The DOI matches its Crossref record; 139 of the 139 references it cites were found in a registry or an index.
The slow death of the concept of schizophrenia and the painful birth of the psychosis spectrum
Open accessAbstract
The concept of schizophrenia only covers the 30% poor outcome fraction of a much broader multidimensional psychotic syndrome, yet paradoxically has become the dominant prism through which everything ‘psychotic’ is observed, even affective states with mild psychosis labelled ‘ultra-high risk’ (for schizophrenia). The inability of psychiatry to frame psychosis as multidimensional syndromal variation of largely unpredictable course and outcome – within and between individuals – hampers research and recovery-oriented practice. ‘Psychosis’ remains firmly associated with ‘schizophrenia’, as evidenced by a vigorous stream of high-impact but non-replicable attempts to ‘reverse-engineer’ the hypothesized biological disease entity, using case–control paradigms that cannot distinguish between risk for illness onset and risk for poor outcome. In this paper, the main issues surrounding the concept of schizophrenia are described. We tentatively conclude that with the advent of broad spectrum phenotypes covering autism and addiction in DSM5, the prospect for introducing a psychosis spectrum disorder – and modernizing psychiatry – appears to be within reach.
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Cites
Why Most Published Research Findings Are False
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Why Most Published Research Findings Are False
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Defining the clinical course of multiple sclerosis: The 2013 revisions
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Self-citationGenetic relationship between five psychiatric disorders estimated from genome-wide SNPs
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Cited by
Progress in achieving quantitative classification of psychopathology
Krueger, R. F., Kotov, R., Watson, D., Forbes, M. K., Eaton, N. R., Ruggero, C. J., Simms, L. J., Widiger, T. A., Achenbach, T. M., Bach, B., et al. (2018) · World Psychiatry · doi:10.1002/wps.20566 · Cited by 490
What is the risk‐benefit ratio of long‐term antipsychotic treatment in people with schizophrenia?
Correll, C. U., Rubio, J. M., & Kane, J. M. (2018) · World Psychiatry · doi:10.1002/wps.20516 · Cited by 324
Murray, R. M., Bhavsar, V., Tripoli, G., & Howes, O. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx121 · Cited by 312
Heart rate variability is associated with disease severity in psychosis spectrum disorders
Benjamin, B. R., Valstad, M., Elvsåshagen, T., Jönsson, E. G., Moberget, T., Winterton, A., Haram, M., Høegh, M. C., Lagerberg, T. V., Steen, N. E., et al. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110108 · Cited by 52
Psychosis Risk and Development: What Do We Know From Population-Based Studies?
Mennigen, E., & Bearden, C. E. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.12.014 · Cited by 40
“It is increasingly recognized that most categorically defined psychiatric disorders (i) occur on a spectrum or continuum (1) that is not necessarily normally distributed (2), (ii) show high heterogeneity and symptom overlap, and (iii) share genetic and environmental risk factors (3,4).”
Background
Metadata
- Authors
- Guloksuz, S., & van Os, J.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2017-07-10
- Volume
- 48
- Issue
- 2
- Pages
- 229-244
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2735511385
- Cited by
- 325
- References
- 139
- FWCI
- 23.71
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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