No interaction between the serotonin transporter polymorphism (5‐HTTLPR) and childhood adversity or recent stressful life events on symptoms of depression: Results from two community surveys

Chipman, P.; Jorm, A.F.; Prior, M.; Sanson, A.; Smart, D.; Tan, X.; Easteal, S.

doi:10.1002/ajmg.b.30480

Cited by 81Neurotransmitter Receptor Influence on BehaviorGenetic Associations and EpidemiologyChild and Adolescent Psychosocial and Emotional Development

No interaction between the serotonin transporter polymorphism (5‐HTTLPR) and childhood adversity or recent stressful life events on symptoms of depression: Results from two community surveys

Chipman, P., Jorm, A.F., Prior, M., Sanson, A., Smart, D., Tan, X., Easteal, S.·2007·American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

DOI 10.1002/ajmg.b.30480

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Abstract

In this study we investigated interactions between the 5-HTTLPR genotype and environmental risk factors (G x E) on symptoms of depression in two large Australian community samples of adolescents and young adults. We postulated that a significant interaction between the 5-HTTLPR genotype and environmental risk factors of childhood adversity or stressful life events on symptoms of depression would be observed in subjects with at least one short allele (s/l or s/s) compared with subjects with no short alleles (l/l). We did not find significant G x E interactions between the 5-HTTLPR genotype and recent stressful life events or childhood adversity on symptoms of depression in our sample populations. However, we did find adolescents aged 17-18 years homozygous for the long allele (l/l) and exposed to persistently high levels of family adversity over a 6-year period were at a greater risk of depression than subjects with the same genotype exposed to no or persistently low levels of family adversity. This interaction should be interpreted cautiously due to the small number of depressed subjects in the sample with persistently high levels of family adversity.

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In Chipman et al.'s replication sample, findings were limited because few adolescents with persistent adversity had high depressive symptoms, although the sample did not depart from Hardy-Weinberg equilibrium.
“Although the replication sample did not show a departure from HWE, as the authors noted, findings from the replication sample were limited by the fact that very few adolescents categorized as having persistent adversity had high levels of depressive symptoms.”
From Gene–environment interactions: early life stress and risk for depressive and anxiety disorders (2011) · cites this paper as Chipman et al. (2007)
In the first of two samples tested by Chipman et al. (2007), genotype frequencies were not in Hardy-Weinberg equilibrium, and no gene-environment interaction was detected.
“In the first of two samples tested by Chipman et al. (2007), genotype frequencies were not in HWE, and no GxE interaction was detected.”
From Gene–environment interactions: early life stress and risk for depressive and anxiety disorders (2011) · cites this paper as Chipman et al. (2007)

Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120 · see citing works
Behavioral inhibition, behavioral activation, and affective responses to impending reward and punishment: The BIS/BAS scales
Carver, C. S., & White, T. L. (1994) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.67.2.319 · Cited by 7,306 · see citing works
Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region
Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Müller, C. R., Hamer, D. H., & Murphy, D. L. (1996) · Science · doi:10.1126/science.274.5292.1527 · Cited by 5,162 · see citing works
A revised version of the Psychoticism scale
Eysenck, S. B. G., Eysenck, H. J., & Barrett, P. (1985) · Personality and Individual Differences · doi:10.1016/0191-8869(85)90026-1 · Cited by 3,094 · see citing works
Allelic Variation of Human Serotonin Transporter Gene Expression
Heils, A., Teufel, A., Petri, S., Stöber, G., Riederer, P., Bengel, D., & Lesch, K. P. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66062621.x · Cited by 2,221 · see citing works
Untitled work
(1995) · International Journal of Methods in Psychiatric Research · Cited by 1,847 · see citing works
Detecting anxiety and depression in general medical settings.
Goldberg, D., Bridges, K., Duncan-Jones, P., & Grayson, D. (1988) · BMJ · doi:10.1136/bmj.297.6653.897 · Cited by 1,210 · see citing works
The List of Threatening Experiences: a subset of 12 life event categories with considerable long-term contextual threat
Brugha, T. S., Bebbington, P., Tennant, C., & Hurry, J. (1985) · Psychological Medicine · doi:10.1017/s003329170002105x · Cited by 1,108 · see citing works
Social supports and serotonin transporter gene moderate depression in maltreated children
Kaufman, J., Yang, B., Douglas-Palumberi, H., Houshyar, S., Lipschitz, D. S., Krystal, J. H., & Gelernter, J. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404376101 · Cited by 801 · see citing works
Meta‐analysis of the association between a serotonin transporter promoter polymorphism (5‐HTTLPR) and anxiety‐related personality traits
Sen, S., Burmeister, M., & Ghosh, D. (2004) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20158 · Cited by 740 · see citing works
The Interaction of Stressful Life Events and a Serotonin Transporter Polymorphism in the Prediction of Episodes of Major Depression
Kendler, K. S., Kuhn, J. W., Vittum, J., Prescott, C. A., & Riley, B. P. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.5.529 · Cited by 669 · see citing works
Gene–environment interaction analysis of serotonin system markers with adolescent depression
Eley, T. C., Sugden, K., Corsico, A., Gregory, A. M., Sham, P., McGuffin, P., Plomin, R., & Craig, I. W. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001546 · Cited by 663 · see citing works
A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety.
Schinka, J. A., Busch, R. M., & Robichaux-Keene, N. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001405 · Cited by 521 · see citing works
Synaptic organization of serotonin‐immunoreactive fibers in primary visual cortex of the macaque monkey
de Lima, A. D., Bloom, F. E., & Morrison, J. H. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902740211 · Cited by 459 · see citing works
Life events, first depression onset and the serotonin transporter gene
Wilhelm, K. A., Mitchell, P. B., Niven, H., Finch, A. W., Wedgwood, L., Scimone, A., Blair, I. P., Parker, G. B., & Schofield, P. R. (2006) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.105.009522 · Cited by 309 · see citing works
The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression
Gillespie, N. A., Whitfield, J. B., WILLIAMS, B., Heath, A. C., & Martin, N. G. (2004) · Psychological Medicine · doi:10.1017/s0033291704002727 · Cited by 295 · see citing works
Mental and physical distress is modulated by a polymorphism in the 5-HT transporter gene interacting with social stressors and chronic disease burden
Grabe, H.-J., Lange, M., Wolff, B., Völzke, H., Lucht, M. J., Freyberger, H. J., John, U., & Cascorbi, I. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001555 · Cited by 279 · see citing works
Association of obesity with anxiety, depression and emotional well‐being: a community survey
Jorm, A. F., Korten, A. E., Christensen, H., Jacomb, P. A., Rodgers, B., & Parslow, R. A. (2003) · Australian and New Zealand Journal of Public Health · doi:10.1111/j.1467-842x.2003.tb00423.x · Cited by 271 · see citing works
Self-citation
Social Adversity, the Serotonin Transporter (5-HTTLPR) Polymorphism and Major Depressive Disorder
Surtees, P. G., Wainwright, N. W. J., Willis-Owen, S. A. G., Luben, R., Day, N. E., & Flint, J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.07.014 · Cited by 265 · see citing works
Does measurement instrument moderate the association between the serotonin transporter gene and anxiety-related personality traits? A meta-analysis
Munafo, M. R., Clark, T. G., & Flint, J. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001627 · Cited by 250 · see citing works
Childhood adversity in an Australian population
Rosenman, S. J., & Rodgers, B. (2004) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-004-0802-0 · Cited by 175 · see citing works
An association study of a functional polymorphism of the serotonin transporter gene with personality and psychiatric symptoms
Jorm, A. F., Henderson, A. S., Jacomb, P. A., Christensen, H. M., Korten, A. E., Rodgers, B., Tan, X., & Easteal, S. (1998) · Molecular Psychiatry · doi:10.1038/sj.mp.4000424 · Cited by 132 · see citing works
Self-citation
Association between 5-HTTLPR genotypes and persisting patterns of anxiety and alcohol use: results from a 10-year longitudinal study of adolescent mental health
Olsson, C. A., Byrnes, G. B., Lotfi-Miri, M., Collins, V., Williamson, R., Patton, C., & Anney, R. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001677 · Cited by 77 · see citing works
Association of a functional polymorphism of the serotonin transporter gene with anxiety-related temperament and behavior problems in children: a longitudinal study from infancy to the mid-teens
Jorm, A. F., Prior, M., Sanson, A. V., Smart, D., Zhang, Y., & Easteal, S. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000782 · Cited by 73 · see citing works
Self-citation
Incidence of social phobia and identification of its risk indicators: a model for prevention
Acartürk, C., Smit, F., de Graaf, R., van Straten, A., ten Have, M., & Cuijpers, P. J. (2008) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2008.01275.x · Cited by 72 · see citing works
Promise and pitfalls in the meta-analysis of genetic association studies: a response to Sen and Schinka
Munafo, M. R., Clark, T. G., & Jonathan Flint, C. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001706 · Cited by 27 · see citing works
Evaluation of multiple displacement amplification in a 5 cM STR genome-wide scan
Dickson, P. A. (2005) · Nucleic Acids Research · doi:10.1093/nar/gni126 · Cited by 19 · see citing works
Measurement scale does moderate the association between the serotonin transporter gene and trait anxiety: comments on Munafo et al
Schinka, J. A. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001708 · Cited by 18 · see citing works
5-HTTLPR and anxiety-related personality traits meta-analysis revisited: response to Munafo and colleagues
Sen, S., Burmeister, M., & Ghosh, D. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001705 · Cited by 17 · see citing works

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Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression: A Meta-analysis
Risch, N., Herrell, R., Lehner, T., Liang, K.-Y., Eaves, L., Hoh, J., Griem, A., Kovacs, M., Ott, J., & Merikangas, K. R. (2009) · JAMA · doi:10.1001/jama.2009.878 · Cited by 1,655 · see citing works
Population-based study of first onset and chronicity in major depressive disorder
Eaton, W. W., Shao, H., Nestadt, G., Lee, B. H., Bienvenu, O. J., & Zandi, P. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.5.513 · Cited by 612 · see citing works
The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update
Uher, R., & McGuffin, P. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.123 · Cited by 424 · see citing works
Gene–environment interactions: early life stress and risk for depressive and anxiety disorders
Nugent, N. R., Tyrka, A. R., Carpenter, L. L., & Price, L. H. (2011) · Psychopharmacology · doi:10.1007/s00213-010-2151-x · Cited by 269 · see citing works
“All but one (Chorbov et al. 2007) of the studies reporting GxE effects with increased risk conferred by l/l′ included socioeconomic status in their definition of ELS (Chipman et al. 2007; Laucht et al. 2009; Ritchie et al. 2009; Sjoberg et al. 2006).”
BackgroundMethodInfluential
Interactive Effect of Stressful Life Events and the Serotonin Transporter 5-HTTLPR Genotype on Posttraumatic Stress Disorder Diagnosis in 2 Independent Populations
Xie, P., Kranzler, H. R., Poling, J., Stein, M. B., Anton, R. F., Brady, K., Weiss, R. D., Farrer, L., & Gelernter, J. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.153 · Cited by 264 · see citing works
Early adversity and adult health outcomes
Taylor, S. E., Way, B. M., & Seeman, T. E. (2011) · Development and Psychopathology · doi:10.1017/s0954579411000411 · Cited by 235 · see citing works
How does the social environment ‘get into the mind’? Epigenetics at the intersection of social and psychiatric epidemiology
Toyokawa, S., Uddin, M., Koenen, K. C., & Galea, S. (2011) · Social Science & Medicine · doi:10.1016/j.socscimed.2011.09.036 · Cited by 219 · see citing works
What Can We Learn about Resilience from Large-Scale Longitudinal Studies?
Werner, E. Ε. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3661-4_6 · Cited by 222 · see citing works
Association of the5-HTTLPRgenotype and unipolar depression: a meta-analysis
Clarke, H. F., Flint, J., Attwood, A. S., & Munafo, M. R. (2010) · Psychological Medicine · doi:10.1017/s0033291710000516 · Cited by 177 · see citing works
Gene-Environment Interactions in Depression Research
Monroe, S. M., & Reid, M. W. (2008) · Psychological Science · doi:10.1111/j.1467-9280.2008.02181.x · Cited by 166 · see citing works
An update on the interaction between the serotonin transporter promoter variant (5-HTTLPR), stress and depression, plus an exploration of non-confirming findings
Sharpley, C. F., Palanisamy, S. K. A., Glyde, N. S., Dillingham, P. W., & Agnew, L. L. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.030 · Cited by 154 · see citing works
Candidate Genes and Political Behavior
Charney, E., & ENGLISH, W. (2012) · American Political Science Review · doi:10.1017/s0003055411000554 · Cited by 146 · see citing works
The serotonin transporter polymorphism (5-HTTLPR): allelic variation and links with depressive symptoms
Goldman, N., Glei, D. A., Lin, Y.-H., & Weinstein, M. (2010) · Depression and Anxiety · doi:10.1002/da.20660 · Cited by 144 · see citing works
Risk for Depression During Interferon-Alpha Treatment Is Affected by the Serotonin Transporter Polymorphism
Lotrich, F. E., Ferrell, R. E., Rabinovitz, M., & Pollock, B. G. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.009 · Cited by 136 · see citing works
From nature versus nurture, via nature and nurture, to gene × environment interaction in mental disorders
Wermter, A., Laucht, M., SCHIMMELMANN, B. G., Banaschewski, T., Sonuga-Barke, E. J. S., Rietschel, M., & Becker, K. (2009) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-009-0082-z · Cited by 132 · see citing works
Interaction between the 5-HTTLPR serotonin transporter polymorphism and environmental adversity for mood and anxiety psychopathology: evidence from a high-risk community sample of young adults
Laucht, M., Treutlein, J., Blomeyer, D., Buchmann, A. F., Schmid, B., Becker, K., Zimmermann, U. S., Schmidt, M. H., Esser, G., Rietschel, M., et al. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009875 · Cited by 125 · see citing works
Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression
RISCH, N. J., Herrell, R. K., Lehner, T., Liang, K., & Merikangas, K. R. (2015) · Cited by 122 · see citing works
Serotonin Transporter Gene Moderates the Development of Emotional Problems Among Children Following Bullying Victimization
Sugden, K., Arseneault, L., Harrington, H., Moffitt, T. E., Williams, B. S., & Caspi, A. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2010.01.024 · Cited by 115 · see citing works
Sleep quality and diurnal preference in a sample of young adults: Associations with 5HTTLPR, PER3, and CLOCK 3111
Barclay, N. L., Eley, T. C., Mill, J. S., Wong, C. C. Y., Zavos, H. M. S., Archer, S. N., & Gregory, A. M. (2011) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31210 · Cited by 113 · see citing works
Lifestyle factors and adolescent depressive symptomatology: Associations and effect sizes of diet, physical activity and sedentary behaviour
Hayward, J., Jacka, F. N., Skouteris, H., Millar, L., Strugnell, C., Swinburn, B. A., & Allender, S. E. (2016) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867416671596 · Cited by 111 · see citing works
Research Review: Gene–environment interaction research in youth depression – a systematic review with recommendations for future research
Dunn, E. C., Uddin, M., Subramanian, S. V., Smoller, J. W., Galea, S., & Koenen, K. C. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2011.02466.x · Cited by 104 · see citing works
New Evidence for the Association of the Serotonin Transporter Gene (SLC6A4) Haplotypes, Threatening Life Events, and Depressive Phenotype
Lazáry, J., Lazáry, Á., Gonda, X., Benkő, A., Molnár, E., Juhász, G., & Bagdy, G. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.03.030 · Cited by 99 · see citing works
Chronic and acute stress, gender, and serotonin transporter gene–environment interactions predicting depression symptoms in youth
Hammen, C. L., Brennan, P. A., Keenan‐Miller, D., Hazel, N. A., & Najman, J. M. (2009) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2009.02177.x · Cited by 98 · see citing works
Genetics of nicotine dependence and pharmacotherapy
Lessov‐Schlaggar, C. N., Pergadia, M. L., Khroyan, T. V., & Swan, G. E. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.08.018 · Cited by 95 · see citing works
Interaction between genetic polymorphisms and stressful life events in first episode depression
Bukh, J. D., Bock, C., Vinberg, M., Werge, T. M., Gether, U., & Kessing, L. V. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.02.023 · Cited by 92 · see citing works
The combined effects of the 5-HTTLPR and 5-HTR1A genes modulates the relationship between negative life events and major depressive disorder in a Chinese population
Zhang, K., Xu, Q., Xu, Y. J., Yang, H., Luo, J., Sun, Y., Sun, N., Wang, S., & Shen, Y. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.07.012 · Cited by 91 · see citing works
The Serotonin Transporter Promoter Variant (5-HTTLPR), Stress, and Depression Meta-analysis Revisited: Evidence of Genetic Moderation
Karg, K., Burmeister, M., Shedden, K., & Sen, S. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.189 · Cited by 87 · see citing works
Advance in Stress for Depressive Disorder
Ding, Y., & Dai, J. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9271-0_8 · Cited by 82 · see citing works
Impact of the Interaction Between the 5HTTLPR Polymorphism and Maltreatment on Adolescent Depression. A Population-Based Study
Åslund, C., Leppert, J., Comasco, E., Nordquist, N., Oreland, L., & Nilsson, K. W. (2009) · Behavior Genetics · doi:10.1007/s10519-009-9285-9 · Cited by 75 · see citing works
The Genetics of Mood Disorders
Lau, J. Y. F., & Eley, T. C. (2009) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.121208.131308 · Cited by 68 · see citing works
Serotonin transporter gene polymorphism (5-HTTLPR), environmental conditions, and developing negative emotionality and fear in early childhood
Pauli‐Pott, U., Friedl, S., Hinney, A., & Hebebrand, J. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-008-0171-z · Cited by 63 · see citing works
The Heritability of Postpartum Depression
Corwin, E. J., Kohen, R., Jarrett, M. E., & Stafford, B. (2010) · Biological Research For Nursing · doi:10.1177/1099800410362112 · Cited by 62 · see citing works
Vulnerability to depression: A moderated mediation model of the roles of child maltreatment, peer victimization, and serotonin transporter linked polymorphic region genetic variation among children from low socioeconomic status backgrounds
Inscoe, A. B., Cicchetti, D., Rogosch, F. A., Oshri, A., & Crick, N. R. (2013) · Development and Psychopathology · doi:10.1017/s0954579413000047 · Cited by 60 · see citing works
Reduced functional connectivity of fronto-parietal sustained attention networks in severe childhood abuse
Hart, H. C., Lim, L. L., Mehta, M. A., Chatzieffraimidou, A., Curtis, C. J. C., Xu, X., Breen, G. D., Simmons, A., Mirza, K., & Rubia, K. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188744 · Cited by 58 · see citing works
Emotion Regulation Moderates the Risk Associated with the 5-HTT Gene and Stress in Children
Ford, B. Q., Mauss, I. B., Troy, A. S., Smolen, A., & Hankin, B. (2014) · Emotion · doi:10.1037/a0036835 · Cited by 56 · see citing works
Interaction between serotonin transporter polymorphism (5-HTTLPR) and stressful life events in adolescents' trajectories of anxious/depressed symptoms.
Petersen, I. T., Bates, J. E., Goodnight, J. A., Dodge, K. A., Lansford, J. E., Pettit, G. S., Latendresse, S. J., & Dick, D. M. (2012) · Developmental Psychology · doi:10.1037/a0027471 · Cited by 55 · see citing works
Gene × Environment effects of serotonin transporter, dopamine receptor D4, and monoamine oxidase A genes with contextual and parenting risk factors on symptoms of oppositional defiant disorder, anxiety, and depression in a community sample of 4-year-old children
Lavigne, J. V., Herzing, L. B. K., Cook, E. H., LeBailly, S. A., Gouze, K. R., Hopkins, J., & Bryant, F. B. (2013) · Development and Psychopathology · doi:10.1017/s0954579412001241 · Cited by 53 · see citing works
Interaction of chronic stress with serotonin transporter and catechol-O -methyltransferase polymorphisms in predicting youth depression
Conway, C., Hammen, C. L., Brennan, P. A., Lind, P. A., & Najman, J. M. (2010) · Depression and Anxiety · doi:10.1002/da.20715 · Cited by 51 · see citing works
A protective genetic variant for adverse environments? The role of childhood traumas and serotonin transporter gene on resilience and depressive severity in a high-risk population
Carli, V., Mandelli, L., Zaninotto, L., Roy, A., Recchia, L., Stoppia, L., Gatta, V., Sarchiapone, M., & Serretti, A. (2011) · European Psychiatry · doi:10.1016/j.eurpsy.2011.04.008 · Cited by 50 · see citing works
Cultural consonance, a 5HT2A receptor polymorphism, and depressive symptoms: A longitudinal study of gene × culture interaction in urban Brazil
Dressler, W. W., Balieiro, M. C., Ribeiro, R. P. P., & dos Santos, J. E. (2008) · American Journal of Human Biology · doi:10.1002/ajhb.20823 · Cited by 50 · see citing works
Current developments and controversies: does the serotonin transporter gene-linked polymorphic region (5-httlpr) modulate the association between stress and depression?
Wankerl, M., Wüst, S., & Otte, C. (2010) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32833f0e3a · Cited by 49 · see citing works
The Australian Temperament Project: The First 30 Years
Vassallo, S., & Sanson, A. V. (2013) · PsycEXTRA Dataset · doi:10.1037/e567282013-001 · Cited by 46 · see citing works
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Das, D., Cherbuin, N., Tan, X., Anstey, K. J., & Easteal, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020177 · Cited by 42 · see citing works
Self-citation
Protocol for a collaborative meta-analysis of 5-HTTLPR, stress, and depression
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Gender differences in the genetic and environmental determinants of adolescent depression
Uddin, M., Koenen, K. C., Santos, R. D. L., Ware, E. B., Aiello, A. E., & Galea, S. (2010) · Depression and Anxiety · doi:10.1002/da.20692 · Cited by 40 · see citing works
Depressive symptomatology, weight status and obesogenic risk among Australian adolescents: a prospective cohort study
Hoare, E., Millar, L., Fuller‐Tyszkiewicz, M., Skouteris, H., Nichols, M. S., Malakellis, M., Swinburn, B. A., & Allender, S. E. (2016) · BMJ Open · doi:10.1136/bmjopen-2015-010072 · Cited by 40 · see citing works
Associations between obesogenic risk and depressive symptomatology in Australian adolescents: a cross-sectional study
Hoare, E., Millar, L., Fuller‐Tyszkiewicz, M., Skouteris, H., Nichols, M. S., Jacka, F. N., Swinburn, B. A., Chikwendu, C., & Allender, S. E. (2014) · Journal of Epidemiology & Community Health · doi:10.1136/jech-2013-203562 · Cited by 35 · see citing works
Time moderates the interplay between 5-HTTLPR and stress on depression risk: gene x environment interaction as a dynamic process
Colli, C. D., Borgi, M., Poggini, S., Chiarotti, F., Cirulli, F., Penninx, B. W. J. H., Benedetti, F., Vai, B., & Branchi, I. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02035-4 · Cited by 34 · see citing works
Serotonin transporter gene moderates associations between mood, memory and hippocampal volume
Price, J. S., Strong, J. A., Eliassen, J. C., McQueeny, T. M., Miller, M. M., Padula, C. B., Shear, P. K., & Lisdahl, K. M. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.11.013 · Cited by 33 · see citing works
Negative social acts and pain: evidence of a workplace bullying and 5-HTT genotype interaction
Jacobsen, D. P., Nielsen, M. B., Einarsen, S. V., & Gjerstad, J. (2018) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.3704 · Cited by 32 · see citing works
Interaction between a serotonin transporter gene promoter region polymorphism and stress predicts depressive symptoms in Chinese adolescents: a multi-wave longitudinal study
Ming, Q., Zhang, Y., Chai, Q., Chen, H.-Y., Hou, C.-J., Wang, M., Wang, Y.-P., Cai, L., Zhu, X., Yi, J., et al. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-142 · Cited by 28 · see citing works
Effect of gene, environment and maternal depressive symptoms on pre-adolescence behavior problems – a longitudinal study
Agnafors, S., Comasco, E., Bladh, M. K., Sydsjö, G., deKeyser, L., Oreland, L., & Svedin, C. G. (2013) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/1753-2000-7-10 · Cited by 27 · see citing works
Altered Functional Connectivity of Fronto-Cingulo-Striatal Circuits during Error Monitoring in Adolescents with a History of Childhood Abuse
Hart, H. C., Lim, L. L., Mehta, M. A., Curtis, C. J. C., Xu, X., Breen, G. D., Simmons, A., Mirza, K., & Rubia, K. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00007 · Cited by 27 · see citing works
Depression and serotonin transporter (5-HTTLPR) polymorphism in breast cancer patients
Grassi, L. G., Rossi, E. G., Cobianchi, M., Aguiari, L., Capozzo, M. A., Martinis, E., Nanni, M. G., LELLI, G., Schillani, G., Biancosino, B., et al. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.12.022 · Cited by 25 · see citing works
Genetik depressiver Störungen
Schulte‐Körne, G., & Allgaier, A. (2008) · Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie · doi:10.1024/1422-4917.36.1.27 · Cited by 24 · see citing works
Do prostate cancer patients suffer more from depressed mood or anhedonia?
Sharpley, C. F., Bitsika, V., & Christie, D. (2012) · Psycho-Oncology · doi:10.1002/pon.3203 · Cited by 18 · see citing works
Effects of Recent Stress and Variation in the Serotonin Transporter Polymorphism (5-HTTLPR) on Depressive Symptoms: A Repeated-Measures Study of Adults Age 50 and Older
Arpawong, T. E., Lee, J., Phillips, D. F., Crimmins, E. M., Levine, M. E., & Prescott, C. A. (2015) · Behavior Genetics · doi:10.1007/s10519-015-9740-8 · Cited by 16 · see citing works
Alcohol Dependence and Genetic Variability in the Serotonin Pathway among Currently and Formerly Alcohol-Dependent Males
Ilješ, A. P., Kastelic, M., Porcelli, S., Serretti, A., Dolžan, V., & Plesničar, B. K. (2015) · Neuropsychobiology · doi:10.1159/000437432 · Cited by 16 · see citing works
Depression polygenic scores are associated with major depressive disorder diagnosis and depressive episode in Mexican adolescents
Rabinowitz, J. A., Campos, A. I., Benjet, C. L., Su, J., Kauffer, L. R. M., Méndez, E., Martínez-Levy, G. A., Cruz-Fuentes, C. S., & Rentería, M. E. (2020) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2020.100028 · Cited by 12 · see citing works
Does Desire to Pursue Pleasurable Activities Matter? The Impact of Pretransplantation Anhedonia on Quality of Life and Fatigue in Hematopoietic Stem Cell Transplantation
Amonoo, H. L., Fenech, A. L., Greer, J. A., Temel, J. S., Huffman, J. C., & El-Jawahri, A. R. (2020) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2020.04.014 · Cited by 10 · see citing works
Suppression mediates the effect of 5‐ HTTLPR by stress interaction on depression
Knyazev, G. G., Базовкина, Д. В., Savostyanov, A. N., Naumenko, V. S., Kuznetsova, V. B., & Proshina, E. A. (2017) · Scandinavian Journal of Psychology · doi:10.1111/sjop.12389 · Cited by 10 · see citing works
GOLDSMITHS Research Online
de Fockert, J. W., Rees, G. E., Frith, C., & Lavie, N. (2007) · Cited by 10 · see citing works
Effect of 5-HTTLPR on current source density, connectivity, and topological properties of resting state EEG networks
Proshina, E. A., Savostyanov, A. N., Bocharov, A. V., & Knyazev, G. G. (2018) · Brain Research · doi:10.1016/j.brainres.2018.06.018 · Cited by 8 · see citing works
G × E interaction and neurodevelopment II. Focus on adversities in paediatric depression: the moderating role of serotonin transporter
Bellani, M., Nobile, M., Bianchi, V., van Os, J., & Brambilla, P. (2012) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796012000625 · Cited by 6 · see citing works
Resting State Networks Mediate the Effect of Genotype by Environment Interaction on Mental Health
Knyazev, G. G., Savostyanov, A. N., Bocharov, A. V., Базовкина, Д. В., & Proshina, E. A. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.11.010 · Cited by 6 · see citing works
Gender differences in the genetic and environmental determinants of adolescent depression
Uddin, M., Koenen, K. C., Santos, R. D. L., Bakshis, E., Aiello, A. E., & Galea, S. (2010) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2010.06.046 · Cited by 4 · see citing works
Serotonin Transporter Polymorphism in Relation to Depression
Peitl, V., Karlović, D., Štefanović, M., & Vrkić, N. (2015) · Hrčak Portal of scientific journals of Croatia (University Computing Centre) · Cited by 4 · see citing works
Developmental Antecedents of Adult Macaque Neurogenesis: Early-Life Adversity, 5-HTTLPR Polymorphisms, and Adolescent Hippocampal Volume
Schoenfeld, E. M., Gupta, N. K., Syed, S. A., Rozenboym, A. V., Fulton, S. L., Jackowski, A. P., Perera, T. D., & Coplan, J. D. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.02.052 · Cited by 4 · see citing works
From syndromes to symptoms: Advancing our understanding of mental disorders
Clack, S. (2020) · doi:10.26686/wgtn.17151110.v1 · Cited by 3 · see citing works
Depression Persistence and Serotonin Transporter Genotype in Adolescents under Usual Care Conditions
Kohen, R., Myaing, M. T., Richards, J. A., Zhou, C., McCauley, E., Katon, W. J., & Richardson, L. P. (2013) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2011.0137 · Cited by 2 · see citing works
The Trilogy of GxE: Conceptualization, Operationalization, and Application
Grigorenko, E., Bick, J., Campbell, D., Lewine, G., Abrams, J., Nguyen, V., & Chang, J. T. (2016) · Wiley eBooks · doi:10.1002/9781119125556.devpsy208 · Cited by 2 · see citing works
Childhood Maltreatment and County-Level Deprivation Jointly Modify the Effect of Serotonin Transporter Promoter Genotype on Depressive Symptoms in Adolescent Girls
Uddin, M., Ware, E. B., & Santos, R. D. L. (2012) · InTech eBooks · doi:10.5772/31084 · Cited by 1 · see citing works
Genetics and Genomics of Posttraumatic Stress Disorder
Uddin, M., Amstadter, A. B., Nugent, N. R., & Koenen, K. C. (2012) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780195399066.013.0011 · Cited by 1 · see citing works
Internalizing Psychopathology across the Life Course: From Genes and Environment to Gene-Environment Interaction
Thompson, E. J., Kazantseva, A., & Gaysina, D. (2017) · Psychopathology Review · doi:10.5127/pr.038415
Genetic and environmental influences on sleep quality : quantitative and molecular genetic approaches to an understanding of individual differences
Barclay, N. L. (2011) · Goldsmiths (University of London)
A Biopsychosocial and Long Term Perspective on Child Behavioral Problems : Impact of Risk and Resilience
Agnafors, S. (2016) · Linköping University medical dissertations · doi:10.3384/diss.diva-124209
Critical Review of Gene-Environment Interactions in Psychiatry: Evidence Consistent with the Possibility of Publication Bias, Low Power, Multiple Testing, and Type I Errors in the Literature
Duncan, L. E. (2011) · CU Scholar (University of Colorado Boulder)
Dating Violence Victimization and Substance Use: Do Genes Play a Role?
Yohros, A. (2017) · Journal of International Crisis and Risk Communication Research
Depression Risk in Young Adults: Could a Dopamine Receptor Gene Moderate the Role of Childhood Adversities?
Landers, C. (2011) · ANU Undergraduate Research Journal · doi:10.22459/aurj.03.2011.06
Studies of the 5-HTTLPR Serotonin Transporter Polymorphism (literature review)
Proshina, E., Bocharov, A., Savostyanov, A., & Knyazev, G. (2022) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-022-01314-3

Interaction between the 5-HTTLPR serotonin transporter polymorphism and environmental adversity for mood and anxiety psychopathology: evidence from a high-risk community sample of young adults
Laucht, M., Treutlein, J., Blomeyer, D., Buchmann, A. F., Schmid, B., Becker, K., Zimmermann, U. S., Schmidt, M. H., Esser, G., Rietschel, M., et al. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009875 · Cited by 125 · see citing works
Serotonin transporter‐linked polymorphic region (5‐ HTTLPR ) genotype and stressful life events interact to predict preschool‐onset depression: a replication and developmental extension
Bogdan, R., Arpana Agrawal, A., Gaffrey, M. S., Tillman, R., & Luby, J. L. (2013) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12142 · Cited by 47 · see citing works
Early Family Environment, Current Adversity, the Serotonin Transporter Promoter Polymorphism, and Depressive Symptomatology
Taylor, S. E., Way, B. M., Welch, W. T., Hilmert, C. J., Lehman, B. J., & Eisenberger, N. I. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.019 · Cited by 432 · see citing works
No interaction between serotonin transporter gene (5-HTTLPR) polymorphism and adversity on depression among Japanese children and adolescents
Tomoda, A., Nishitani, S., Matsuura, N., Fujisawa, T. X., Kawatani, J., Toyohisa, D., Ono, M., & Shinohara, K. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-134 · Cited by 9 · see citing works
Interaction between serotonin transporter polymorphism (5-HTTLPR) and stressful life events in adolescents' trajectories of anxious/depressed symptoms.
Petersen, I. T., Bates, J. E., Goodnight, J. A., Dodge, K. A., Lansford, J. E., Pettit, G. S., Latendresse, S. J., & Dick, D. M. (2012) · Developmental Psychology · doi:10.1037/a0027471 · Cited by 55 · see citing works

Authors: Chipman, P., Jorm, A. F., Prior, M., Sanson, A., Smart, D., Tan, X., & Easteal, S.
Affiliations: Australian National University (AU)
The University of Melbourne (AU)
Australian Institute of Family Studies (AU)
Corresponding author: Chipman, P.
ORCID: Jorm, A.F.
Sanson, A.
Smart, D.
Easteal, S.
Venue: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Publisher: Wiley
Published: 2007-04-20
Volume: 144B
Issue: 4
Pages: 561-565
ISSN: 1552-4841 (ISSN-L)
1552-485X
DOI: 10.1002/ajmg.b.30480
OpenAlex: W2145430042
Cited by: 81
References: 30
Citations by year: 2022: 2 · 2021: 1 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 4 · 2014: 3 · 2013: 6 · 2012: 8
FWCI: 3.70
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: American Journal of Medical Genetics Part B Neuropsychiatric Genetics (publishedVersion)
PubMed (publishedVersion)
ANU Open Research (Australian National University) (submittedVersion)
Funders: Australian Research Council
National Health and Medical Research Council
National Medical Research Council
Health and Medical Research Fund
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Keywords: serotonin transporter gene, 5-HTTLPR polymorphism, gene-environment interaction, childhood adversity, life events, depressive symptoms, adolescents, young adults, family adversity, genetic risk
MeSH terms: Adolescent, Adult, Data Collection, Depression, Female, Genotype, Humans, Life Change Events, Male, Polymorphism, Genetic, Sex Characteristics, Logistic Models, Serotonin Plasma Membrane Transport Proteins

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No interaction between the serotonin transporter polymorphism (5‐HTTLPR) and childhood adversity or recent stressful life events on symptoms of depression: Results from two community surveys

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