Add-on trial of clobazam in intractable adult epilepsy with plasma level correlations
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Clobazam, a novel benzodiazepine, was used as an add-on agent in 47 adult patients with intractable epilepsy and a variety of seizure types. A >75% reduction in seizure frequency was observed in 42% (18) of the patients and a >50% reduction in 65% (29) of the patients which was sustained over a mean follow-up period of 13.3 (±5.6) months. Nine patients had to discontinue the drug due to minor adverse effects or increased seizures. Possible tolerance developed in 6 patients. Plasma levels of the active metabolite N-desmethylclobazam were linearly related to dosage and appeared to correlate with both therapeutic and toxic responses. Clobazam appears to be a safe and effective add-on antiepileptic for a wide variety of seizure types in intractable epilepsy.
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Up to 25% of patients may remain seizure free while taking adjunctive clobazam for long periods.
“However, a portion of patients (up to 25%) may remain seizure free while taking adjunctive clobazam for long periods (141-144).”
From Benzodiazepines in epilepsy: Pharmacology and pharmacokinetics (2008) · cites this paper as [142]
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- Authors
- Guberman, A., Couture, M., Blaschuk, K., & Sherwin, A.
- Affiliations
- Ottawa Hospital (CA)
- Montreal Neurological Institute and Hospital (CA)
- Corresponding author
- Guberman, A.
- Venue
- Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
- Publisher
- Cambridge University Press (CUP)
- Published
- 1990-08
- Volume
- 17
- Issue
- 3
- Pages
- 311-316
- ISSN
- 0317-1671 (ISSN-L)
- 2057-0155
- OpenAlex
- W2405549230
- Cited by
- 40
- References
- 16
- Citations by year
- 2026: 1 · 2018: 1 · 2017: 1 · 2015: 1 · 2013: 1 · 2012: 3
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Keywords
- clobazam, drug-resistant epilepsy, adjunctive antiepileptic therapy, benzodiazepines, N-desmethylclobazam, plasma drug concentration, seizure frequency reduction, adverse drug reactions, drug tolerance, pharmacokinetics
- MeSH terms
- Clobazam, Adult, Aged, Anticonvulsants, Benzodiazepines, Benzodiazepinones, Dose-Response Relationship, Drug, Epilepsy, Humans, Middle Aged, Seizures, Anti-Anxiety Agents
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