The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
On the Use of Tranquillisers in Epilepsy
Open accessAbstract
Summary: In this article, the use of benzodiazepines (BZDs) in epilepsy is reviewed. In particular, it concentrates on the use of oral BZDs, and, following a brief discussion as to their value in psychiatric disorders generally, their more specific use in epilepsy is then noted. The main oral drugs are the 1,4BZDs and 1,5‐BZDs. The latter is represented only by clobazam (CLB), and the advantages of the 1,5‐BZDs over the 1,4‐BZDs are reviewed. It is concluded that CLB has a significant value in a number of situations. It is a first‐line add‐on therapy when standard medications have failed. It is useful in patients that have catamenial seizures, clusters of seizures, and also in the prevention of postictal syndromes. It is used in childhood epilepsy, and is also helpful in the management of febrile seizures.
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Clonazepam is used primarily as adjunctive therapy for patients with treatment-resistant primary and secondarily generalized seizures.
“Clonazepam is used primarily as an adjunctive therapy to treat patients with a wide range of treatment-resistant primary and secondarily generalized seizures (103).”
From Benzodiazepines in epilepsy: Pharmacology and pharmacokinetics (2008) · cites this paper as [103]
Clobazam is not approved in the USA but is commonly used elsewhere as adjunctive therapy for refractory epilepsy.
“Although not currently approved in the USA, clobazam is commonly used elsewhere as adjunctive therapy for patients with refractory epilepsy (103).”
From Benzodiazepines in epilepsy: Pharmacology and pharmacokinetics (2008) · cites this paper as [103]
Clinical experience and available data are less extensive for clorazepate than for other benzodiazepines.
“The effectiveness of adjunctive clorazepate for various treatment-resistant seizures has been demonstrated; however, the clinical experience and data available are less extensive for clorazepate than for other BZDs ( 103).”
From Benzodiazepines in epilepsy: Pharmacology and pharmacokinetics (2008) · cites this paper as [103]
The effectiveness of adjunctive clorazepate for various treatment-resistant seizures has been demonstrated.
“The effectiveness of adjunctive clorazepate for various treatment-resistant seizures has been demonstrated; however, the clinical experience and data available are less extensive for clorazepate than for other BZDs ( 103).”
From Benzodiazepines in epilepsy: Pharmacology and pharmacokinetics (2008) · cites this paper as [103]
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Citations
Cites
Epilepsy: A Comprehensive Textbook
(2008) · JAMA · doi:10.1001/jama.300.4.443-a · Cited by 2,357
Epilepsy: A Comprehensive Textbook
(1998) · Archives of Neurology · doi:10.1001/archneur.55.10.1373 · Cited by 455
Antiepileptic Properties of Clobazam, a 1–5 Benzodiazepine, in Man
Gastaut, H., & Low, M. D. (1979) · Epilepsia · doi:10.1111/j.1528-1157.1979.tb04825.x · Cited by 144
Koch-Weser, J., & Browne, T. R. (1978) · New England Journal of Medicine · doi:10.1056/nejm197810122991505 · Cited by 106
Clobazam in Treatment of Refractory Epilepsy: The Canadian Experience. A Retrospecti
(1991) · Epilepsia · doi:10.1111/j.1528-1157.1991.tb04670.x · Cited by 102
Add-on trial of clobazam in intractable adult epilepsy with plasma level correlations
Guberman, A., Couture, M., Blaschuk, K., & Sherwin, A. (1990) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s031716710003064x · Cited by 40
Factors relating to dramatic response to clobazam therapy in refractory epilepsy
Heller, A. J., Ring, H. A., & Reynolds, E. H. (1988) · Epilepsy Research · doi:10.1016/0920-1211(88)90020-4 · Cited by 27
The place of clobazam in the treatment of epilepsy: An update
Robertson, M. M. (1995) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.470100705 · Cited by 11
Adjunctive therapy with benzodiazepines
Guberman, A. H. (1995) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.470100711 · Cited by 1
Flagged first, then by citations
Research works printed but not linked: 4
- Allgulander C, 2000, Benzodiazepines, 147
- Walker MC, 2000, Benzodiazepines, 73
- Wolf P, 1985, Clobazam, 167
- Feely M, 2000, Benzodiazepines, 111
Cited by
Sorted by citations
Benzodiazepines in epilepsy: Pharmacology and pharmacokinetics
Riss, J., Cloyd, J., Gates, J., & Collins, S. (2008) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2008.01004.x · Cited by 511
Metadata
- Authors
- Trimble, M. R.
- Affiliations
- National Hospital for Neurology and Neurosurgery (GB)
- Corresponding author
- Trimble, Michael R.
- ORCID
- Trimble, Michael R.
- Venue
- Epilepsia
- Publisher
- Wiley
- Published
- 2002-02
- Volume
- 43
- Issue
- s2
- Pages
- 25-27
- ISSN
- 0013-9580 (ISSN-L)
- 1528-1167
- OpenAlex
- W1987148457
- Cited by
- 16
- References
- 9
- Citations by year
- 2016: 1 · 2015: 1 · 2012: 1
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Epilepsia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
- Keywords
- benzodiazepines, epilepsy, clobazam, 1,5-benzodiazepines, 1,4-benzodiazepines, adjunctive therapy, seizure clusters, pediatric epilepsy, febrile seizures, mental illness
- MeSH terms
- Clobazam, Anticonvulsants, Benzodiazepines, Epilepsy, Humans, Tranquilizing Agents, Anti-Anxiety Agents
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