Amplified selectivity in cognitive processing implements the neural gain model of norepinephrine function
Abstract
Previous work has suggested that an interaction between local selective (e.g., glutamatergic) excitation and global gain modulation (via norepinephrine) amplifies selectivity in information processing. Mather et al. extend this existing theory by suggesting that localized gain modulation may further mediate this effect – an interesting prospect that invites new theoretical and experimental work.
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Correlations between the gain of neural responses and psychophysical performance support the hypothesis that gain modulation may mediate the trade-off between sensitivity to all salient signals and selectivity for specific signals.
“Correlations between the gain of neural responses and psychophysical performance support the hypothesis that gain modulation may mediate the trade-off between sensitivity to all salient signals and selectivity for specific signals25.”
From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [25]
Cites
Aston-Jones, G., & Cohen, J. D. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135709 · Cited by 4,472 · see citing works
Self-citationA Network Model of Catecholamine Effects: Gain, Signal-to-Noise Ratio, and Behavior
Servan‐Schreiber, D., Printz, H., & Cohen, J. D. (1990) · Science · doi:10.1126/science.2392679 · Cited by 770 · see citing works
Self-citationThe role of locus coeruleus in the regulation of cognitive performance
Usher, M., Cohen, J. D., Servan-Schreiber, D., Rajkowski, J., & Aston-Jones, G. (1999) · Science · doi:10.1126/science.283.5401.549 · Cited by 715 · see citing works
Self-citationThe effects of neural gain on attention and learning
Eldar, E., Cohen, J. D., & Niv, Y. (2013) · Nature Neuroscience · doi:10.1038/nn.3428 · Cited by 402 · see citing works
Self-citationWaterhouse, B. D., & Woodward, D. J. (1980) · Experimental Neurology · doi:10.1016/0014-4886(80)90159-4 · Cited by 322 · see citing works
Moises, H. C., Woodward, D. J., Hoffer, B. J., & Freedman, R. (1979) · Experimental Neurology · doi:10.1016/0014-4886(79)90227-9 · Cited by 201 · see citing works
Cortical inputs to m2-immunoreactive striatal interneurons in rat and monkey
Thomas, T. M., Smith, Y., Levey, A. I., & Hersch, S. M. (2000) · Synapse · doi:10.1002/1098-2396(20000915)37:4 · Cited by 81 · see citing works
Marrocco, R. T., Lane, R., McClurkin, J. W., Blaha, C. D., & Alkire, M. T. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-09-02756.1987 · Cited by 46 · see citing works
Do You See the Forest or the Tree? Neural Gain and Breadth Versus Focus in Perceptual Processing
Eldar, E., Niv, Y., & Cohen, J. D. (2016) · Psychological Science · doi:10.1177/0956797616665578 · Cited by 43 · see citing works
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Mechanisms underlying gain modulation in the cortex
Ferguson, K. A., & Cardin, J. A. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0253-y · Cited by 327 · see citing works
- Authors
- Eldar, E., Cohen, J. D., & Niv, Y.
- Affiliations
- Wellcome Centre for Human Neuroimaging (GB)
- Princeton University (US)
- Venue
- Behavioral and Brain Sciences
- Publisher
- Cambridge University Press (CUP)
- Published
- 2016
- Volume
- 39
- Pages
- e206-e206
- ISSN
- 0140-525X (ISSN-L)
- 1469-1825
- OpenAlex
- W2584063163
- Cited by
- 12
- References
- 9
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 1
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral and Brain Sciences (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- norepinephrine, gain modulation, selective attention, glutamatergic excitation, localized excitations, information processing
- MeSH terms
- Cognition, Humans, Models, Theoretical, Norepinephrine
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