The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Alteration of the platelet serotonin transporter in romantic love
Abstract
BACKGROUND: The evolutionary consequences of love are so important that there must be some long-established biological process regulating it. Recent findings suggest that the serotonin (5-HT) transporter might be linked to both neuroticism and sexual behaviour as well as to obsessive-compulsive disorder (OCD). The similarities between an overvalued idea, such as that typical of subjects in the early phase of a love relationship, and obsession, prompted us to explore the possibility that the two conditions might share alterations at the level of the 5-HT transporter. METHODS: Twenty subjects who had recently (within the previous 6 months) fallen in love, 20 unmedicated OCD patients and 20 normal controls, were included in the study. The 5-HT transporter was evaluated with the specific binding of 3H-paroxetine (3H-Par) to platelet membranes. RESULTS: The results showed that the density of 3H-Par binding sites was significantly lower in subjects who had recently fallen in love and in OCD patients than in controls. DISCUSSION: The main finding of the present study is that subjects who were in the early romantic phase of a love relationship were not different from OCD patients in terms of the density of the platelet 5-HT transporter, which proved to be significantly lower than in the normal controls. This would suggest common neurochemical changes involving the 5-HT system, linked to psychological dimensions shared by the two conditions, perhaps at an ideational level.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In addition, research has shown that the early stages of romantic love may be linked to alterations in plasma levels of cortisol, sex steroids, nerve growth factor (NGF), and brain derived neurotrophic factor (BDNF) (Marazziti et al., 2009), as well as decreased density of the serotonin transporter in platelets (Emanuele et al., 2006; Marazziti et al., 1999; Marazziti and Canale, 2004), suggesting”
From Oxytocin during the initial stages of romantic attachment: Relations to couples’ interactive reciprocity (2012) · cites this paper as Marazziti et al., 1999
Citations
Cites
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
The Yale-Brown Obsessive Compulsive Scale: I. Development, Use, and Reliability
Goodman, W. K. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810110048007 · Cited by 7,712
Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Müller, C. R., Hamer, D. H., & Murphy, D. L. (1996) · Science · doi:10.1126/science.274.5292.1527 · Cited by 5,162
A unified biosocial theory of personality and its role in the development of anxiety states.
Cr, C. (1986) · PubMed · Cited by 1,090
Statistical Package for the Social Sciences (SPSS)
(2008) · Encyclopedia of Survey Research Methods · doi:10.4135/9781412963947.n549 · Cited by 961
Cyclothymic disorder: validating criteria for inclusion in the bipolar affective group
Akiskal, H. S., Djenderedjian, A., Rosenthal, R. H., & Khani, M. K. (1977) · American Journal of Psychiatry · doi:10.1176/ajp.134.11.1227 · Cited by 599
Efficacy and Tolerability of Serotonin Transport Inhibitors in Obsessive-compulsive Disorder
Greist, J. H. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950130053006 · Cited by 498
Zohar, J., & Insel, T. R. (1987) · Biological Psychiatry · doi:10.1016/0006-3223(87)90199-5 · Cited by 416
Obsessive-compulsive disorder with psychotic features: a phenomenologic analysis
Insel, T. R., & Akiskal, H. S. (1986) · American Journal of Psychiatry · doi:10.1176/ajp.143.12.1527 · Cited by 349
Obsessive-compulsive disorder and serotonin: Is there a connection?
Insel, T. R., Mueller, E. A., Alterman, I., Linnoila, M., & Murphy, D. L. (1985) · Biological Psychiatry · doi:10.1016/0006-3223(85)90176-3 · Cited by 343
Cited by
Sorted by citations
Romantic love: a mammalian brain system for mate choice
Fisher, H. E., Aron, A., & Brown, L. L. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1938 · Cited by 411
Schneiderman, I., Zagoory-Sharon, O., Leckman, J. F., & Feldman, R. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.12.021 · Cited by 333
“…neurotrophic factor (BDNF) (Marazziti et al., 2009), as well as decreased density of the serotonin transporter in platelets (Emanuele et al., 2006; Marazziti et al., 1999; Marazziti and Canale, 2004), suggesting that the initial period of romantic attachment is linked with neuroendocrine changes.”
Hormonal changes when falling in love
Marazziti, D., & Canale, D. (2003) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2003.08.006 · Cited by 223
“The strong suggestion is that different mechanisms may be involved (Panksepp, 1982; Jankoviak, 1986; Hazan and Shaver, 1987; Fisher, 1992; Porges, 1998; Insel and Young, 1997) and it has been recently demonstrated that the intrusive thoughts of the early, romantic phase of a falling in love are underlaid by a decrease…”
BackgroundMethodFisher, H. E., Xu, X., Aron, A. P., & Brown, L. L. (2016) · Frontiers in Psychology · doi:10.3389/fpsyg.2016.00687 · Cited by 241
“However, in most species courtship attraction is brief, lasting only minutes, hours, days, or weeks; while in humans, intense, early stage romantic love can last 12–18 months (Marazziti et al., 1999) or much longer (Acevedo et al., 2011).”
BackgroundFisher, H. (2000) · Journal of Sex Education and Therapy · doi:10.1080/01614576.2000.11074334 · Cited by 159
The Brain Reaction to Viewing Faces of Opposite- and Same-Sex Romantic Partners
Zeki, S., & Romaya, J. P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015802 · Cited by 157
“They include oxytocin, vasopressin (both synthesised in the hypothalamus) [28], serotonin [29] (also present in the hypothalamus) and norepinephrine [23,30].”
BackgroundLymphocytes transport serotonin and dopamine: agony or ecstasy?
Gordon, J., & Barnes, N. M. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(03)00176-5 · Cited by 140
If I Could Just Stop Loving You: Anti-Love Biotechnology and the Ethics of a Chemical Breakup
Earp, B. D., Wudarczyk, O. A., Sandberg, A., & Savulescu, J. (2013) · The American Journal of Bioethics · doi:10.1080/15265161.2013.839752 · Cited by 129
“Indeed, retesting the lovers at 12–18 months revealed that serotonin levels had returned to baseline—at which point their “obsessive ideation regarding the partner” had disappeared as well (Marazziti et al. 1999, 744).”
BackgroundInfluentialLove is more than just a kiss: a neurobiological perspective on love and affection
de Boer, A., van Buel, E. M., & Ter Horst, G. J. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2011.11.017 · Cited by 123
“Further similarities between obsessive behavior and early romantic love were elucidated by Marazziti et al. (1999), who evaluated platelet serotonin transporter levels in OCD patients and subjects who had recently fallen in love.”
InfluentialLove addiction: definition, etiology, treatment
Sussman, S. (2010) · Sexual Addiction & Compulsivity · doi:10.1080/10720161003604095 · Cited by 119
“Healthy romantic love has an evolutionary basis (for procreation), biological roots (eg, neurotransmission-related), cognitive and social learning aspects (eg, attachment development), and cultural features (eg, mass media depictions of romance and family creation) ( Fisher, 2006 ; Gordon, 2007 ; Marazziti, Akiskal, R…”
BackgroundEvent-related potential responses to love-related facial stimuli
Langeslag, S. J. E., Jansma, B. M., Franken, I. H. A., & Strien, J. W. V. (2007) · Biological Psychology · doi:10.1016/j.biopsycho.2007.06.007 · Cited by 114
“Some researchers have, however, assumed that romantic love usually lasts no more than 18 months (Fisher et al., 2002; Marazziti et al., 1999), where after it may convert into a much calmer state, namely attachment.”
Raised plasma nerve growth factor levels associated with early-stage romantic love
Emanuele, E., Politi, P., Bianchi, M., Minoretti, P., Bertona, M., & Geroldi, D. (2006) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.09.002 · Cited by 105
“To date, the neurochemical bases of love in humans have only been studied in one investigation, which found that the intrusive thoughts of the early romantic phase of a falling in love could be due to a reduced functionality of the serotonin transporter (Marazziti et al., 1999).”
BackgroundThe cognitive-affective neuroscience of obsessive-compulsive disorder
Stein, D. J., Goodman, W. K., & Rauch, S. L. (2000) · Current Psychiatry Reports · doi:10.1007/s11920-000-0079-2 · Cited by 100
Proximate and Ultimate Perspectives on Romantic Love
Bode, A., & Kushnick, G. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.573123 · Cited by 114
Conversano, C., Marazziti, D., Carmassi, C., Baldini, S., Barnabei, G., & Dell’Osso, L. (2012) · Harvard Review of Psychiatry · doi:10.3109/10673229.2012.694318 · Cited by 104
Treatment of love addiction: Current status and perspectives
Sanches, M., & John, V. P. (2018) · The European Journal of Psychiatry · doi:10.1016/j.ejpsy.2018.07.002 · Cited by 95
Feygin, D. L., Swain, J. E., & Leckman, J. F. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.01.009 · Cited by 93
Schneiderman, I., Kanat‐Maymon, Y., Ebstein, R. P., & Feldman, R. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst142 · Cited by 90
“…research the communicative empathy construct was averaged from several scales coded for each partner and included the following codes: affective congruence, emotional flow and harmony, degree of emotional coherence and complexity, nonverbal signs of empathy particularly the provision of…”
Some Thoughts on the Neurobiology of Stalking
Meloy, J. R., & Fisher, H. E. (2005) · Journal of Forensic Sciences · doi:10.1520/jfs2004508 · Cited by 81
“In this experiment 20 men and women who had fallen in love in the previous six months, 20 who suffered from unmedicated obsessive-compulsive disorder (OCD), and 20 normal (control) individuals who were not in love were tested for plasma levels of serotonin (78).”
Schneiderman, I., Kanat‐Maymon, Y., Zagoory‐Sharon, O., & Feldman, R. (2014) · Social Neuroscience · doi:10.1080/17470919.2014.893925 · Cited by 74
Normal and obsessional jealousy: a study of a population of young adults
Marazziti, D., Nasso, E. D., Másala, I., Baroni, S., Abelli, M., Mengali, F., Mungai, F., & Rucci, P. (2003) · European Psychiatry · doi:10.1016/s0924-9338(03)00024-5 · Cited by 64
“Recently, we proposed a dimensional model along the “uncertainty/ certainty” and “insight/no insight” dimensions, possibly related to the 5-HT system [18], spanning from the pole of normality to the opposite side of delusional severity, where several and different conditions can be located.”
(2010) · Choice Reviews Online · doi:10.5860/choice.48-0567 · Cited by 61
Blood Levels of Serotonin Are Differentially Affected by Romantic Love in Men and Women
Langeslag, S. J. E., van der Veen, F. M., & Fekkes, D. (2012) · Journal of Psychophysiology · doi:10.1027/0269-8803/a000071 · Cited by 54
“Furthermore, the previous finding of a reduced platelet serotonin transporter density during romantic love (Marazziti et al., 1999) and the notion that this transporter transports serotonin back into the cell (e.”
BackgroundResultInfluentialGenetic loading on human loving styles.
Emanuele, E., Brondino, N., Pesenti, S., Re, S., & Geroldi, D. (2007) · PubMed · Cited by 46
Measuring Romantic Love: Psychometric Properties of the Infatuation and Attachment Scales
Langeslag, S. J. E., Muris, P., & Franken, I. H. A. (2012) · The Journal of Sex Research · doi:10.1080/00224499.2012.714011 · Cited by 48
“…levels are thought to vary over time, with infatuation diminishing with time and attachment increasing with time (Ahmetoglu et al., 2010; Fisher, 1998, 2000; Fisher et al., 2002; Marazziti et al., 1999; Sprecher & Regan, 1998), the two factors could be expected to be negatively correlated.”
BackgroundResultYamada, J., Kito, M., & Yuki, M. (2017) · Evolutionary Psychology · doi:10.1177/1474704917746056 · Cited by 47
Falling in love is associated with immune system gene regulation
Murray, D. R., Haselton, M. G., Fales, M. R., & Cole, S. W. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.09.043 · Cited by 39
“Other work has found that new romantic love is associated with lower densities of specific serotonin transporter binding sites—densities that were equivalent to those found in individuals suffering from obsessive-compulsive disorder (Marazziti et al., 1999).”
BackgroundPathological Love: Impulsivity, Personality, and Romantic Relationship
Sophia, E. C., Tavares, H., Berti, M. P., Pereira, A. P., Lorena, A., Mello, C., Gorenstein, C., & Zilberman, M. L. (2009) · CNS Spectrums · doi:10.1017/s1092852900025438 · Cited by 40
Pinto, S. (2017) · Rethinking History · doi:10.1080/13642529.2017.1333288 · Cited by 39
“…or biological markers of romantic love have also noted the similarities between romantic love and other behaviors including addiction (Reis and Aron 2008) and obsessive-compulsive disorders (Marazziti et al. 1999), suggesting the emotion shares many features with other behaviors or experiences.”
BackgroundLatest Advancements on Serotonin and Dopamine Transporters in Lymphocytes
Marazziti, D., Consoli, G., Másala, I., Dell’Osso, M. C., & Baroni, S. (2010) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955710791112587 · Cited by 37
Decreased Density of the Platelet Serotonin Transporter in Pathological Gamblers
Marazziti, D., Golia, F., Picchetti, M., Pioli, E., Mannari, P., Lenzi, F., Conversano, C., Carmassi, C., Dell’Osso, M. C., Consoli, G., et al. (2008) · Neuropsychobiology · doi:10.1159/000129665 · Cited by 36
“Moreover, there exist also indications of changes of SERT in healthy subjects [”
BackgroundPlatelet Serotonergic Markers as Endophenotypes for Obsessive-Compulsive Disorder
Delorme, R., Betancur, C., Callebert, J., Chabane, N., Laplanche, J., Mouren, M., Launay, J., & Leboyer, M. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300752 · Cited by 37
“…whole blood or platelet 5-HT levels, whereas the binding capacity (Bmax) of the platelet 5-HTT is consistently reduced, both for [3H]-paroxetine (Marazziti et al. 1999; Sallee et al. 1996) and [3H]-imipramine (Bastani et al. 1991; Marazziti et al. 1992; Marazziti et al. 1997; Weizman et al.…”
The Evolution of Human Social Behavior
Grinde, B. (2024) · Encyclopedia · doi:10.3390/encyclopedia4010029 · Cited by 36
Love as delusion, delusions of love: erotomania, narcissism and shame
Kelly, B. D. (2017) · Medical Humanities · doi:10.1136/medhum-2017-011198 · Cited by 35
Prefrontal cortex, dopamine, and jealousy endophenotype
Marazziti, D., Poletti, M., Dell’Osso, L., Baroni, S., & Bonuccelli, U. (2012) · CNS Spectrums · doi:10.1017/s1092852912000740 · Cited by 32
Leonti, M., & Casu, L. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00567 · Cited by 33
“Neurochemistry of Love Human attraction and romantic love is based on a complex neurobiological network involving altered levels of dopamine, noradrenalin and serotonin (5-HT; 2F), three neurotransmitters also associated with sexual arousal, motivation and obsessive thinking (Marazziti et al., 1999; Meston and Frohlic…”
BackgroundPlatelet Serotonergic Predictors of Clinical Improvement in Obsessive Compulsive Disorder
Delorme, R., Chabane, N., Callebert, J., Falissard, B., Mouren, M., Rouillon, F., Launay, J., & Leboyer, M. (2004) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000104905.75206.50 · Cited by 33
Love alters autonomic reactivity to emotions.
Schneiderman, I., Zilberstein-Kra, Y., Leckman, J. F., & Feldman, R. (2011) · Emotion · doi:10.1037/a0024090 · Cited by 37
Romantic love evolved by co-opting mother-infant bonding
Bode, A. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1176067 · Cited by 32
Pismenny, A., & PRINZ, J. J. (2017) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780199395729.013.10 · Cited by 32
Langeslag, S. J. E., Olivier, J. R., Köhlen, M. E., Nijs, I. M. T., & Strien, J. W. V. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu034 · Cited by 29
“Generally, infatuation decreases over time, whereas attachment increases over time (Fisher, 1998, 2000; Marazziti et al., 1999; Fisher et al., 2002; Marazziti and Canale, 2004; Langeslag et al., 2013).”
Obsessive versus delusional jealousy.
Batinić, B., Duišin, D., & Barišić, J. (2013) · PubMed · Cited by 28
Neuroimaging of the Serotonin Transporter: Possibilities and Pitfalls
Brust, P., Hesse, S., Müller, U., & Szabó, Z. R. (2005) · Current Psychiatry Reviews · doi:10.2174/157340006775101508 · Cited by 29
Love and Attachment: The Psychobiology of Social Bonding
Stein, D. J., & Vythilingum, B. (2009) · CNS Spectrums · doi:10.1017/s1092852900025384 · Cited by 28
Bajoghli, H., Joshaghani, N., Gerber, M., Mohammadi, M.-R., Holsboer‐Trachsler, E., & Brand, S. (2012) · International Journal of Psychiatry in Clinical Practice · doi:10.3109/13651501.2012.697564 · Cited by 26
Jealousy and Subthreshold Psychopathology: A Serotonergic Link
Marazziti, D., Rucci, P., Nasso, E. D., Másala, I., Baroni, S., Rossi, A., Giannaccini, G., Mengali, F., & Lucacchini, A. (2003) · Neuropsychobiology · doi:10.1159/000068869 · Cited by 27
Feybesse, C., & Hatfield, E. C. (2018) · Cambridge University Press eBooks · doi:10.1017/9781108658225.010 · Cited by 23
Bode, A., & Kowal, M. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.983419 · Cited by 25
The Effects of Romantic Love on Mentalizing Abilities
Wlodarski, R., & Dunbar, R. (2014) · Review of General Psychology · doi:10.1037/gpr0000020 · Cited by 27
Psychotropic medication, psychiatric disorders, and higher brain functions
Schulz, P., & Steimer, T. J. (2000) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2000.2.3/pschulz · Cited by 22
Newberg, A. B., Wintering, N., Yaden, D. B., Zhong, L., Bowen, B., Averick, N., & Monti, D. (2017) · Religion Brain & Behavior · doi:10.1080/2153599x.2016.1267035 · Cited by 26
Cultural Diversity of Romantic Love Experience
Karandashev, V. N. (2021) · Springer eBooks · doi:10.1007/978-3-030-45996-3_4 · Cited by 21
Zayas, V., Günaydın, G., & Shoda, Y. (2015) · Springer eBooks · doi:10.1007/978-1-4614-9622-9_8 · Cited by 21
“Infatuation manifests itself as constantly thinking about (Marazziti et al. 1999) and longing to be with the person (Aron et al.”
BackgroundThe Science of Love: State of the Art
Marazziti, D., Palermo, S., & Mucci, F. (2021) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-030-74046-7_16 · Cited by 20
Decreased lymphocyte dopamine transporter in romantic lovers
Marazziti, D., Baroni, S., Giannaccini, G., Piccinni, A., Mucci, F., Catena-Dell’Osso, M., Rutigliano, G., Massimetti, G., & Dell’Osso, L. (2016) · CNS Spectrums · doi:10.1017/s109285291600050x · Cited by 20
“Lymphocytes separation and membrane preparation for binding assay with [(3)H]-WIN 35,428 were carried out according to our method.(2) The [(3)H]-DA reuptake was performed according to the method of Amenta et al,(28) with slight modifications.”
BackgroundMethodThermal balneotherapy induces changes of the platelet serotonin transporter in healthy subjects
Marazziti, D., Baroni, S., Giannaccini, G., Dell’Osso, M. C., Consoli, G., Picchetti, M., Carlini, M., Massimetti, G., Provenzano, S., & Galassi, A. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.06.025 · Cited by 19
Stalking: a neurobiological perspective
Marazziti, D., Falaschi, V., Lombardi, A., Mungai, F., & Dell’Osso, L. (2015) · Rivista di psichiatria · doi:10.1708/1794.19528 · Cited by 18
Zoratto, F., Romano, E., Pascale, E., Pucci, M., Falconi, A., Dell’Osso, B. M., Maccarrone, M., Giovanni Laviola, A., D’Addario, C., & Adriani, W. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.10.041 · Cited by 18
Fisher, H. E. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407724-9.00010-0 · Cited by 19
Fundamental Factors in Marital Satisfaction: An Assessment of Brazilian Couples
Rebello, K., Júnior, M. D. S., & Brito, R. C. S. (2014) · Psychology · doi:10.4236/psych.2014.57088 · Cited by 19
Chemistry—A Central Pillar of Human Culture
Shaik, S. S. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200330038 · Cited by 17
Watanuki, S. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.984647 · Cited by 17
“The density of serotonin transporters has an influence on the mental processes of infatuated couples such as obsessions with partners (Marazziti et al., 1999; Langeslag et al., 2012).”
BackgroundThe Relationships Between Obsessive-Compulsive Disorder and Psychosis: An Unresolved Issue.
Palermo, S., Marazziti, D., Baroni, S., Barberi, F. M., & Mucci, F. (2020) · PubMed Central · doi:10.36131/cnfioritieditore20200302 · Cited by 16
Romantic Love Is Associated with Enhanced Inhibitory Control in an Emotional Stop-Signal Task
Song, S., Zou, Z., Song, H., Wang, Y.-M., Uquillas, F. D., Wang, H., & Chen, H. (2016) · Frontiers in Psychology · doi:10.3389/fpsyg.2016.01574 · Cited by 18
“This early phase is also characterized by low serotonin levels (Marazziti et al., 1999) and high nerve growth factor (Emanuele et al., 2006).”
BackgroundResultZheng, X., Xu, X., Xu, L., Kou, J., Luo, L., Ma, X., & Kendrick, K. M. (2021) · Journal of Psychopharmacology · doi:10.1177/0269881121991576 · Cited by 17
“Several studies have indicated an involvement of the serotonergic system in jealousy and treatment with serotonin selective re-uptake inhibitors has been reported to have beneficial effects (Marazziti et al., 1999, 2003).”
BackgroundBajoghli, H., Farnia, V., Joshaghani, N., Haghighi, M., Jahangard, L., Ahmadpanah, M., Bahmani, D. S., Holsboer‐Trachsler, E., & Brand, S. (2017) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2016-2126 · Cited by 17
An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
Emanuele, E., Bertona, M., Minoretti, P., & Geroldi, D. (2010) · PubMed · Cited by 15
Endocrine factors of pair bonding.
Stárka, L. (2007) · PubMed · Cited by 15
Girard, A., Connor, J. J., & Woolley, S. R. (2018) · Journal of Marital and Family Therapy · doi:10.1111/jmft.12371 · Cited by 13
Low Resting Heart Rate and Stalking Perpetration
Boisvert, D. L., Wells, J., Armstrong, T. A., Lewis, R. H., Woeckener, M., & Nobles, M. R. (2017) · Journal of Interpersonal Violence · doi:10.1177/0886260517698823 · Cited by 12
Reverse Correlating Love: Highly Passionate Women Idealize Their Partner’s Facial Appearance
Günaydın, G., & DeLong, J. E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121094 · Cited by 12
“There has long been interest in passionate love—an intense state of romantic attraction [1] associated with reward-related activation in the brain [2–4], physiological arousal [5], and mental preoccupation with the partner [6].”
BackgroundParoxetine reduces crying in young women watching emotional movies
van der Veen, F. M., Jorritsma, J., Krijger, C., & Vingerhoets, A. J. J. M. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2477-z · Cited by 12
“Finally, preliminary data suggest that being in love is accompanied by low 5-HT levels (Marazziti et al. 1999) and a greater crying proneness (Vingerhoets and van Assen 2009).”
BackgroundMarazziti, D., & Stahl, S. M. (2017) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000808 · Cited by 11
“It has been reported that a decreased function of 5-HT might be related to romantic love and, particularly, to what is considered its main feature, that is to say a sort of transient obsessional thoughts related to the partner.(5) Such a physiological form of OCD is considered essential to maintain the focus on the pa…”
BackgroundRomantic Love and Sleep Variations: Potential Proximate Mechanisms and Evolutionary Functions
Bode, A., & Kuula, L. (2021) · Biology · doi:10.3390/biology10090923 · Cited by 13
“Two studies [24,27] have identified changes in serotonin levels in people experiencing romantic love.”
BackgroundWhat came first: dimensions or categories?
Marazziti, D. (2001) · The British Journal of Psychiatry · doi:10.1192/bjp.178.5.478-b · Cited by 10
13. Passionate Love : Cross-Cultural and Evolutionary Perspectives
Lieberman, D., & Hatfield, E. C. (2017) · Yale University Press eBooks · doi:10.12987/9780300159318-015 · Cited by 10
Genes and psychology in the news
Ratner, C. (2004) · New Ideas in Psychology · doi:10.1016/j.newideapsych.2004.05.001 · Cited by 10
Sex differences in romantic love: an evolutionary perspective
Bode, A., Luoto, S., & Kavanagh, P. S. (2025) · Biology of Sex Differences · doi:10.1186/s13293-025-00698-4 · Cited by 22
“…the evolution of romantic love [12, 41], surprisingly lit - tle research has been undertaken on the phenomenon of obsessive thinking (see [8, 20, 68, 69, 39 for exceptions), and no one has provided a likely explanation of its functions in romantic love (although note the suggestion of [68]).”
Dundon, C. M., & Rellini, A. H. (2012) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2012.02799.x · Cited by 8
Selective Serotonin Reuptake Inhibitors and Their Effects on Relationship Satisfaction
Meyer, D. (2007) · The Family Journal · doi:10.1177/1066480707305470 · Cited by 10
CortiLove: A pilot study on hair steroids in the context of being in love and separation
Renner, J., Stanulla, M., Walther, A., & Schindler‐Gmelch, L. (2021) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2021.100061 · Cited by 6
“Further, the chosen control groups greatly vary with individuals in long-term relationships [25], singles [1,16,25], mixed groups [15], or unspecified "healthy controls" [26].”
BackgroundThe meaning of love in the debate for legal recognition of same-sex marriage in Australia
Grossi, R. (2012) · International Journal of Law in Context · doi:10.1017/s1744552312000341 · Cited by 8
Cross-Cultural Methods in Sexual Psychology: Love Research
Kowal, M. (2023) · Springer eBooks · doi:10.1007/978-3-031-08956-5_734-1 · Cited by 8
Babková, J., & Repiská, G. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041533 · Cited by 8
“One study investigated the effects of naloxone, an opioid antagonist, on female sexual response.”
An Overview of Love Between Humans and Artificial Partners
Cheok, A. D., & Zhang, E. Y. (2019) · Human–Robot Intimate Relationships · doi:10.1007/978-3-319-94730-3_1 · Cited by 6
The Brain in Love: Has Neuroscience Stolen the Secret of Love?
Tarlacı, S. (2012) · NeuroQuantology · doi:10.14704/nq.2012.10.4.581 · Cited by 7
Antidepressant Psychopharmacology and the Social Brain
Novick, A. M. (2011) · Psychiatry · doi:10.1521/psyc.2011.74.1.72 · Cited by 7
“, & Cassano, G. B. (1999). Alteration of the platelet serotonin transporter in romantic love.”
BackgroundInfluentialEight survival strategies in traumatic stress.
Valent, P. (2007) · Traumatology An International Journal · doi:10.1177/1534765607302281 · Cited by 9
Die Chemie – eine zentrale Säule der menschlichen Kultur
Shaik, S. S. (2003) · Angewandte Chemie · doi:10.1002/ange.200230038 · Cited by 7
Emotions, Facultative Adaptation, and the History of Homicide
Roth, R. A. (2014) · The American Historical Review · doi:10.1093/ahr/119.5.1529 · Cited by 9
“Beyond Emotion: Love as an Encounter of Myth and Drive” by Lubomir Lamy
Marazziti, D. (2015) · Emotion Review · doi:10.1177/1754073915594437 · Cited by 7
Bode, A., & Kavanagh, P. S. (2025) · Personality and Individual Differences · doi:10.1016/j.paid.2025.113108 · Cited by 8
Abordaje de la sexualidad en atención primaria: ¿qué valorar?
Figueroa-Martín, L., Clíments, G. D., Gómez, M. B. S., & Brito, P. R. B. (2015) · Ene · doi:10.4321/s1988-348x2015000200006 · Cited by 6
McLauchlan, J., Thompson, E. M., Ferrão, Y. A., Miguel, E. C., Albertella, L., Marazziti, D., & Fontenelle, L. F. (2021) · CNS Spectrums · doi:10.1017/s1092852921000444 · Cited by 7
“Possible total scores for the BAI ranges from 0 (low) to 63 (high); depending on the score, the anxiety level can be interpreted as “minimal” (0-7), “mild” (8-15), “moderate” (16-25), or “severe” (26-63).”
BackgroundDoherty, J. K., & Brumbaugh, C. C. (2024) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780197544754.013.10 · Cited by 5
Marazziti, D., Massa, L., Carbone, M. G., Palermo, S., Arone, A., D'Angelo, G., Crivelli, N. S. B., Gurrieri, R., Perrone, P., Palagini, L., et al. (2024) · PubMed Central · doi:10.36131/cnfioritieditore20240101 · Cited by 6
“…levels of interleukins (IL) IL-2, IL-4, IL-6, IL-10 and tumor necrosis factor-α (TNF-α) in adult OCD patients, compared to controls (Brambilla et al, 1997; Marazziti et al., 1999; 2018, Fontenelle et al., 2012), as well as higher rates of anti-basal ganglia antibodies (Khanna et al., 1997a; 1997b).”
BackgroundPassionate love and sexual desire: Multidisciplinary perspectives.
Hatfield, E. C., & Rapson, R. L. (2008) · Cited by 5
Love, Veritably—A Mélange of Love, Intimacy, Attraction, and Sensuality
Das, K., & Rao, T. S. (2022) · Journal of Psychosexual Health · doi:10.1177/26318318221102126 · Cited by 5
Lovesickness: The Most Common Form of Heart Disease
Dzaja, N. (2008) · Cited by 5
Decreased Lymphocyte 3H-Paroxetine Binding in Obsessive-Compulsive Disorder
Marazziti, D., Baroni, S., Másala, I., Giannaccini, G., Mungai, F., Nasso, E. D., & Cassano, G. B. (2003) · Neuropsychobiology · doi:10.1159/000070580 · Cited by 5
Metadata
- Authors
- MARAZZITI, D., AKISKAL, H. S., ROSSI, A., & CASSANO, G. B.
- Affiliations
- University of Pisa (IT)
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 1999-05
- Volume
- 29
- Issue
- 3
- Pages
- 741-745
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2006411360
- Cited by
- 175
- References
- 27
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 7 · 2023: 7 · 2022: 7 · 2021: 7 · 2020: 6 · 2019: 3 · 2018: 7 · 2017: 14 · 2016: 6 · 2015: 6 · 2014: 10 · 2013: 4 · 2012: 15
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Keywords
- platelet serotonin transporter, romantic love, obsessive-compulsive disorder, serotonergic system, overvalued ideas, obsession, neuroticism, sexual behavior, evolution of love
- MeSH terms
- Adult, Binding Sites, Biological Transport, Buffers, Female, Humans, Interpersonal Relations, Love, Male, Obsessive-Compulsive Disorder, Serotonin, Sexual Behavior, Selective Serotonin Reuptake Inhibitors, Paroxetine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
