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Cited by 175Neurotransmitter Receptor Influence on BehaviorNeuroendocrine regulation and behaviorObsessive-Compulsive Spectrum Disorders

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Alteration of the platelet serotonin transporter in romantic love

MARAZZITI, D., AKISKAL, H. S., ROSSI, A., CASSANO, G. B.·1999·Psychological Medicine
DOI 10.1017/s0033291798007946
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Abstract

BACKGROUND: The evolutionary consequences of love are so important that there must be some long-established biological process regulating it. Recent findings suggest that the serotonin (5-HT) transporter might be linked to both neuroticism and sexual behaviour as well as to obsessive-compulsive disorder (OCD). The similarities between an overvalued idea, such as that typical of subjects in the early phase of a love relationship, and obsession, prompted us to explore the possibility that the two conditions might share alterations at the level of the 5-HT transporter. METHODS: Twenty subjects who had recently (within the previous 6 months) fallen in love, 20 unmedicated OCD patients and 20 normal controls, were included in the study. The 5-HT transporter was evaluated with the specific binding of 3H-paroxetine (3H-Par) to platelet membranes. RESULTS: The results showed that the density of 3H-Par binding sites was significantly lower in subjects who had recently fallen in love and in OCD patients than in controls. DISCUSSION: The main finding of the present study is that subjects who were in the early romantic phase of a love relationship were not different from OCD patients in terms of the density of the platelet 5-HT transporter, which proved to be significantly lower than in the normal controls. This would suggest common neurochemical changes involving the 5-HT system, linked to psychological dimensions shared by the two conditions, perhaps at an ideational level.

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Metadata

Authors
MARAZZITI, D., AKISKAL, H. S., ROSSI, A., & CASSANO, G. B.
Affiliations
University of Pisa (IT)
ORCID
Venue
Psychological Medicine
Publisher
Cambridge University Press (CUP)
Published
1999-05
Volume
29
Issue
3
Pages
741-745
ISSN
  • 0033-2917 (ISSN-L)
  • 1469-8978
DOI
10.1017/s0033291798007946
OpenAlex
W2006411360
Cited by
175
References
27
Citations by year
2026: 8 · 2025: 14 · 2024: 7 · 2023: 7 · 2022: 7 · 2021: 7 · 2020: 6 · 2019: 3 · 2018: 7 · 2017: 14 · 2016: 6 · 2015: 6 · 2014: 10 · 2013: 4 · 2012: 15
FWCI
0.60
Type
journal article
Language
en
Open access
closed
Licence
www.cambridge.org/core/terms (unspecified)
Locations
  • Psychological Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
Keywords
platelet serotonin transporter, romantic love, obsessive-compulsive disorder, serotonergic system, overvalued ideas, obsession, neuroticism, sexual behavior, evolution of love
MeSH terms
Adult, Binding Sites, Biological Transport, Buffers, Female, Humans, Interpersonal Relations, Love, Male, Obsessive-Compulsive Disorder, Serotonin, Sexual Behavior, Selective Serotonin Reuptake Inhibitors, Paroxetine

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