The DOI matches its Crossref record; 417 of the 417 references it cites were found in a registry or an index.
Episodic memory, amnesia, and the hippocampal–anterior thalamic axis
Abstract
By utilizing new information from both clinical and experimental (lesion, electrophysiological, and gene-activation) studies with animals, the anatomy underlying anterograde amnesia has been reformulated. The distinction between temporal lobe and diencephalic amnesia is of limited value in that a common feature of anterograde amnesia is damage to part of an “extended hippocampal system” comprising the hippocampus, the fornix, the mamillary bodies, and the anterior thalamic nuclei. This view, which can be traced back to Delay and Brion (1969), differs from other recent models in placing critical importance on the efferents from the hippocampus via the fornix to the diencephalon. These are necessary for the encoding and, hence, the effective subsequent recall of episodic memory. An additional feature of this hippocampal–anterior thalamic axis is the presence of projections back from the diencephalon to the temporal cortex and hippocampus that also support episodic memory. In contrast, this hippocampal system is not required for tests of item recognition that primarily tax familiarity judgements. Familiarity judgements reflect an independent process that depends on a distinct system involving the perirhinal cortex of the temporal lobe and the medial dorsal nucleus of the thalamus. In the large majority of amnesic cases both the hippocampal–anterior thalamic and the perirhinal–medial dorsal thalamic systems are compromised, leading to severe deficits in both recall and recognition.
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“Furthermore, damage to the fornix, as well as the anterior thalamus, causes anterograde amnesia in humans (Aggleton and Brown, 1999; Aggleton et al., 2000; Carlesimo et al., 2011; Gaffan and Gaffan, 1991).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Aggleton and Brown, 1999
In the citing paper
“the anterior thalamic nuclei are seen as critical components of the pathology responsible for diencephalic amnesia (Aggleton and Brown, 1999; Carlesimo et al., 2011).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Aggleton and Brown, 1999
In the citing paper
“This separation is true of other amnesic patients, especially those resulting from hippocampal damage, whereby semantic memory largely remains intact but severe deficits in episodic memory are observed [6–9].”
From Is episodic-like memory like episodic memory? (2024) · cites this paper as [9]
Citations
Cites
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Tulving, E. (2002) · Annual Review of Psychology · doi:10.1146/annurev.psych.53.100901.135114 · Cited by 4,950
The Medial Temporal Lobe and Recognition Memory
Eichenbaum, H., Yonelinas, A. P., & Ranganath, C. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094328 · Cited by 2,580
The human hippocampus and spatial and episodic memory
Burgess, N., Maguire, E. A., & O'Keefe, J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00830-9 · Cited by 2,401
Neurobiology of emotion perception I: the neural basis of normal emotion perception
Phillips, M. L., Drevets, W. C., Rauch, S. L., & Lane, R. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00168-9 · Cited by 2,173
The evolution of foresight: What is mental time travel, and is it unique to humans?
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Metadata
- Authors
- Aggleton, J. P., & Brown, M. W.
- Affiliations
- Cardiff University (GB)
- University of Bristol (GB)
- ORCID
- Aggleton, John P.
- Venue
- Behavioral and Brain Sciences
- Publisher
- Cambridge University Press (CUP)
- Published
- 1999-06
- Volume
- 22
- Issue
- 3
- Pages
- 425-444
- ISSN
- 0140-525X (ISSN-L)
- 1469-1825
- OpenAlex
- W2154521931
- Cited by
- 1,879
- References
- 417
- Citations by year
- 2026: 22 · 2025: 37 · 2024: 35 · 2023: 40 · 2022: 52 · 2021: 74 · 2020: 63 · 2019: 55 · 2018: 68 · 2017: 62 · 2016: 65 · 2015: 84 · 2014: 69 · 2013: 79 · 2012: 90
- FWCI
- 38.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral and Brain Sciences (publishedVersion)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- episodic memory, anterograde amnesia, hippocampus, anterior thalamic nuclei, fornix, mammillary bodies, diencephalon, familiarity, recognition memory, perirhinal cortex
- MeSH terms
- Amnesia, Hippocampus, Humans, Memory, Short-Term, Models, Neurological, Neural Pathways, Mental Recall, Temporal Lobe, Thalamus, Anterior Thalamic Nuclei, Midline Thalamic Nuclei, Fornix, Brain, Recognition, Psychology
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