The role of locus coeruleus in the regulation of cognitive performance
Abstract
Noradrenergic locus coeruleus (LC) neurons were recorded in monkeys performing a visual discrimination task, and a computational model was developed addressing the role of the LC brain system in cognitive performance. Changes in spontaneous and stimulus-induced patterns of LC activity correlated closely with fluctuations in behavioral performance. The model explains these fluctuations in terms of changes in electrotonic coupling among LC neurons and predicts improved performance during epochs of high coupling and synchronized LC firing. Cross correlations of simultaneously recorded LC neurons confirmed this prediction, indicating that electrotonic coupling in LC may play an important role in attentional modulation and the regulation of goal-directed versus exploratory behaviors.
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The locus coeruleus changes its activity between phasic or tonic modes.
“The LC changes its activity between phasic or tonic modes (Aston-Jones and Cohen, 2005; Usher et al., 1999).”
From Biological rhythms, higher brain function, and behavior: Gaps, opportunities, and challenges (2009) · cites this paper as Usher et al., 1999
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Self-citation
- Authors
- Usher, M., Cohen, J. D., Servan-Schreiber, D., Rajkowski, J., & Aston-Jones, G.
- Affiliations
- University of Pittsburgh (US)
- M. Usher, Department of Psychology, University of Kent, Canterbury, UK. J. D. Cohen, Department of Psychology, Princeton University, Princeton, NJ 08540, USA and Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA. D. Servan-Schreiber, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA. J. Rajkowski and G. Aston-Jones, Department of Psychiatry, University of Pennsylvania, VAMC (151), University and Woodland Avenues, Philadelphia, PA 19104, USA.
- Venue
- Science
- Published
- 1999-01-22
- Volume
- 283
- Issue
- 5401
- Pages
- 549-554
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2057594895
- Cited by
- 715
- References
- 43
- Citations by year
- 2026: 11 · 2025: 23 · 2024: 21 · 2023: 25 · 2022: 22 · 2021: 26 · 2020: 29 · 2019: 34 · 2018: 35 · 2017: 38 · 2016: 32 · 2015: 34 · 2014: 28 · 2013: 20 · 2012: 34
- FWCI
- 12.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Kent Academic Repository (University of Kent) (submittedVersion)
- Funders
- National Institutes of Health (5r01mh055309-05)
- National Institute of Mental Health (MH 45156, MH-47566, MH-55309, P50MH045156, P01MH047566)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- locus coeruleus, noradrenergic neurons, cognitive performance, visual discrimination task, electrical coupling, neuronal synchronization, attentional modulation, goal-directed behavior, exploratory behavior, computational model, spontaneous neuronal activity
- MeSH terms
- Action Potentials, Animals, Behavior, Animal, Cognition, Discrimination, Psychological, Electrophysiology, Locus Coeruleus, Macaca fascicularis, Models, Neurological, Neurons, Norepinephrine, Photic Stimulation, Psychomotor Performance
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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