The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs
Open accessAbstract
Recent experimental work has shown that the mitogen-activated protein (MAP) kinase cascade can convert graded inputs into switch-like outputs. The cascade could therefore filter out noise (signals of insufficient magnitude or duration) and still respond decisively to supra-threshold stimuli. Here, we explore the biochemical mechanisms likely to be at the root of this behavior.
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Citations
Cites
Ultrasensitivity in the mitogen-activated protein kinase cascade.
Huang, C. Y., & Ferrell, J. E. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10078 · Cited by 1,186
Self-citationGoldbeter, A., & Koshland, D. E. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42619-6 · Cited by 230
Bardwell, L., Cook, J. G., Chang, E. C., Cairns, B. R., & Thorner, J. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.7.3637 · Cited by 161
Cited by
Cell Wall Integrity Signaling in Saccharomyces cerevisiae
Levin, D. E. (2005) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.69.2.262-291.2005 · Cited by 1,136
The Biochemical Basis of an All-or-None Cell Fate Switch in Xenopus Oocytes
Ferrell, J. E., & Machleder, E. M. (1998) · Science · doi:10.1126/science.280.5365.895 · Cited by 1,052
Self-citationMultisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication
Nash, P., Tang, X., Orlicky, S., Chen, Q., Gertler, F. B., Mendenhall, M. D., Sicheri, F., Pawson, T., & Tyers, M. (2001) · Nature · doi:10.1038/35107009 · Cited by 759
Martin, K. C., Michael, D., Rose, J. C., Barad, M., Casadio, A., Zhu, H., & Kandel, E. R. (1997) · Neuron · doi:10.1016/s0896-6273(00)80330-x · Cited by 545
Single-Nucleosome Mapping of Histone Modifications in S. cerevisiae
Liu, C. L., Kaplan, T., Kim, M., Buratowski, S., Schreiber, S. L., Friedman, N., & Rando, O. J. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030328 · Cited by 499
Metadata
- Authors
- Ferrell, J. E.
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 1996-12
- Volume
- 21
- Issue
- 12
- Pages
- 460-466
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W1544401280
- Cited by
- 591
- References
- 3
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ferrell, J. E. (1996). Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs. Trends in Biochemical Sciences. https://doi.org/10.1016/s0968-0004(96)20026-x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
