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Childhood adversity and adult psychiatric disorder in the US National Comorbidity Survey
Abstract
BACKGROUND: Survey data are presented on the associations between retrospectively reported childhood adversities and subsequent onset and persistence of DSM-III-R disorders. METHODS: Data come from the US National Comorbidity Survey, a large survey of the US household population. RESULTS: Twenty-six adversities were considered, including loss events (e.g. parental divorce), parental psychopathologies (e.g. maternal depression), interpersonal traumas (e.g. rape) and other adversities (e.g. natural disaster). These adversities were consistently associated with onset, but not persistence, of DSM-III-R mood disorders, anxiety disorders, addictive disorders and acting out disorders. Most bivariate associations with onset attenuated in models that controlled for clustering of adversities and for lifetime co-morbidities among psychiatric disorders. Multivariate effects of adversities in logistic models were additive, which means that they have multiplicative effects on probability of disorder onset. Adversities showed little specificity. An analysis of time decay showed that the effects of childhood adversities on disorder onset persist beyond childhood. CONCLUSIONS: The existence of strong clustering among childhood adversities and lifetime co-morbidity among adult disorders means that caution is needed in interpreting the results of previous single-adversity single-disorder studies as documenting unique effects of specific childhood adversities on specific adult disorders. Future studies need to assess a broader range of adversities and disorders and to explore the existence and effects of commonly occurring adversity clusters. Replication is needed to verify that the effects of childhood adversities are mostly on first onset rather than on the creation of vulnerabilities that lead to increased risk of persistence.
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“Childhood adversities are widely prevalent and often co-occur in general populations (Kessler et al. 1997; Finkelhor et al. 2015).”
From Childhood adversity, adult stress, and the risk of major depression or generalized anxiety disorder in US soldiers: a test of the stress sensitization hypothesis (2017) · cites this paper as Kessler et al. 1997
In the citing paper
“Individuals exposed to childhood adversity have increased risk of mood, anxiety, behavioral and substance abuse disorders which do not display specificity to the type of adversity (Kessler et al. 1997; McLaughlin 2016).”
From Childhood adversity, adult stress, and the risk of major depression or generalized anxiety disorder in US soldiers: a test of the stress sensitization hypothesis (2017) · cites this paper as Kessler et al. 1997
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Metadata
- Authors
- KESSLER, R. C., DAVIS, C. G., & KENDLER, K. S.
- Affiliations
- Harvard University (US)
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 1997-09
- Volume
- 27
- Issue
- 5
- Pages
- 1101-1119
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2067908853
- Cited by
- 1,298
- References
- 0
- Citations by year
- 2026: 17 · 2025: 27 · 2024: 29 · 2023: 36 · 2022: 48 · 2021: 47 · 2020: 47 · 2019: 45 · 2018: 52 · 2017: 67 · 2016: 67 · 2015: 73 · 2014: 63 · 2013: 59 · 2012: 77
- FWCI
- 16.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh052861-04)
- National Institute of Mental Health (MH52861, R01MH046376, R01 MH46376, R01-MH49098, R01MH049098)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Keywords
- childhood adversity, adult psychiatric disorders, mood disorders, anxiety disorders, addiction, comorbidities, parental divorce, maternal depression, interpersonal trauma, natural disasters, DSM-III-R, National Comorbidity Survey
- MeSH terms
- Adolescent, Adult, Anxiety Disorders, Mental Disorders, Child, Child Rearing, Cross-Sectional Studies, Family Health, Female, Health Surveys, Humans, Life Change Events, Male, Middle Aged, Retrospective Studies, Time Factors, United States, Comorbidity, Causality, Prevalence, Confidence Intervals, Chi-Square Distribution, Likelihood Functions, Logistic Models, Odds Ratio, Survival Analysis, Child of Impaired Parents, Age of Onset, Mood Disorders, Substance-Related Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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