Is alexithymia a personality trait increasing the risk of depression? A prospective study evaluating alexithymia before, during and after a depressive episode
Abstract
Background: Whether alexithymia is a personality trait that increases the risk of major depression (MD) is still debated. In this prospective study, alexithymic levels were evaluated before, during and after a depressive episode. Method: The alexithymic levels, the presence of MD and the severity of anxious-depressive symptoms were evaluated at intervals of about 1 month in pregnant women attending the Centers for Prenatal Care, using the Toronto Alexithymia Scale (TAS), the Primary Care Evaluation of Mental Disorders (PRIME-MD) and the Hospital Anxiety and Depression Scale (HADS). Results: Sixteen women affected by MD, 21 affected by subthreshold depression and 112 non-depressed women were included in the study. Women who developed depression, compared to non-depressed women, showed similar TAS and HADS scores during the pre-morbid phase, a significant increase in the scores during depression and a significant decrease after remission, whereas no change was observed in non-depressed women. Conclusions: Our data suggest that in pregnant women alexithymia does not represent a personality trait that increases the risk of developing a depressive episode, and they support the hypothesis that alexithymia is a state-dependent phenomenon in depressed pregnant women.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Alexithymia (low emotional awareness) is a state-dependent feature of current depression.
“alexithymia (cf low emotional awareness) is a state-dependent feature of current depression (Marchesi, Bertoni, Cantoni, & Maggini, 2008)”
From Facets of Mindfulness in Adults with Generalized Anxiety Disorder and Impact of Co-occurring Depression (2019) · cites this paper as Marchesi, Bertoni, Cantoni, & Maggini, 2008
Cites
The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139 · see citing works
Bagby, R. M., Parker, J. D. A., & Taylor, G. J. (1994) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(94)90005-1 · Cited by 5,293 · see citing works
Utility of a new procedure for diagnosing mental disorders in primary care. The PRIME-MD 1000 study
Spitzer, R. L. (1994) · JAMA · doi:10.1001/jama.272.22.1749 · Cited by 2,648 · see citing works
Utility of a New Procedure for Diagnosing Mental Disorders in Primary Care: The PRIME-MD 1000 Study
Spitzer, R. L. (1994) · JAMA · doi:10.1001/jama.1994.03520220043029 · Cited by 1,873 · see citing works
Bressi, C., Taylor, G. J., Parker, J. D. A., Bressi, S., Brambilla, V., Aguglia, E., Allegranti, I., Bongiorno, A., Giberti, F., Bucca, M., et al. (1996) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(96)00228-0 · Cited by 670 · see citing works
New Trends in Alexithymia Research
Taylor, G. J., & Bagby, R. M. (2004) · Psychotherapy and Psychosomatics · doi:10.1159/000075537 · Cited by 653 · see citing works
Emotion-processing deficits in eating disorders
Bydlowski, S., Corcos, M., Jeammet, P., Paterniti, S., Berthoz, S., Laurier, C., Chambry, J., & Consoli, S. M. (2005) · International Journal of Eating Disorders · doi:10.1002/eat.20132 · Cited by 348 · see citing works
Luminet, O., Bagby, R. M., & Taylor, G. J. (2001) · Psychotherapy and Psychosomatics · doi:10.1159/000056263 · Cited by 288 · see citing works
Alexithymia and Depression: A Prospective Study of Patients With Major Depressive Disorder
Honkalampi, K. M., Hintikka, J. J., Laukkanen, E., & Viinamäki, J. L. H. (2001) · Psychosomatics · doi:10.1176/appi.psy.42.3.229 · Cited by 249 · see citing works
Are alexithymia, depression, and anxiety distinct constructs in affective disorders?
Marchesi, C., Brusamonti, E., & Maggini, C. (2000) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(00)00084-2 · Cited by 227 · see citing works
Self-citationSaarijãrvi, S., Salminen, J. K., & Toikka, T. (2001) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(01)00257-4 · Cited by 212 · see citing works
Alexithymia and negative emotional conditions
Lumley, M. A. (2000) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(00)00161-6 · Cited by 161 · see citing works
Is Alexithymia a Permanent Feature in Depressed Patients?
Honkalampi, K. M., Hintikka, J., Saarinen, P., Lehtonen, J., & Viinamäki, H. T. (2000) · Psychotherapy and Psychosomatics · doi:10.1159/000012412 · Cited by 157 · see citing works
Temporal Stability of Alexithymia Over a Five-Year Period in Outpatients with Major Depression
Saarijärvi, S., Salminen, J. K., & Toikka, T. (2006) · Psychotherapy and Psychosomatics · doi:10.1159/000090895 · Cited by 154 · see citing works
Are alexithymia and depression distinct or overlapping constructs?: A study in a general population
Hintikka, J. J., Honkalampi, K. M., Lehtonen, J., & Viinamäki, H. T. (2001) · Comprehensive Psychiatry · doi:10.1053/comp.2001.23147 · Cited by 143 · see citing works
Relationship between Alexithymia and Panic Disorder: A Longitudinal Study to Answer an Open Question
Marchesi, C., Fontò, S., Balista, C., Cimmino, C., & Maggini, C. (2004) · Psychotherapy and Psychosomatics · doi:10.1159/000082028 · Cited by 118 · see citing works
Self-citationIs alexithymia affected by situational stress or is it a stable trait related to emotion regulation?
Mikolajczak, M., & Luminet, O. (2006) · Personality and Individual Differences · doi:10.1016/j.paid.2005.10.020 · Cited by 108 · see citing works
Why Do Alexithymic Features Appear to Be Stable?
Honkalampi, K. M., Koivumaa-Honkanen, H. T., Tanskanen, A. J., Hintikka, J. J., Lehtonen, J., & Viinamäki, H. T. (2001) · Psychotherapy and Psychosomatics · doi:10.1159/000056262 · Cited by 104 · see citing works
Alexithymia, depressive experiences and dependency in addictive disorders
Speranza, M., Corcos, M., Stéphan, P., Loas, G., Pérez-Diaz, F., Lang, F., Venisse, J. L., Bizouard, P., Flament, M., Halfon, O., et al. (2004) · Substance Use & Misuse · doi:10.1081/ja-120030058 · Cited by 74 · see citing works
Honkalampi, K. M., Hintikka, J. J., Antikainen, R., Lehtonen, J., & Viinamäki, H. T. (2001) · Journal of Personality Disorders · doi:10.1521/pedi.15.3.245.19211 · Cited by 63 · see citing works
Honkalampi, K. M., Koivumaa-Honkanen, H. T., Antikainen, R., Haatainen, K. M., Hintikka, J. J., & Viinamäki, H. T. (2004) · Psychosomatics · doi:10.1176/appi.psy.45.3.197 · Cited by 52 · see citing works
The relationship between alexithymia and perinatal depressive symptomatology
Le, H. N., Ramos, M. A., & Muñoz, R. F. (2007) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2006.09.012 · Cited by 47 · see citing works
State and Personality in Agoraphobic Patients
Hoffart, A. (1994) · Journal of Personality Disorders · doi:10.1521/pedi.1994.8.4.333 · Cited by 20 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Li, S., Zhang, B., Guo, Y., & Zhang, J. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.02.006 · Cited by 350 · see citing works
The alexithymic brain: the neural pathways linking alexithymia to physical disorders
Kano, M., & Fukudo, S. (2013) · BioPsychoSocial Medicine · doi:10.1186/1751-0759-7-1 · Cited by 196 · see citing works
Stability of alexithymia in the general population: an 11-year follow-up
Tolmunen, T., Heliste, M., Lehto, S. M., Hintikka, J., Honkalampi, K., & Kauhanen, J. (2011) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2010.09.007 · Cited by 156 · see citing works
Iskric, A., Ceniti, A. K., Bergmans, Y., McInerney, S. J., & Rizvi, S. J. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2020.112920 · Cited by 117 · see citing works
Kojima, M. (2012) · BioPsychoSocial Medicine · doi:10.1186/1751-0759-6-21 · Cited by 115 · see citing works
Honkalampi, K. M., Koivumaa-Honkanen, H. T., Lehto, S. M., Hintikka, J. J., Haatainen, K. M., Rissanen, T., & Viinamäki, H. T. (2009) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2009.05.010 · Cited by 111 · see citing works
Alexithymia Is Associated With Increased Cardiovascular Mortality in Middle-Aged Finnish Men
Tolmunen, T., Lehto, S. M., Heliste, M., Kurl, S., & Kauhanen, J. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181c65d00 · Cited by 94 · see citing works
Association of alexithymia and depression symptom severity in adults aged 50 years and older
Bamonti, P. M., Heisel, M. J., Topciu, R. A., Franus, N., Talbot, N. L., & Duberstein, P. R. (2010) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181bd1bfe · Cited by 90 · see citing works
Development of alexithymic personality features
Karukivi, M. (2014) · World Journal of Psychiatry · doi:10.5498/wjp.v4.i4.91 · Cited by 90 · see citing works
Emotional self-awareness in autism: A meta-analysis of group differences and developmental effects
Huggins, C. F., Donnan, G. L. J., Cameron, I. M., & Williams, J. H. G. (2020) · Autism · doi:10.1177/1362361320964306 · Cited by 73 · see citing works
Hiirola, A., Pirkola, S. P., Karukivi, M., Markkula, N., Bagby, R. M., Joukamaa, M. I., Jula, A., Kronholm, E., Saarijãrvi, S., Jk, S., et al. (2017) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2017.02.007 · Cited by 71 · see citing works
Berardis, D. D., Serroni, N., Campanella, D., Carano, A., Gambi, F., Valchera, A., Conti, C. M., Sepede, G., Scali, M., Fulcheri, M., et al. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.09.022 · Cited by 67 · see citing works
Relationship between alexithymia and depression
Sagar, R., Talwar, S., Desai, G., & Chaturvedi, S. K. (2021) · Indian Journal of Psychiatry · doi:10.4103/psychiatry.indianjpsychiatry_738_19 · Cited by 62 · see citing works
Prevalence and associated factors of alexithymia among Chinese adolescents in Hong Kong
Ng, C. S. M., & Chan, V. C. W. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2020.113126 · Cited by 49 · see citing works
Aaron, R. V., Snodgress, M. A., Blain, S. D., & Park, S. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.02.014 · Cited by 49 · see citing works
Taycan, O., Özdemir, A., & Taycan, S. E. (2016) · Nöro Psikiyatri Arşivi · doi:10.5152/npa.2016.12385 · Cited by 47 · see citing works
Finding words for feelings: The relationship between personality disorders and alexithymia
Panfilis, C. D., Ossola, P., Tonna, M., Catania, L., & Marchesi, C. (2014) · Personality and Individual Differences · doi:10.1016/j.paid.2014.10.050 · Cited by 42 · see citing works
Self-citationKick, L., Schleicher, D., Ecker, A., Kandsperger, S., Brunner, R. M., & Jarvers, I. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1412229 · Cited by 41 · see citing works
Self-Awareness in alexithymia and associations with social anxiety
Panayiotou, G., Leonidou, C., Constantinou, E., & Michaelides, M. P. (2018) · Current Psychology · doi:10.1007/s12144-018-9855-1 · Cited by 41 · see citing works
Sfärlea, A., Dehning, S., Keller, L. K., & Schulte‐Körne, G. (2019) · Journal of Eating Disorders · doi:10.1186/s40337-019-0271-1 · Cited by 40 · see citing works
Bilotta, E., Giacomantonio, M., Leone, L., Mancini, F., & Coriale, G. (2015) · Psychology and Psychotherapy Theory Research and Practice · doi:10.1111/papt.12079 · Cited by 39 · see citing works
Alexithymia traits outweigh autism traits in the explanation of depression in adults with autism
Bloch, C., Burghof, L., Lehnhardt, F., Vogeley, K. T., & Falter‐Wagner, C. M. (2021) · Scientific Reports · doi:10.1038/s41598-021-81696-5 · Cited by 39 · see citing works
Pei, J., Wang, X., Chen, H., Zhang, H., Nan, R., Zhang, J., & Dou, X. (2021) · BMC Nursing · doi:10.1186/s12912-021-00702-3 · Cited by 36 · see citing works
Tang, W.-C., Lin, M., Wu, J. Y., Lee, Y., & You, J. (2022) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/s13034-022-00477-8 · Cited by 36 · see citing works
The implication of alexithymia in personality disorders: a systematic review
Chaim, C. H., Almeida, T. M., Albertin, P. D. V., Santana, G. L., Siu, E. R., & Andrade, L. H. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-06083-6 · Cited by 29 · see citing works
Montebarocci, O., & Surcinelli, P. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.09.036 · Cited by 29 · see citing works
Alexithymia as a Screening Index for Male Conscripts with Adjustment Disorder
Chen, P., Chen, C., Chen, C., & Lung, F. (2010) · Psychiatric Quarterly · doi:10.1007/s11126-010-9156-9 · Cited by 27 · see citing works
Huggins, C. F., Donnan, G. L. J., Cameron, I. M., & Williams, J. H. G. (2020) · Research in Autism · doi:10.1016/j.rasd.2020.101612 · Cited by 26 · see citing works
Cerutti, R., Spensieri, V., Presaghi, F., Renzi, A., Palumbo, N., Amendola, S., Solano, L., & Trani, M. D. (2020) · Psychiatric Quarterly · doi:10.1007/s11126-020-09715-8 · Cited by 23 · see citing works
Emery, N. N., Walters, K. J., Njeim, L., Barr, M., Gelman, D., & Eddie, D. (2022) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14854 · Cited by 21 · see citing works
Alexithymia and fertility-related stress
Gourounti, K., Anagnostopoulos, F., Griva, F., & Βασλαματζής, Γ. (2015) · Women & Health · doi:10.1080/03630242.2015.1088119 · Cited by 19 · see citing works
Duarte, J., & Pinto‐Gouveia, J. (2016) · Journal of Contextual Behavioral Science · doi:10.1016/j.jcbs.2016.12.002 · Cited by 17 · see citing works
Preece, D. A., & Gross, J. J. (2024) · Personality and Individual Differences · doi:10.1016/j.paid.2024.112732 · Cited by 16 · see citing works
Xie, Y., Ma, D., Duan, Y., Cao, J., & Wei, J. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-05902-0 · Cited by 15 · see citing works
Alexithymia and Cancer-Related Fatigue: A Controlled Cross-Sectional Study
Gritti, P., Lombardi, S., Nobile, B., P., T., Gambardella, A., CAPRIO, E. L. D., & Resicato, G. (2010) · Tumori Journal · doi:10.1177/030089161009600121 · Cited by 15 · see citing works
The effect of alexithymia on depression: evidence from meta-analysis
Liu, Z., He, S., & Hou, C. (2025) · Frontiers in Psychology · doi:10.3389/fpsyg.2025.1465286 · Cited by 14 · see citing works
ALEXITHYMIA IN PREGNANT WOMEN: ITS RELATIONSHIP WITH DEPRESSION
Gilanifar, M., & Delavar, M. A. (2016) · ASEAN Journal of Psychiatry · Cited by 14 · see citing works
Landeghem, C. V., & Jakobson, L. S. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1330483 · Cited by 12 · see citing works
Marchesi, C., Ossola, P., Scagnelli, F., Mellini, L., Tonna, M., Ardissino, D., & Panfilis, C. D. (2015) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2015.06.013 · Cited by 11 · see citing works
Self-citationErtekin, E., Koyuncu, A., Ertekin, B. A., & Özyıldırım, İ. (2014) · Anatolian Journal of Psychiatry · doi:10.5455/apd.153110 · Cited by 11 · see citing works
Is Alexithymia a Trait or a State? Temporal Stability in a Three-Wave Longitudinal Study
Larionow, P., Mudło‐Głagolska, K., & Preece, D. A. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14082628 · Cited by 10 · see citing works
Stress levels in psychosis: Do body and mind diverge?
Söder, E., Clamor, A., Kempkensteffen, J., Moritz, S., & Lincoln, T. M. (2018) · Biological Psychology · doi:10.1016/j.biopsycho.2018.08.016 · Cited by 10 · see citing works
Baker, A. W., Frumkin, M. R., Hoeppner, S. S., LeBlanc, N. J., Bui, E., Hofmann, S. G., & Simon, N. M. (2019) · Mindfulness · doi:10.1007/s12671-018-1059-0 · Cited by 9 · see citing works
Bram, A. D., Gottschalk, K. A., & Leeds, W. M. (2018) · Journal of the American Psychoanalytic Association · doi:10.1177/0003065118798043 · Cited by 8 · see citing works
LARSSON, M. R., Bäckström, M., Michel, P., & Lundh, L. (2010) · Scandinavian Journal of Psychology · doi:10.1111/j.1467-9450.2010.00807.x · Cited by 8 · see citing works
Vlisides‐Henry, R. D. (2024) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-024-06812-5 · Cited by 7 · see citing works
D’Agostino, A., Manganelli, E., Aportone, A., Monti, M. R., & Starčević, V. (2016) · CINECA IRIS Institutional Research information system (University of Urbino) · Cited by 7 · see citing works
Alqahtani, M. M. J. (2015) · Postępy Psychiatrii i Neurologii · doi:10.1016/j.pin.2015.11.003 · Cited by 6 · see citing works
Depressive comorbidity in personality disorders
Vilaplana, M., McKenney, K., Riesco, M. D., Autonell, J., & Cervilla, J. A. (2010) · Revista de Psiquiatría y Salud Mental (English Edition) · doi:10.1016/s2173-5050(10)70002-9 · Cited by 6 · see citing works
Comorbilidad depresiva en los trastornos de la personalidad
Vilaplana, M., Mckenney, K., Riesco, M. D., Autonell, J., & Cervilla, J. A. (2010) · Revista de Psiquiatría y Salud Mental · doi:10.1016/s1888-9891(10)70002-1 · Cited by 5 · see citing works
Tian, Y., Cui, Y., Liu, L., Chen, C., Liu, Z., Li, W., Wang, J., Luo, X., Wen, X., Yang, C., et al. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-07271-8 · Cited by 5 · see citing works
Comparative study of alexithymia in institutionalized elderly versus senior classroom
García-Sevilla, J., Méndez, I., Bermúdez, A. M., & Martínez, J. P. (2015) · European Journal of Investigation in Health Psychology and Education · doi:10.1989/ejihpe.v6i1.144 · Cited by 4 · see citing works
What role does personality play in cardiovascular disease?
Jackson, A. C., Ski, C. F., Murphy, B. M., Fernández, E., Alvarenga, M. E., Grande, M. R. L., & Thompson, D. R. (2018) · British Journal of Cardiac Nursing · doi:10.12968/bjca.2018.13.7.330 · Cited by 4 · see citing works
Secondary Traumatic Stress and Alexithymia in High-Risk Professionals
Vandermeer, M. R. J. (2014) · Scholarship@Western (Western University) · Cited by 3 · see citing works
Assessment of alexithymia and cognition in elderly patients with depression
Faye, A. D., Tadke, R., Gawande, S., Bhave, S. H., Kirpekar, V., & Chatterjee, A. (2022) · Journal of Geriatric Mental Health · doi:10.4103/jgmh.jgmh_41_22 · Cited by 1 · see citing works
Alexithymie bij depressieve ouderen: een relevante persoonlijkheidstrek?
Mooi, B., Comijs, H. C., Cladder, M. A., & Beekman, A. T. F. (2010) · Tijdschrift voor Gerontologie en Geriatrie · doi:10.1007/bf03096194 · Cited by 1 · see citing works
Xie, Y., Ma, D., Duan, Y., 曹锦亚, & Wei, J. (2024) · Figshare · doi:10.6084/m9.figshare.26736033
Alexithymia: Current status and future prospects
Preece, D. A., & Gross, J. J. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.122516
- Authors
- Marchesi, C., Bertoni, S., Cantoni, A., & Maggini, C.
- Affiliations
- University of Parma (IT)
- Corresponding author
- Marchesi, C.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2008-03-26
- Volume
- 38
- Issue
- 12
- Pages
- 1717-1722
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2140239886
- Cited by
- 61
- References
- 23
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 8 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 1 · 2018: 7 · 2017: 1 · 2016: 4 · 2015: 6 · 2014: 4 · 2013: 1 · 2012: 1
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- alexithymia, major depressive disorder, personality traits, pregnancy, subthreshold depression, depressive episodes, remission, anxiety symptoms, risk factors for depression
- MeSH terms
- Adolescent, Adult, Affective Symptoms, Major Depressive Disorder, Female, Humans, Personality Inventory, Prospective Studies, Surveys and Questionnaires, Risk Factors, Severity of Illness Index, Time Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review