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Sensitivity amplification in biochemical systems
Abstract
The sensitivity of biological systems to changes in environmental stimuli is connected with their regulatory properties. In order to achieve efficient control, these systems must respond to minute environmental variations by amplifying external stimuli to yield a significant response. To that end, biochemical systems have often evolved to a cascade organization in which the product of the nth reaction in a chain acts as a catalyst in subsequent transformations. The amplification properties of such cascades were first noticed in the process of blood clotting (MacFarlane, 1964, 1969) and visual excitation (Wald, 1965). Later on, a similar organization was noticed in hormonal control of metabolism (Bowness, 1964; Stadtman & Chock, 1977, 1978; Chock, Rhee & Stadtman, 1980).
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Citations
Cited by
Ultrasensitivity in the mitogen-activated protein kinase cascade.
Huang, C. Y., & Ferrell, J. E. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10078 · Cited by 1,186
The Biochemical Basis of an All-or-None Cell Fate Switch in Xenopus Oocytes
Ferrell, J. E., & Machleder, E. M. (1998) · Science · doi:10.1126/science.280.5365.895 · Cited by 1,052
Ferrell, J. E. (1996) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)20026-x · Cited by 591
A minimal cascade model for the mitotic oscillator involving cyclin and cdc2 kinase.
Goldbeter, A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.20.9107 · Cited by 406
Self-citationCancer: A Systems Biology disease
Hornberg, J. J., Bruggeman, F. J., Westerhoff, H. V., & Lankelma, J. (2006) · Biosystems · doi:10.1016/j.biosystems.2005.05.014 · Cited by 381
Metadata
- Authors
- Goldbeter, A., & Koshland, D. E.
- Venue
- Quarterly Reviews of Biophysics
- Publisher
- Cambridge University Press (CUP)
- Published
- 1982-08
- Volume
- 15
- Issue
- 3
- Pages
- 555-591
- ISSN
- 0033-5835 (ISSN-L)
- 1469-8994
- OpenAlex
- W1998318331
- Cited by
- 163
- References
- 0
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- closed
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