The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Association of the 5-HTTLPR genotype and unipolar depression: a meta-analysis
Abstract
Background: We sought to ascertain the strength of evidence for association between the 5-HTTLPR polymorphism and unipolar depression. Method: We applied meta-analytic techniques to data from relevant published studies, and obtained an estimate of the likely magnitude of effect of any association. We also tested for possible publication bias, and explored the impact of various study design characteristics on the magnitude of the observed effect size. Results: Meta-analysis indicated evidence of a small but statistically significant association between the 5-HTTLPR polymorphism and unipolar depression [odds ratio (OR) 1.08, 95% confidence interval (CI) 1.03–1.12]. This remained significant when data from samples of European and East Asian ancestry were analyzed separately. In all cases there was evidence of significant between-study heterogeneity, although the observed associations were robust to the application of a random-effects framework. Conclusions: Our results support the presence of a small effect of a polymorphism in the serotonin transporter promoter on susceptibility to depression. However, we caution that it is possible that the effect has an artifactual basis, rather than a biological origin.
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Faul, F., Erdfelder, E., Lang, A.-G., & Buchner, A. (2007) · Behavior Research Methods · doi:10.3758/bf03193146 · Cited by 65,971
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120
Allelic Variation of Human Serotonin Transporter Gene Expression
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Social Adversity, the Serotonin Transporter (5-HTTLPR) Polymorphism and Major Depressive Disorder
Surtees, P. G., Wainwright, N. W. J., Willis-Owen, S. A. G., Luben, R., Day, N. E., & Flint, J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.07.014 · Cited by 265
Self-citationChipman, P., Jorm, A. F., Prior, M., Sanson, A., Smart, D., Tan, X., & Easteal, S. (2007) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30480 · Cited by 81
Cited by
The Genetics of Major Depression
Flint, J., & Kendler, K. S. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.027 · Cited by 724
Self-citationSocial functioning in major depressive disorder
Kupferberg, A., Bicks, L., & Hasler, G. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.002 · Cited by 663
Cognitive Mechanisms of Treatment in Depression
Roiser, J. P., Elliott, R., & Sahakian, B. J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.183 · Cited by 535
Martel, M. M. (2013) · Psychological Bulletin · doi:10.1037/a0032247 · Cited by 326
Meta-analysis of molecular imaging of serotonin transporters in major depression
Gryglewski, G., Lanzenberger, R., Kranz, G. S., & Cumming, P. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.82 · Cited by 227
Metadata
- Authors
- Clarke, H., Flint, J., Attwood, A. S., & Munafò, M. R.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2010-04-12
- Volume
- 40
- Issue
- 11
- Pages
- 1767-1778
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W1966865235
- Cited by
- 175
- References
- 11
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Clarke, H., Flint, J., Attwood, A. S., & Munafò, M. R. (2010). Association of the 5-HTTLPR genotype and unipolar depression: a meta-analysis. Psychological Medicine. https://doi.org/10.1017/s0033291710000516
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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