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Stress-related anhedonia is associated with ventral striatum reactivity to reward and transdiagnostic psychiatric symptomatology
Open accessAbstract
BACKGROUND: Early life stress (ELS) is consistently associated with increased risk for subsequent psychopathology. Individual differences in neural response to reward may confer vulnerability to stress-related psychopathology. Using data from the ongoing Duke Neurogenetics Study, the present study examined whether reward-related ventral striatum (VS) reactivity moderates the relationship between retrospectively reported ELS and anhedonic symptomatology. We further assessed whether individual differences in reward-related VS reactivity were associated with other depressive symptoms and problematic alcohol use via stress-related anhedonic symptoms and substance use-associated coping. METHOD: Blood oxygen level-dependent functional magnetic resonance imaging (fMRI) was collected while participants (n = 906) completed a card-guessing task, which robustly elicits VS reactivity. ELS, anhedonic symptoms, other depressive symptoms, coping behavior, and alcohol use behavior were assessed with self-report questionnaires. Linear regressions were run to examine whether VS reactivity moderated the relationship between ELS and anhedonic symptoms. Structural equation models examined whether this moderation was indirectly associated with other depression symptoms and problematic alcohol use through its association with anhedonia. RESULTS: Analyses of data from 820 participants passing quality control procedures revealed that the VS × ELS interaction was associated with anhedonic symptoms (p = 0.011). Moreover, structural equation models indirectly linked this interaction to non-anhedonic depression symptoms and problematic alcohol use through anhedonic symptoms and substance-related coping. CONCLUSIONS: These findings suggest that reduced VS reactivity to reward is associated with increased risk for anhedonia in individuals exposed to ELS. Such stress-related anhedonia is further associated with other depressive symptoms and problematic alcohol use through substance-related coping.
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“in many of the human studies reviewed, decreased activation in regions of the basal ganglia to the anticipation or receipt of reward was not only associated with depressive symptoms (Dillon et al., 2009; Goff et al., 2013), but often found to mediate the relationship between ELS and depression (Corral-Frías et al., 2015; Hanson et al., 2015).”
From The effects of early life stress on reward processing (2018) · cites this paper as Corral-Frías et al., 2015
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“Diminished activity in the ventral striatum in response to anticipation of monetary reward has been associated with anhedonia in adolescents, and ventral striatum activity in response to reward may be moderated by exposure to early life stress (192).”
From A transdiagnostic perspective on social anhedonia (2019) · cites this paper as [192]
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Cites
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267
(2013) · Cited by 44,563
(1998) · The Journal of Clinical Psychiatry · Cited by 19,139
SAUNDERS, J. B., AASLAND, O. G., BABOR, T. F., DE LA FUENTE, J. R., & GRANT, M. (1993) · Addiction · doi:10.1111/j.1360-0443.1993.tb02093.x · Cited by 13,597 · cited 1×
“…form (MASQ-SF; Watson & Clark, 1991); the Positive Affect subscale of the Center for Epidemiological Studies – Depression Scale (CES-D; Radloff, 1977) the brief COPE Inventory substance use subscale Carver (1997); and the Alcohol Use Disorders Identification Test (AUDIT; Saunders et al. 1993).”
Method(1998) · PubMed · Cited by 10,216
Schermelleh-Engel, K., Moosbrugger, H., & Müller, H. (2003) · Department of Psychology - University of Koblenz-Landau · doi:10.23668/psycharchives.12784 · Cited by 8,975
You want to measure coping but your protocol’ too long: Consider the brief cope
Carver, C. S. (1997) · International Journal of Behavioral Medicine · doi:10.1207/s15327558ijbm0401_6 · Cited by 7,361
A Beginner's Guide to Structural Equation Modeling: Fourth Edition
Schumacker, R. E., & Lomax, R. G. (2015) · doi:10.4324/9781315749105 · Cited by 6,604
Development and validation of a brief screening version of the Childhood Trauma Questionnaire
Bernstein, D. P., Stein, J. A., Newcomb, M. D., Walker, E., Pogge, D., Ahluvalia, T., Stokes, J., Handelsman, L., Medrano, M., Desmond, D., et al. (2003) · Child Abuse & Neglect · doi:10.1016/s0145-2134(02)00541-0 · Cited by 6,419
A Beginner's Guide to Structural Equation Modeling
Schumacker, R. E., & Lomax, R. G. (2004) · doi:10.4324/9781410610904 · Cited by 6,235
Research works printed but not linked: 3
- First, 1996, Structured Clinical Interview for DSM-IV Axis I Disorders, Research Version, non-patient edition.
- 10.1176/ajp.2006.163.10.1784 · DOI · Paper page
- 10.1037/0021-843X.104.1.15 · DOI
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Metadata
- Authors
- Corral-Frías, N. S., Nikolova, Y. S., Michalski, L. J., Baranger, D. A. A., Hariri, A. R., & Bogdan, R.
- Affiliations
- Washington University in St. Louis (US)
- Duke University (US)
- Corresponding author
- Corral-Frías, N. S.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2015-04-08
- Volume
- 45
- Issue
- 12
- Pages
- 2605-2617
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- PMC
- PMC4700837
- OpenAlex
- W2113504879
- Cited by
- 132
- References
- 95
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 8 · 2023: 10 · 2022: 17 · 2021: 15 · 2020: 24 · 2019: 12 · 2018: 8 · 2017: 10 · 2016: 12 · 2015: 3
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Digital Commons@Becker (Washington University School of Medicine) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- National Institute on Aging (R01AG045231, AG045231)
- National Institute of Mental Health (MH014677, T32MH014677)
- National Institute on Drug Abuse (MH014677, R01DA033369, DA031579, DA033369, R01DA031579)
- National Institute of General Medical Sciences (T32GM008151, T32GM081739)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- early life stress, anhedonia, ventral striatum, reward processing, depression, alcohol abuse, substance use coping, transdiagnostic symptoms, moderating effect
- MeSH terms
- Adaptation, Psychological, Adolescent, Adult, Alcohol Drinking, Depression, Female, Humans, Magnetic Resonance Imaging, Male, North Carolina, Psychological Tests, Reward, Stress, Psychological, Students, Universities, Linear Models, Sex Distribution, Young Adult, Anhedonia, Ventral Striatum
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