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Cited by 9

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Effects of Creatine and Exercise on Skeletal Muscle of FRG1-Transgenic Mice

Ogborn, Daniel I., Smith, Katelyn J., Crane, Justin D., Safdar, Adeel, Hettinga, Bart P., Tupler, Rossella, Tarnopolsky, Mark A.·2012·Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
DOI 10.1017/s0317167100013275
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Abstract

Background: The FRG1-transgenic mouse displays muscle dysfunction and atrophy reminiscent of fascioscapulohumeral muscular dystrophy (FSHD) and could provide a model to determine potential therapeutic interventions. Methods: To determine if FRG1 mice benefit from treatments that improve muscle mass and function, mice were treated with creatine alone (Cr) or in combination with treadmill exercise (CrEX). Results: The CrEx treatment increased quadriceps weight, mitochondrial content (cytochome c oxidase (COX) activity, COX subunit one and four protein), and induced greater improvements in grip strength and rotarod fall speed. While Cr increased COX subunits one and four protein, no effect on muscle mass or performance was found. Since Cr resulted in no functional improvements, the benefits of CrEx may be mediated by exercise; however, the potential synergistic action of the combined treatment cannot be excluded. Conclusion: Treatment with CrEx attenuates atrophy and muscle dysfunction associated with FRG1 overexpression. These data suggest exercise and creatine supplementation may benefit individuals with FSHD.

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Metadata

Authors
Ogborn, D. I., Smith, K. J., Crane, J. D., Safdar, A., Hettinga, B. P., Tupler, R., & Tarnopolsky, M. A.
Venue
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
Publisher
Cambridge University Press (CUP)
Published
2012-03
Volume
39
Issue
2
Pages
225-231
ISSN
  • 0317-1671
  • 2057-0155
DOI
10.1017/s0317167100013275
Cited by
9
References
7
Language
en
Licence
www.cambridge.org/core/terms (unspecified, 1006 d)

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CoChat. (2026). Citation check: Effects of Creatine and Exercise on Skeletal Muscle of FRG1-Transgenic Mice. https://app.cochat.ai/papers/10.1017/s0317167100013275
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Ogborn, D. I., Smith, K. J., Crane, J. D., Safdar, A., Hettinga, B. P., Tupler, R., & Tarnopolsky, M. A. (2012). Effects of Creatine and Exercise on Skeletal Muscle of FRG1-Transgenic Mice. Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. https://doi.org/10.1017/s0317167100013275

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.