Clobazam as an add-on drug in the treatment of refractory epilepsy of childhood
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We report the results of a double-blind cross-over study comparing clobazam and placebo in the treatment of refractory childhood epilepsy. Fifty-two percent of patients had greater than 50% reduction in their seizure frequency when taking the clobazam. During the placebo phase no patient recorded a greater than 50% reduction in seizure frequency. Sex, age, seizure type, intellect did not appear to differentiate clobazam responsive from nonresponsive patients. Only 2/21 patients had behavioral changes on the drug sufficiently severe to require the patient to drop out of the study prematurely. Drug interactions between clobazam and the other anticonvulsant medicines did not occur.
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In several double-blind, placebo-controlled, add-on trials in patients with refractory epilepsy, adjunctive clobazam was effective.
“In several double-blind, placebo-controlled, add-on trials in patients with refractory epilepsy, adjunctive clobazam was shown to be effective (17,(145)(146)(147)(148)(149)(150)(151)(152).”
From Benzodiazepines in epilepsy: Pharmacology and pharmacokinetics (2008) · cites this paper as [145]
In a crossover study of 21 patients, more than 50% reduction in seizure frequency occurred in 52% of patients receiving clobazam.
“In a crossover study of 21 patients, a >50% reduction in seizure frequency was seen in 52% of patients receiving clobazam (145).”
From Benzodiazepines in epilepsy: Pharmacology and pharmacokinetics (2008) · cites this paper as [145]
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Cites
Antiepileptic Properties of Clobazam, a 1–5 Benzodiazepine, in Man
Gastaut, H., & Low, M. D. (1979) · Epilepsia · doi:10.1111/j.1528-1157.1979.tb04825.x · Cited by 144 · see citing works
Benzodiazepines in the Treatment of Children with Epilepsy
Farrello, K. (1986) · Epilepsia · doi:10.1111/j.1528-1157.1986.tb05733.x · Cited by 75 · see citing works
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Research works printed but not linked: 3
- Gastaut H. The effects of benzodiazepines on chronic epilepsy in man (with particular reference to clobazam). In: Hindmarch 1, Stonier PD, eds. Clobazam International Congress and Sym- posium Series. London: Royal Society of Medicine 1981; 43: 141-446.
- Koeppen D. A review of clobazam studies in epilepsy. In: Hindmarch I, Stonier PD, Trimble MR, eds. Clobazam: Human Psychopharmacology and Clinical Applications. International Congress and Symposium Series, London: Royal Society of Medi- cine 1985; 74: 159-165.
- Guberman H, Sherwin A, Blaschuk K. Add-on trial of clobazam in 36 intractable epileptic patients, with plasma level correla- tions. Can J Neurol Sci 1989; 16: 248 (Abst).
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Guerrini, R. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68182-8 · Cited by 848 · see citing works
Benzodiazepines in epilepsy: Pharmacology and pharmacokinetics
Riss, J., Cloyd, J., Gates, J., & Collins, S. (2008) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2008.01004.x · Cited by 511 · see citing works
The use of clobazam, midazolam, and nitrazepam in epilepsy
Shorvon, S. D. (1998) · Epilepsia · doi:10.1111/j.1528-1157.1998.tb05109.x · Cited by 27 · see citing works
- Authors
- Keene, D. L., Whiting, S., & Humphreys, P.
- Affiliations
- Children's Hospital of Eastern Ontario (CA)
- Corresponding author
- Keene, D.L.
- Venue
- Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
- Publisher
- Cambridge University Press (CUP)
- Published
- 1990-08
- Volume
- 17
- Issue
- 3
- Pages
- 317-319
- ISSN
- 0317-1671 (ISSN-L)
- 2057-0155
- OpenAlex
- W2405407945
- Cited by
- 52
- References
- 2
- Citations by year
- 2026: 2 · 2024: 3 · 2023: 1 · 2022: 1 · 2019: 2 · 2018: 1 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 4
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Keywords
- clobazam, drug-resistant epilepsy, pediatric epilepsy, adjunctive therapy, seizure frequency reduction, benzodiazepines, anticonvulsant drug interactions
- MeSH terms
- Clobazam, Adolescent, Benzodiazepines, Benzodiazepinones, Child, Child, Preschool, Double-Blind Method, Drug Resistance, Drug Therapy, Combination, Epilepsy, Female, Humans, Infant, Infant, Newborn, Male, Anti-Anxiety Agents
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