Cited by 112Child Abuse and TraumaSchizophrenia research and treatmentStress Responses and Cortisol

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Childhood maltreatment is associated with increased body mass index and increased C-reactive protein levels in first-episode psychosis patients

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Hepgul, N., Pariante, C. M., Dipasquale, S., DiForti, M., Taylor, H., Marques, T. R., Morgan, C., Dazzan, P., Murray, R. M., Mondelli, V.·2012·Psychological Medicine

DOI 10.1017/s0033291711002947PMC PMC4081598

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Abstract

Background: The high incidence of the metabolic syndrome in patients with psychosis is mainly attributed to antipsychotic treatment. However, it is also possible that psychological stress plays a role, inducing a chronic inflammatory process that may predispose to the development of metabolic abnormalities. We investigated the association between childhood maltreatment and inflammatory and metabolic biomarkers in subjects with first-episode psychosis and healthy controls. Method: Body mass index (BMI), weight and waist circumference were measured in 95 first-episode psychosis patients and 97 healthy controls. Inflammatory and metabolic markers were measured in a subsample of 28 patients and 45 controls. In all the subjects we collected information on childhood maltreatment and recent stressors. Results: Patients with childhood maltreatment had higher BMI [25.0 (s.e.=0.6) kg/m 2] and C-reactive protein (CRP) levels [1.1 (s.e.=0.6) mg/dl] when compared with healthy controls [23.4 (s.e.=0.4) kg/m 2,p=0.030 and 0.2 (s.e.=0.1) mg/dl,p=0.009, respectively]. In contrast, patients without childhood maltreatment were not significantly different from healthy controls for either BMI [24.7 (s.e.=0.6) kg/m 2,p=0.07] or CRP levels [0.5 (s.e.=0.2) mg/dl,p=0.25]. After controlling for the effect of BMI, the difference in CRP levels across the three groups remained significant (F2,58=3.6,p=0.035), suggesting that the increase in inflammation was not driven by an increase in adipose tissue. Conclusions: Childhood maltreatment is associated with higher BMI, and increased CRP levels, in patients with a first-episode psychosis. Further studies need to confirm the mechanisms underlying the putative causal relationship between childhood maltreatment and higher BMI, and whether this is indeed mediated by increased inflammation.

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Inflammation and metabolic disorders
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Authors: Hepgul, N., Pariante, C. M., Dipasquale, S., DiForti, M., Taylor, H., Marques, T. R., Morgan, C., Dazzan, P., Murray, R. M., & Mondelli, V.
Affiliations: King's College London (GB)
Corresponding author: Mondelli, V.
ORCID: Hepgul, N.
Pariante, C. M.
Taylor, H.
Marques, T. R.
Morgan, C.
Dazzan, P.
Murray, R. M.
Mondelli, V.
Venue: Psychological Medicine
Publisher: Cambridge University Press (CUP)
Published: 2012-01-20
Volume: 42
Issue: 9
Pages: 1893-1901
ISSN: 0033-2917 (ISSN-L)
1469-8978
DOI: 10.1017/s0033291711002947
PMC: PMC4081598
OpenAlex: W2168638813
Semantic Scholar: 194871c8c144797db553c36f6948a40d07d4c771
Cited by: 112
References: 44
Citations by year: 2026: 1 · 2025: 4 · 2024: 3 · 2023: 12 · 2022: 5 · 2021: 10 · 2020: 12 · 2019: 8 · 2018: 11 · 2017: 10 · 2016: 7 · 2015: 15 · 2014: 4 · 2013: 6 · 2012: 4
FWCI: 10.55
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.cambridge.org/core/terms (unspecified)
Locations: Psychological Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Research Portal (King's College London) (submittedVersion)
Funders: Wellcome Trust (WT087417, 087417)
National Institute for Health and Care Research (CL-2008-17-005)
Academy of Medical Sciences (AMS-SGCL5-Mondelli)
Medical Research Council (MR/J002739/1)
Topics: Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: child abuse, first-episode psychosis, body mass index, C-reactive protein, inflammation, metabolic syndrome, psychological stress, adiposity, waist circumference, antipsychotic-induced metabolic effects
MeSH terms: Adipose Tissue, Adolescent, Adult, C-Reactive Protein, Female, Humans, Inflammation, Male, Psychotic Disorders, Antipsychotic Agents, Body Mass Index, Case-Control Studies, Metabolic Syndrome, Adult Survivors of Child Abuse, Waist Circumference

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Childhood maltreatment is associated with increased body mass index and increased C-reactive protein levels in first-episode psychosis patients

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