Cited by 132Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesStress Responses and Cortisol

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Stress-related anhedonia is associated with ventral striatum reactivity to reward and transdiagnostic psychiatric symptomatology

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Corral-Frías, N. S., Nikolova, Y. S., Michalski, L.J., Baranger, D. A. A., Hariri, A. R., Bogdan, R.·2015·Psychological Medicine

DOI 10.1017/s0033291715000525PMC PMC4700837

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Abstract

BACKGROUND: Early life stress (ELS) is consistently associated with increased risk for subsequent psychopathology. Individual differences in neural response to reward may confer vulnerability to stress-related psychopathology. Using data from the ongoing Duke Neurogenetics Study, the present study examined whether reward-related ventral striatum (VS) reactivity moderates the relationship between retrospectively reported ELS and anhedonic symptomatology. We further assessed whether individual differences in reward-related VS reactivity were associated with other depressive symptoms and problematic alcohol use via stress-related anhedonic symptoms and substance use-associated coping. METHOD: Blood oxygen level-dependent functional magnetic resonance imaging (fMRI) was collected while participants (n = 906) completed a card-guessing task, which robustly elicits VS reactivity. ELS, anhedonic symptoms, other depressive symptoms, coping behavior, and alcohol use behavior were assessed with self-report questionnaires. Linear regressions were run to examine whether VS reactivity moderated the relationship between ELS and anhedonic symptoms. Structural equation models examined whether this moderation was indirectly associated with other depression symptoms and problematic alcohol use through its association with anhedonia. RESULTS: Analyses of data from 820 participants passing quality control procedures revealed that the VS × ELS interaction was associated with anhedonic symptoms (p = 0.011). Moreover, structural equation models indirectly linked this interaction to non-anhedonic depression symptoms and problematic alcohol use through anhedonic symptoms and substance-related coping. CONCLUSIONS: These findings suggest that reduced VS reactivity to reward is associated with increased risk for anhedonia in individuals exposed to ELS. Such stress-related anhedonia is further associated with other depressive symptoms and problematic alcohol use through substance-related coping.

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Authors: Corral-Frías, N. S., Nikolova, Y. S., Michalski, L. J., Baranger, D. A. A., Hariri, A. R., & Bogdan, R.
Affiliations: Washington University in St. Louis (US)
Duke University (US)
Corresponding author: Corral-Frías, N. S.
ORCID: Corral-Frías, N. S.
Nikolova, Y. S.
Michalski, L.J.
Baranger, D. A. A.
Hariri, A. R.
Bogdan, R.
Venue: Psychological Medicine
Publisher: Cambridge University Press (CUP)
Published: 2015-04-08
Volume: 45
Issue: 12
Pages: 2605-2617
ISSN: 0033-2917 (ISSN-L)
1469-8978
DOI: 10.1017/s0033291715000525
PMC: PMC4700837
OpenAlex: W2113504879
Cited by: 132
References: 95
Citations by year: 2026: 6 · 2025: 7 · 2024: 8 · 2023: 10 · 2022: 17 · 2021: 15 · 2020: 24 · 2019: 12 · 2018: 8 · 2017: 10 · 2016: 12 · 2015: 3
FWCI: 5.11
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.cambridge.org/core/terms (unspecified)
Locations: Psychological Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Digital Commons@Becker (Washington University School of Medicine) (submittedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health
National Institute on Aging (R01AG045231, AG045231)
National Institute of Mental Health (MH014677, T32MH014677)
National Institute on Drug Abuse (MH014677, R01DA033369, DA031579, DA033369, R01DA031579)
National Institute of General Medical Sciences (T32GM008151, T32GM081739)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: early life stress, anhedonia, ventral striatum, reward processing, depression, alcohol abuse, substance use coping, transdiagnostic symptoms, moderating effect
MeSH terms: Adaptation, Psychological, Adolescent, Adult, Alcohol Drinking, Depression, Female, Humans, Magnetic Resonance Imaging, Male, North Carolina, Psychological Tests, Reward, Stress, Psychological, Students, Universities, Linear Models, Sex Distribution, Young Adult, Anhedonia, Ventral Striatum

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Stress-related anhedonia is associated with ventral striatum reactivity to reward and transdiagnostic psychiatric symptomatology

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