in support of bcl-2’s neurotrophic effects?
Moore, G. J., Bebchuk, J. M., Hasanat, K., Chen, G., Seraji‐Bozorgzad, N., Wilds, I. B., Faulk, M. W., Koch, S., Glitz, D. A., Jolkovsky, L., et al. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00252-3 · Cited by 401 · see citing works
An MRI study of temporal lobe structures in men with bipolar disorder or schizophrenia
Altshuler, L. L., Bartzokis, G., Grieder, T., Curran, J., Jimenez, T., Leight, K., Wilkins, J., Gerner, R., & Mintz, J. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00836-2 · Cited by 369 · see citing works
In vivo 1H MRS choline: Correlation with in vitro chemistry/histology
Miller, B. L., Changl, L., Booth, R. A., Ernst, T., Cornford, M. E., Nikas, D. L., McBride, D. Q., & Jenden, D. J. (1996) · Life Sciences · doi:10.1016/0024-3205(96)00182-8 · Cited by 368 · see citing works
Ventricular and Periventricular Structural Volumes in First- Versus Multiple-Episode Bipolar Disorder
Strakowski, S. M., DelBello, M. P., Zimmerman, M. E., Getz, G. E., Mills, N. P., Ret, J., Shear, P. K., & Adler, C. M. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.11.1841 · Cited by 363 · see citing works
Self-citation
fMRI during affect discrimination in bipolar affective disorder
Yurgelun‐Todd, D. A., Gruber, S. A., Kanayama, G., Killgore, W. D., Baird, A. A., & Young, A. D. (2000) · Bipolar Disorders · doi:10.1034/j.1399-5618.2000.20304.x · Cited by 359 · see citing works
Medial and superior temporal gyral volumes and cerebral asymmetry in schizophrenia versus bipolar disorder
Pearlson, G. D., Barta, P. E., Powers, R. E., Menon, R. R., Richards, S. S., Aylward, E., Federman, E. B., Chase, G. A., Petty, R. G., & Tien, A. Y. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00373-3 · Cited by 358 · see citing works
Magnetic resonance imaging analysis of amygdala and other subcortical brain regions in adolescents with bipolar disorder
DelBello, M. P., Zimmerman, M. E., Mills, N. P., Getz, G. E., & Strakowski, S. M. (2004) · Bipolar Disorders · doi:10.1046/j.1399-5618.2003.00087.x · Cited by 344 · see citing works
Self-citation
Neuroimaging in bipolar disorder
Strakowski, S. M., DelBello, M. P., Adler, C. M., Cecil, K. M., & Sax, K. W. (2000) · Bipolar Disorders · doi:10.1034/j.1399-5618.2000.020302.x · Cited by 322 · see citing works
Self-citation
Subgenual Cingulate Cortex Volume in First-Episode Psychosis
Hirayasu, Y., Shenton, M. E., Salisbury, D. F., Kwon, J. S., Wible, C. G., Fischer, I. A., Yurgelun-Todd, D., Zarate, C., Kikinis, R., Jolesz, F. A., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.7.1091 · Cited by 301 · see citing works
Decreased dorsolateral prefrontal N-acetyl aspartate in bipolar disorder
Winsberg, M. E., Sachs, N., Tate, D. L., Elfar Adalsteinsson, A., Spielman, D. M., & Ketter, T. A. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00183-3 · Cited by 294 · see citing works
Effects of mood and subtype on cerebral glucose metabolism in treatment-resistant bipolar disorder
Ketter, T. A., Kimbrell, T. A., George, M. S., Dunn, R. T., Speer, A. M., Benson, B. E., Willis, M. W., Danielson, A., Frye, M. A., Herscovitch, P., et al. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00975-6 · Cited by 291 · see citing works
Rostral and Orbital Prefrontal Cortex Dysfunction in the Manic State of Bipolar Disorder
Blumberg, H. P., Stern, E. R., Ricketts, S., Martínez, D., de Asis, J. M., White, T. G., Epstein, J., Isenberg, N., McBride, P., Kemperman, I., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.12.1986 · Cited by 290 · see citing works
Regional prefrontal gray and white matter abnormalities in bipolar disorder
Lopez-Larson, M. P., DelBello, M. P., Zimmerman, M. E., Schwiers, M., & Strakowski, S. M. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01350-1 · Cited by 279 · see citing works
Self-citation
Increased anterior cingulate and caudate activity in bipolar mania
Blumberg, H. P., Stern, E. R., Martínez, D., Ricketts, S., de Asis, J. M., White, T. G., Epstein, J., McBride, P., Eidelberg, D., Kocsis, J. H., et al. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00962-8 · Cited by 276 · see citing works
Basal ganglia volumes and white matter hyperintensities in patients with bipolar disorder
Aylward, E., Roberts-Twillie, J. V., Barta, P. E., Kumar, A. J., Harris, G. J., Geer, M. J., Peyser, C. E., & Pearlson, G. D. (1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.5.687 · Cited by 273 · see citing works
Decreased Anterior Cingulate Myo-inositol/Creatine Spectroscopy Resonance with Lithium Treatment in Children with Bipolar Disorder
Davanzo, P. A. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00207-4 · Cited by 251 · see citing works
A Preliminary fMRI Study of Sustained Attention in Euthymic, Unmedicated Bipolar Disorder
Strakowski, S. M., Adler, C. M., Holland, S. K., Mills, N., & DelBello, M. P. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300492 · Cited by 242 · see citing works
Self-citation
Decision-making in mania: a PET study
Rubinsztein, J. S. (2001) · Brain · doi:10.1093/brain/124.12.2550 · Cited by 238 · see citing works
Frontostriatal Abnormalities in Adolescents With Bipolar Disorder: Preliminary Observations From Functional MRI
Blumberg, H. P., Martin, A., Kaufman, J., Leung, H.-C., Skudlarski, P., Lacadie, C., Fulbright, R. K., Gore, J. C., Charney, D. S., Krystal, J. H., et al. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.7.1345 · Cited by 235 · see citing works
In Vivo D2 Dopamine Receptor Density in Psychotic and Nonpsychotic Patients With Bipolar Disorder
Pearlson, G. D. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950180057008 · Cited by 235 · see citing works
MRI Analysis of the Cerebellum in Bipolar Disorder A Pilot Study
DelBello, M. P. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00026-3 · Cited by 234 · see citing works
Self-citation
MRI investigation of temporal lobe structures in bipolar patients
Brambilla, P., Harenski, K. A., Nicoletti, M., Sassi, R. B., Mallinger, A. G., Frank, E., Kupfer, D. J., Keshavan, M. S., & Soares, J. C. (2003) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(03)00024-4 · Cited by 229 · see citing works
Frontosubcortical Neuroanatomy and the Continuous Performance Test in Mania
Sax, K. W., Strakowski, S. M., Zimmerman, M. E., DelBello, M. P., Keck, P. E., & Hawkins, J. M. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.1.139 · Cited by 229 · see citing works
Self-citation
T2 hyperintensities in bipolar disorder: magnetic resonance imaging comparison and literature meta-analysis
Ll, A., Curran, J. G., Hauser, P., Mintz, J., Denicoff, K. D., & Post, R. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.8.1139 · Cited by 229 · see citing works
Brain SPECT Imaging of Amphetamine-Induced Dopamine Release in Euthymic Bipolar Disorder Patients
Anand, A., Verhoeff, P., Seneca, N., Zoghbi, S. S., Seibyl, J. P., Charney, D. S., & Innis, R. B. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.7.1108 · Cited by 222 · see citing works
Manic-depressive and pure manic states after brain lesions
STARKSTEIN, S. E., Fedoroff, P., Berthier, M. L., & Robinson, R. G. (1991) · Biological Psychiatry · doi:10.1016/0006-3223(91)90043-l · Cited by 212 · see citing works
Abnormal frontal white matter tracts in bipolar disorder: a diffusion tensor imaging study
Adler, C. M., Holland, S. K., Schmithorst, V. J., Wilke, M., Weiss, K. L., Pan, H., & Strakowski, S. M. (2004) · Bipolar Disorders · doi:10.1111/j.1399-5618.2004.00108.x · Cited by 211 · see citing works
Self-citation
Frontal lobe differences in bipolar disorder as determined by proton MR spectroscopy
Cecil, K. M., DelBello, M. P., Morey, R., & Strakowski, S. M. (2002) · Bipolar Disorders · doi:10.1034/j.1399-5618.2002.02235.x · Cited by 207 · see citing works
Self-citation
Structural brain abnormalities in first-episode mania
Strakowski, S. M., Wilson, D. R., Tohen, M. F., Woods, B. T., Douglass, A. W., & Stoll, A. L. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90098-x · Cited by 204 · see citing works
Self-citation
Neuronal pathology in the hippocampal area of patients with bipolar disorder: a study with proton magnetic resonance spectroscopic imaging
Bertolino, A., Frye, M. A., Callicott, J. H., Mattay, V. S., Rakow‐Penner, R., Shelton, J. R., Post, R. M., & Weinberger, D. R. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01911-x · Cited by 201 · see citing works
Choline, myo‐inositol and mood in bipolar disorder: a proton magnetic resonance spectroscopic imaging study of the anterior cingulate cortex
Moore, C. M., Breeze, J. L., Gruber, S. A., Babb, S. M., Frederick, B. B., Villafuerte, R. A., Stoll, A. L., Hennen, J. A., Yurgelun-Todd, D. A., Cohen, B. M., et al. (2000) · Bipolar Disorders · doi:10.1034/j.1399-5618.2000.20302.x · Cited by 197 · see citing works
Temporal Dissociation Between Lithium-Induced Changes in Frontal Lobe myo-Inositol and Clinical Response in Manic-Depressive Illness
Moore, G. J., Bebchuk, J. M., Parrish, J. K., Faulk, M. W., Arfken, C. L., Strahl-Bevacqua, J., & Manji, H. K. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.12.1902 · Cited by 196 · see citing works
Volumetric MRI studies of mood disorders: do they distinguish unipolar and bipolar disorder?
Strakowski, S. M., Adler, C. M., & DelBello, M. P. (2002) · Bipolar Disorders · doi:10.1034/j.1399-5618.2002.01160.x · Cited by 188 · see citing works
Self-citation
Proton MR spectroscopy in children with bipolar affective disorder: preliminary observations.
Castillo, M., Kwock, L., Courvoisie, H. E., & Hooper, S. R. (2000) · PubMed Central · Cited by 177 · see citing works
Premenstrual Dysphonias: Myths and Realities
Altshuler, L. L. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.5.804 · Cited by 169 · see citing works
Anatomical MRI Study of Subgenual Prefrontal Cortex in Bipolar and Unipolar Subjects
Brambilla, P. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00352-4 · Cited by 164 · see citing works
D1 dopamine receptor binding in mood disorders measured by positron emission tomography
Suhara, T., Nakayama, K., Inoue, O., Fukuda, H., Shimizu, M., Mori, A., & Tateno, Y. (1992) · Psychopharmacology · doi:10.1007/bf02253582 · Cited by 163 · see citing works
A volumetric magnetic resonance imaging study of monozygotic twins discordant for bipolar disorder
Noga, J. T., Vladar, K., & Torrey, Ε. F. (2001) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(00)00084-6 · Cited by 163 · see citing works
Proton Magnetic Resonance Spectroscopy of the Frontal Lobe and Cerebellar Vermis in Children with a Mood Disorder and a Familial Risk for Bipolar Disorders
Cecil, K. M., DelBello, M. P., Sellars, M. C., & Strakowski, S. M. (2003) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/104454603322724931 · Cited by 162 · see citing works
Self-citation
Decreased N-Acetylaspartate in children with familial bipolar disorder
Chang, K., Adleman, N. E., Dienes, K., Barnea‐Goraly, N., Reiss, A. L., & Ketter, T. A. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01744-4 · Cited by 162 · see citing works
Serotonin transporter binding in patients with mood disorders: a PET study with [11C](+)McN5652
Ichimiya, T., Suhara, T., Sudo, Y., Okubo, Y., Nakayama, K., Nankai, M., Inoue, M., Yasuno, F., Takano, A., Maeda, J., et al. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01351-8 · Cited by 153 · see citing works
Quantitative proton magnetic resonance spectroscopy of the basal ganglia in patients with affective disorders
Hamakawa, H., Kato, T., Murashita, J., & Kato, N. (1998) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s004060050017 · Cited by 153 · see citing works
Lower Concentration of Hippocampal N-Acetylaspartate in Familial Bipolar I Disorder
Deicken, R. F., Pegues, M., Anzalone, S., Feiwell, R., & Soher, B. J. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.5.873 · Cited by 153 · see citing works
Brain choline in depression: In vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy
Charles, H. C., Lazeyras, F., Krishnan, K. R. R., Boyko, O. B., Payne, M., & Moore, D. (1994) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(94)90115-5 · Cited by 145 · see citing works
Proton Magnetic Resonance Spectroscopy of Bipolar Disorder Versus Intermittent Explosive Disorder in Children and Adolescents
Davanzo, P. A., Yue, K. T. N., Thomas, M. A., Belin, T. R., Mintz, J., Venkatraman, T. N., Santoro, E., Barnett, S., & McCracken, J. T. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.8.1442 · Cited by 142 · see citing works
Magnetic Resonance Spectroscopy in Affective Disorders
Kato, T., Inubushi, T., & Kato, N. (1998) · Journal of Neuropsychiatry · doi:10.1176/jnp.10.2.133 · Cited by 135 · see citing works
Chronic treatment with lithium, but not sodium valproate, increases cortical N-acetyl-aspartate concentrations in euthymic bipolar patients
Silverstone, P. H., Wu, R., O'Donnell, T., Ulrich, M., Asghar, S., & Hanstock, C. C. (2003) · International Clinical Psychopharmacology · doi:10.1097/00004850-200303000-00002 · Cited by 135 · see citing works
An fMRI study of affective state and medication on cortical and subcortical brain regions during motor performance in bipolar disorder
Caligiuri, M. P., Brown, G. G., Meloy, M. J., Eberson, S., Kindermann, S. S., Frank, L. R., Zorrilla, L. T. E., & Lohr, J. B. (2003) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(03)00075-1 · Cited by 130 · see citing works
PET Study of [<sup>18</sup>F]6-Fluoro-<scp>l</scp>-Dopa Uptake in Neuroleptic- and Mood-Stabilizer-Naive First-Episode Nonpsychotic Mania: Effects of Treatment With Divalproex Sodium
Yatham, L. N., Liddle, P. F., Shiah, I.-S., Lam, R. W., Ngan, E., Scarrow, G., Imperial, M., Stoessl, J., Sossi, V., & Ruth, T. J. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.5.768 · Cited by 122 · see citing works
MRI study of posterior fossa structures and brain ventricles in bipolar patients
Brambilla, P., Harenski, K. A., Nicoletti, M., Mallinger, A. G., Frank, E., Kupfer, D. J., Keshavan, M. S., & Soares, J. C. (2001) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(01)00036-x · Cited by 117 · see citing works
Differential frontal activation in schizophrenia and bipolar illness during verbal fluency
Curtis, V. A., Dixon, T., Morris, R. G., Bullmore, E. T., Brammer, M. J., Williams, S., Sharma, T., Murray, R. M., & McGuire, P. K. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00240-8 · Cited by 114 · see citing works
Increased thalamic N-acetylaspartate in male patients with familial bipolar I disorder
Deicken, R. F., Eliaz, Y., Feiwell, R., & Schuff, N. W. (2001) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(00)00083-4 · Cited by 113 · see citing works
Basal ganglia choline levels in depression and response to fluoxetine treatment: An in vivo proton magnetic resonance spectroscopy study
Renshaw, P. F., Lafer, B., Babb, S. M., D, M. F. M., Stoll, A. L., Christensen, J. D., Moore, C. M., Yurgelun-Todd, D. A., Bonello, C. M., Pillay, S. S., et al. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00256-9 · Cited by 111 · see citing works
Anatomical MRI study of basal ganglia in bipolar disorder patients
Brambilla, P., Harenski, K. A., Nicoletti, M., Mallinger, A. G., Frank, E., Kupfer, D. J., Keshavan, M. S., & Soares, J. C. (2001) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(01)00073-7 · Cited by 109 · see citing works
Differential Effects of Age on Brain Gray Matter in Bipolar Patients and Healthy Individuals
Brambilla, P., Harenski, K. A., Nicoletti, M., Mallinger, A. G., Frank, E., Kupfer, D. J., Keshavan, M. S., & Soares, J. C. (2001) · Neuropsychobiology · doi:10.1159/000054897 · Cited by 98 · see citing works
MRI study of thalamic volumes in bipolar and unipolar patients and healthy individuals
Caetano, S. C., Sassi, R. B., Brambilla, P., Harenski, K. A., Nicoletti, M., Mallinger, A. G., Frank, E., Kupfer, D. J., Keshavan, M. S., & Soares, J. C. (2001) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(01)00123-8 · Cited by 91 · see citing works
31P Nuclear magnetic resonance spectroscopy findings in bipolar illness: a meta-analysis
Yıldız, A., Sachs, G. S., Dorer, D. J., et al. (2001) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(01)00082-8 · Cited by 89 · see citing works
Single‐Photon Emission Computed Tomography of the Brain in Acute Mania and Schizophrenia
O’Connell, R. A., Heertum, R. L. V., Luck, D., Yudd, A. P., Cueva, J. E., Billick, S. B., Cordon, D., Gersh, R. J., & Masdeu, J. C. (1995) · Journal of Neuroimaging · doi:10.1111/jon199552101 · Cited by 87 · see citing works
Proton magnetic resonance spectroscopy of the lenticular nuclei in bipolar I affective disorder
Ohara, K., & Ohara, K. (1998) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(98)00050-x · Cited by 82 · see citing works
Chronic treatment with both lithium and sodium valproate may normalize phosphoinositol cycle activity in bipolar patients
Silverstone, P. H., Wu, R., O'Donnell, T., et al. (2002) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.420 · Cited by 82 · see citing works
PET study of the effects of valproate on dopamine D(2) receptors in neuroleptic- and mood-stabilizer-naive patients with nonpsychotic mania.
Yatham, L., Liddle, P., Lam, R. W., Shiah, I., Lane, C. J., Stoessl, A., Sossi, V., & Ruth, T. J. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.10.1718 · Cited by 80 · see citing works
Diagnostic specificity of focal white matter abnormalities in bipolar and unipolar mood disorder
Dupont, R. M., Butters, N., Schafer, K. A., Wilson, T., Hesselink, J. R., & Gillin, J. C. (1995) · Biological Psychiatry · doi:10.1016/0006-3223(95)00100-u · Cited by 78 · see citing works
Meta-analysis of brain size in bipolar disorder
Hoge, E. A., Friedman, L., & Schulz, S. C. (1999) · Schizophrenia Research · doi:10.1016/s0920-9964(98)00149-2 · Cited by 69 · see citing works
Brain lithium concentrations in bipolar disorder patients: preliminary 7Li magnetic resonance studies at 3 T
Soares, J. C., Boada, F. E., Spencer, S. J., et al. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00985-9 · Cited by 64 · see citing works
Brain Imaging in Affective Disorders
Soares, J. C. (2002) · CRC Press eBooks · doi:10.1201/b14093 · Cited by 42 · see citing works
Dopamine receptor binding of C-11-3-N-methylspiperone in the caudate in schizophrenia and bipolar disorder: a preliminary report.
Wong, D. F., Wagner, H. N., Pearlson, G. D., Dannals, R. F., Links, J. M., Ravert, H. T., Wilson, A. A., Suneja, S., Bjorvvinssen, E., & Kuhar, M. J. (1985) · PubMed · Cited by 41 · see citing works
Oral choline decreases brain purine levels in lithium-treated subjects with rapid-cycling bipolar disorder: A double-blind trial using proton and lithium magnetic resonance spectroscopy
Lyoo, I. K., Demopulos, C. M., Hirashima, F., Ahn, K. H., & Renshaw, P. F. (2003) · Bipolar Disorders · doi:10.1034/j.1399-5618.2003.00041.x · Cited by 33 · see citing works
Brain Anatomic Circuits and the Pathophysiology of Affective Disorders
Soares, J. C. (2002) · CRC Press eBooks · doi:10.1201/b14093-9 · Cited by 6 · see citing works

Flagged first, then by citations

Sorted by citations

A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder
Phillips, M. L., Ladouceur, C. D., & Drevets, W. C. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.65 · Cited by 1,383 · see citing works
Chromatin marks identify critical cell types for fine mapping complex trait variants
Trynka, G., Sandor, C., Han, B., Xu, H., Stranger, B. E., Liu, X. S., & Raychaudhuri, S. (2013) · Nature Genetics · doi:10.1038/ng.2504 · Cited by 580 · see citing works
Emotional information processing in mood disorders: a review of behavioral and neuroimaging findings
Leppänen, J. M. (2006) · Current Opinion in Psychiatry · doi:10.1097/01.yco.0000191500.46411.00 · Cited by 632 · see citing works
Anatomy of bipolar disorder and schizophrenia: A meta-analysis
Ellison-Wright, I., & Bullmore, E. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2009.12.022 · Cited by 565 · see citing works
The limbic system
RajMohan, V, & Mohandas, E. (2007) · Indian Journal of Psychiatry · doi:10.4103/0019-5545.33264 · Cited by 342 · see citing works
Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings
Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works
Global Prefrontal and Fronto-Amygdala Dysconnectivity in Bipolar I Disorder with Psychosis History
Anticevic, A., Brumbaugh, M. S., Winkler, A. M., Lombardo, L. E., Barrett, J., Corlett, P. R., Kober, H., Gruber, J., Repovs, G., Cole, M. W., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.07.031 · Cited by 263 · see citing works
Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology
Abazyan, B., Nomura, J., Kannan, G., Ishizuka, K., Tamashiro, K. L., Nucifora, F., Pogorelov, V., Ladenheim, B., Yang, C., Krasnova, I. N., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.022 · Cited by 255 · see citing works
Biomarkers in bipolar disorder: a positional paper from the international society for bipolar disorders biomarkers task force.
Frey, B. N., Andreazza, A. C., Houenou, J., Jamain, S., Goldstein, B. I., Frye, M. A., Leboyer, M., Berk, M., Malhi, G. S., Lopez-Jaramillo, C., et al. (2013) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867413478217 · Cited by 234 · see citing works
Fronto-Striatal Overactivation in Euthymic Bipolar Patients During an Emotional Go/NoGo Task
Wessa, M., Houenou, J., Paillère-Martinot, M.-L., Berthoz, S., Artiges, E., Leboyer, M., & Martinot, J.-L. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.4.638 · Cited by 225 · see citing works
Cortical abnormalities in bipolar disorder investigated with MRI and voxel-based morphometry
Nugent, A. C., Milham, M. P., Bain, E. E., Mah, L., Cannon, D. M., Marrett, S., Zarate, C. A., Pine, D. S., Price, J. L., & Drevets, W. C. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.09.029 · Cited by 206 · see citing works
An update on regional brain volume differences associated with mood disorders
Campbell, S., & MacQueen, G. (2006) · Current Opinion in Psychiatry · doi:10.1097/01.yco.0000194371.47685.f2 · Cited by 198 · see citing works
Is a lack of disgust something to fear? A functional magnetic resonance imaging facial emotion recognition study in euthymic bipolar disorder patients
Malhi, G. S., Lagopoulos, J., Sachdev, P. S., Ivanovski, B., Shnier, R., & Ketter, T. (2007) · Bipolar Disorders · doi:10.1111/j.1399-5618.2007.00485.x · Cited by 155 · see citing works
Striatal dopamine transporter availability in unmedicated bipolar disorder: Striatal DAT in unmedicated bipolar disorder
Anand, A., Barkay, G., Dzemidzic, M., Albrecht, D., Karne, H., Zheng, Q.-H., Hutchins, G. D., Normandin, M. D., & Yoder, K. K. (2011) · Bipolar Disorders · doi:10.1111/j.1399-5618.2011.00936.x · Cited by 139 · see citing works
Animal models of bipolar mania: The past, present and future
Logan, R. W., & McClung, C. A. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.041 · Cited by 136 · see citing works
Identify changes of brain regional homogeneity in bipolar disorder and unipolar depression using resting-state FMRI
Liang, M.-J., Zhou, Q., Yang, K.-R., Yang, X.-L., Fang, J., Chen, W.-L., & Huang, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079999 · Cited by 135 · see citing works
Relationship between suicidality and impulsivity in bipolar I disorder: a diffusion tensor imaging study
Mahon, K., Burdick, K. E., Wu, J., Ardekani, B. A., & Szeszko, P. R. (2012) · Bipolar Disorders · doi:10.1111/j.1399-5618.2012.00984.x · Cited by 131 · see citing works
The Future of Neuroimplantable Devices: A Materials Science and Regulatory Perspective
Obidin, N., Tasnim, F., & Dagdeviren, C. (2020) · Advanced Materials · doi:10.1002/adma.201901482 · Cited by 126 · see citing works
Exaggerated neural response to emotional faces in patients with bipolar disorder and their first-degree relatives
Surguladze, S. A., Marshall, N., Schulze, K., Hall, M.-H., Walshe, M., Bramon, E., Phillips, M. L., Murray, R. M., & McDonald, C. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.05.069 · Cited by 126 · see citing works
The functional neuroanatomy of bipolar disorder
Cerullo, M. A., Adler, C. M., Delbello, M. P., & Strakowski, S. M. (2009) · International Review of Psychiatry · doi:10.1080/09540260902962107 · Cited by 113 · see citing works
Self-citation
Decreased cerebral blood flow in the limbic and prefrontal cortex using SPECT imaging in a cohort of completed suicides
Willeumier, K., Taylor, D. V., & Amen, D. G. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.28 · Cited by 107 · see citing works
Dynamic functional connectivity in bipolar disorder is associated with executive function and processing speed: A preliminary study
Nguyen, T. T., Kovacevic, S., Dev, S. I., Lu, K., Liu, T. T., & Eyler, L. T. (2017) · Neuropsychology · doi:10.1037/neu0000317 · Cited by 109 · see citing works
Effects of mood stabilizers on hippocampus and amygdala BDNF levels in an animal model of mania induced by ouabain
Jornada, L. K., Moretti, M., Valvassori, S. S., Ferreira, C. L., Padilha, P. T., Arent, C. O., Fries, G. R., Kapczinski, F., & Quevedo, J. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.11.002 · Cited by 107 · see citing works
Cerebellar-motor dysfunction in schizophrenia and psychosis-risk: The importance of regional cerebellar analysis approaches
Bernard, J. A., & Mittal, V. A. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00160 · Cited by 100 · see citing works
The psychoses: Cluster 3 of the proposed meta-structure for DSM-V and ICD-11: Paper 4 of 7 of the thematic section: ‘A proposal for a meta-structure for DSM-V and ICD-11’
Carpenter, W. T., Bustillo, J. R., Thaker, G. K., van Os, J., Krueger, R. F., & Green, M. J. (2009) · Psychological Medicine · doi:10.1017/s0033291709990286 · Cited by 99 · see citing works
Brain changes in early-onset bipolar and unipolar depressive disorders: a systematic review in children and adolescents
Serafini, G., Pompili, M., Borgwardt, S., Houenou, J., Geoffroy, P. A., Jardri, R., Girardi, P., & Amore, M. (2014) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-014-0614-z · Cited by 94 · see citing works
Illness duration and total brain gray matter in bipolar disorder: Evidence for neurodegeneration?
Frey, B. N., Zunta-Soares, G. B., Caetano, S. C., Nicoletti, M. A., Hatch, J. P., Brambilla, P., Mallinger, A. G., & Soares, J. C. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.04.015 · Cited by 79 · see citing works
Disturbance in long distance gamma coherence in bipolar disorder
Özerdem, A., Güntekin, B., Saatçi, E., Tunca, Z., & Başar, E. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.04.001 · Cited by 75 · see citing works
Fronto-limbic circuitry in euthymic bipolar disorder: Evidence for prefrontal hyperactivation
Robinson, J. L., Monkul, E. S., Tordesillas-Gutiérrez, D., Franklin, C., Bearden, C. E., Fox, P. T., & Glahn, D. C. (2008) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2007.12.004 · Cited by 75 · see citing works
Overlapping prefrontal systems involved in cognitive and emotional processing in euthymic bipolar disorder and following sleep deprivation: A review of functional neuroimaging studies
McKenna, B. S., & Eyler, L. T. (2012) · Clinical Psychology Review · doi:10.1016/j.cpr.2012.07.003 · Cited by 69 · see citing works
A dimensional approach to modeling symptoms of neuropsychiatric disorders in the marmoset monkey
Oikonomidis, L., Santangelo, A. M., Shiba, Y., Clarke, F. H., Robbins, T. W., & Roberts, A. C. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22446 · Cited by 54 · see citing works
Neurocognitive disorders: Cluster 1 of the proposed meta-structure for DSM-V and ICD-11: Paper 2 of 7 of the thematic section: ‘A proposal for a meta-structure for DSM-V and ICD-11’
Sachdev, P., Andrews, G., Hobbs, M. J., Sunderland, M., & Anderson, T. M. (2009) · Psychological Medicine · doi:10.1017/s0033291709990262 · Cited by 48 · see citing works
Functional Magnetic Resonance Imaging Studies in Bipolar Disorder
Yurgelun-Todd, D. A., & Ross, A. J. (2006) · CNS Spectrums · doi:10.1017/s1092852900020782 · Cited by 44 · see citing works
Oxytocin receptor mRNA expression in dorsolateral prefrontal cortex in major psychiatric disorders: A human post-mortem study
Lee, M. R., Sheskier, M. B., Farokhnia, M., Feng, N., Marenco, S., Lipska, B. K., & Leggio, L. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.05.039 · Cited by 44 · see citing works
Comparison of insight among schizophrenia and bipolar disorder patients in remission of affective and positive symptoms: Analysis and critique
Braw, Y., Sitman, R., Sela, T., Erez, G., Bloch, Y., & Levkovitz, Y. (2012) · European Psychiatry · doi:10.1016/j.eurpsy.2011.02.002 · Cited by 36 · see citing works
Cerebro-cerebellar white matter connectivity in bipolar disorder and associated polarity subphenotypes
Argyropoulos, G. D., Christidi, F., Karavasilis, E., Velonakis, G., Antoniou, A., Bede, P., Seimenis, I., Kelekis, N., Douzenis, A., Papakonstantinou, O., et al. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110034 · Cited by 24 · see citing works
Differential impairment of source memory in progressive versus non-progressive behavioral variant frontotemporal dementia
Irish, M., Graham, A., Graham, K. S., Hodges, J. R., & Hornberger, M. (2012) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acs033 · Cited by 20 · see citing works
Protein Kinase C Activity and Delayed Recovery of Sleep-Wake Cycle in Mouse Model of Bipolar Disorder
Moon, E., Choe, B.-M., Park, J.-M., Chung, Y. I., Lee, B. D., Park, J.-H., Lee, Y. M., Jeong, H. J., Cheon, Y., Choi, Y., et al. (2018) · Psychiatry Investigation · doi:10.30773/pi.2018.05.23 · Cited by 8 · see citing works
Posterior Fossa Sub-Arachnoid Cysts Observed in Patients with Bipolar Disorder: a Retrospective Cohort Study
Ewald, V. A. M., Purnell, J. R., Bruss, J. E., Barsotti, E. J., Aldine, A. S., Mahachi, K. G., Wemmie, J. A., Magnotta, V. A., Boes, A. D., Parker, K. L., et al. (2022) · The Cerebellum · doi:10.1007/s12311-022-01408-1 · Cited by 2 · see citing works

Authors: Strakowski, S. M., DelBello, M. P., & Adler, C. M.
Affiliations: University of Cincinnati (US)
Corresponding author: Strakowski, S M
ORCID: Strakowski, S M
DelBello, M P
Adler, C M
Venue: Molecular Psychiatry
Publisher: Springer Science and Business Media LLC
Published: 2004-08-31
Volume: 10
Issue: 1
Pages: 105-116
ISSN: 1359-4184 (ISSN-L)
1476-5578
DOI: 10.1038/sj.mp.4001585
OpenAlex: W1995907546
Cited by: 818
References: 87
Citations by year: 2026: 11 · 2025: 22 · 2024: 15 · 2023: 21 · 2022: 22 · 2021: 44 · 2020: 33 · 2019: 31 · 2018: 41 · 2017: 32 · 2016: 36 · 2015: 34 · 2014: 45 · 2013: 48 · 2012: 64
FWCI: 4.29
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Molecular Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: bipolar disorder, functional neuroanatomy, structural MRI, magnetic resonance spectroscopy, prefrontal cortex, striatum, amygdala, cerebellar vermis, mood dysregulation, affective episodes
MeSH terms: Bipolar Disorder, Brain, Brain Mapping, Cerebellum, Humans, Magnetic Resonance Imaging, Temporal Lobe, Prefrontal Cortex

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The functional neuroanatomy of bipolar disorder: a review of neuroimaging findings

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks