Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation

On the origin of cancer cells

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STATs: transcriptional control and biological impact

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Stat3 as an Oncogene

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Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

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JAK-STAT Signaling: From Interferons to Cytokines

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Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

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Function of Mitochondrial Stat3 in Cellular Respiration

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Enhanced DNA-Binding Activity of a Stat3-Related Protein in Cells Transformed by the Src Oncoprotein

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What does Stat3 do?

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Association of Transcription Factor APRF and Protein Kinase Jak1 with the Interleukin-6 Signal Transducer gp130

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What does Stat3 do?

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Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change

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Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas

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Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target

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Signaling Interplay in Ras Superfamily Function

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Tracking STAT nuclear traffic

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A Gene Specifying Subunit VIII of Human Cytochrome c Oxidase Is Localized to Chromosome 11 and Is Expressed in Both Muscle and Non-muscle Tissues

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Acute phase response factor and additional members of the interferon-stimulated gene factor 3 family integrate diverse signals from cytokines, interferons, and growth factors.

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Fluorescence protease protection of GFP chimeras to reveal protein topology and subcellular localization

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Paradigm shifts in the cell biology of STAT signaling

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New and Old Functions of STAT3: A Pivitol Target for Individualized Treatment of Cancer

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Malignant Transformation but not Normal Cell Growth Depends on Signal Transducer and Activator of Transcription 3

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Touched and Moved by STAT3

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Ras/ERK1/2-mediated STAT3 Ser727 Phosphorylation by Familial Medullary Thyroid Carcinoma-associated RET Mutants Induces Full Activation of STAT3 and Is Required for c-fos Promoter Activation, Cell Mitogenicity, and Transformation

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Transcriptional control of effector and memory CD8+ T cell differentiation

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Mechanisms and consequences of Jak–STAT signaling in the immune system

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A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo

Bai, L., Zhou, H., Xu, R., Zhao, Y., Chinnaswamy, K., McEachern, D., Chen, J., Yang, C.-Y., Liu, Z., Wang, M., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.10.002 · Cited by 652 · see citing works

Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

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Metabolic switching and fuel choice during T‐cell differentiation and memory development

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Choosing between glycolysis and oxidative phosphorylation: a tumor’s dilemma?

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JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia

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AZD9150, a next-generation antisense oligonucleotide inhibitor of <i>STAT3</i> with early evidence of clinical activity in lymphoma and lung cancer

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<i>STAT3</i> Plays a Critical Role in <i>KRAS</i> -Induced Pancreatic Tumorigenesis

Corcoran, R. B., Contino, G., Deshpande, V., Tzatsos, A., Conrad, C., Benes, C. H., Levy, D. E., Settleman, J., Engelman, J. A., & Bardeesy, N. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-0908 · Cited by 413 · see citing works

Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution

Bharadwaj, U., Kasembeli, M. M., Robinson, P., & Tweardy, D. J. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018440 · Cited by 314 · see citing works

Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions

Liou, G.-Y., Döppler, H., DelGiorno, K. E., Zhang, L., Leitges, M., Crawford, H. C., Murphy, M. P., & Storz, P. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.029 · Cited by 270 · see citing works

IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine ‘Bystander senescence’

Hubackova, S., Krejcikova, K., Bartek, J., & Hodny, Z. (2012) · Aging · doi:10.18632/aging.100520 · Cited by 272 · see citing works

Parvalbumin interneuron vulnerability and brain disorders

Ruden, J. B., Dugan, L. L., & Konradi, C. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-020-0778-9 · Cited by 194 · see citing works

Molecular intricacies of aerobic glycolysis in cancer: Current insights into the classic metabolic phenotype

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Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation

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3D scaffolds in breast cancer research

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IL-6-STAT3 signaling and premature senescence

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The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia

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Emerging concepts in bioenergetics and cancer research: metabolic flexibility, coupling, symbiosis, switch, oxidative tumors, metabolic remodeling, signaling and bioenergetic therapy

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Protein acetylation and deacetylation: An important regulatory modification in gene transcription (Review)

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Cytoprotection by the modulation of mitochondrial electron transport chain: The emerging role of mitochondrial STAT3

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Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells

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Anticancer Drugs Targeting the Mitochondrial Electron Transport Chain

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STAT3 in hepatocellular carcinoma: new perspectives

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Nuclear-encoded mitochondrial proteins and their role in cardioprotection

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Circumventing senescence is associated with stem cell properties and metformin sensitivity

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Setting the Tone: Reactive Oxygen Species and the Control of Appetitive Melanocortin Neurons

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The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies

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Signal transducers and activators of transcription 3 signaling pathway in the pathogenesis and treatment of psoriasis

Wei, J. (2013) · Yixue yanjiusheng xuebao

Signal transducer and activator of transcription (STAT) signalling and T‐cell lymphomas

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Effect of signal transducer and activator of transcription 3 in neoplasms invasion and metastasis

Huang, H. (2010) · International Journal of Stomatology

Effects of Signal Transducer and Activator of Transcription 3 on the Tumorigenesis

Ma, X. (2009) · Letters in Biotechnology