Epilepsy in children

Guerrini, Renzo

doi:10.1016/s0140-6736(06)68182-8

Cited by 850Epilepsy research and treatmentPharmacological Effects and Toxicity StudiesDiet and metabolism studies

Epilepsy in children

Guerrini, Renzo·2006·The Lancet

DOI 10.1016/s0140-6736(06)68182-8

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Abstract

10.5 million children worldwide are estimated to have active epilepsy. Over the past 15 years, syndrome-oriented clinical and EEG diagnosis, and better aetiological diagnosis, especially supported by neuroimaging, has helped to clarify the diversity of epilepsy in children, and has improved management. Perinatal and postinfective encephalopathy, cortical dysplasia, and hippocampal sclerosis account for the most severe symptomatic epilepsies. Ion channel defects can underlie both benign age-related disorders and severe epileptic encephalopathies with a progressive disturbance in cerebral function. However, the reasons for age-related expression in children are not understood. Neither are the mechanisms whereby an epileptic encephalopathy originates. Several new drugs have been recently introduced but have provided limited therapeutic benefits. However, treatment and quality of life have improved because the syndrome-specific efficacy profile of drugs is better known, and there is heightened awareness that compounds with severe cognitive side-effects and heavy polytherapies should be avoided. Epilepsy surgery is an important option for a few well-selected individuals, but should be considered with great caution when there is no apparent underlying brain lesion.

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Simply adopting a protocol reduces mortality and morbidity, although there is little evidence to show that one of the numerous recommended protocols is better than another.
“This is a delicate matter, as simply adopting a protocol reduces mortality and morbidity, although there is little evidence to show that one of the numerous recommended protocols is better than another 211 .”
From Developmental and epileptic encephalopathies (2024) · cites this paper as [211]

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Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy: Initial monotherapy outcomes at 12 months
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Role of Brain Inflammation in Epileptogenesis
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Epilepsy: A Spectrum DisorderPreprint
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Hypothalamic Hamartoma and Seizures: A Treatable Epileptic Encephalopathy
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Diagnostic Targeted Resequencing in 349 Patients with Drug-Resistant Pediatric Epilepsies Identifies Causative Mutations in 30 Different Genes
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Malformations of Cortical Development and EpilepsyPreprint
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Evolving networks in the human epileptic brain
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Peripherally derived T regulatory and γδ T cells have opposing roles in the pathogenesis of intractable pediatric epilepsy
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Authors: Guerrini, R.
Affiliations: University of Pisa (IT)
Corresponding author: Guerrini, Renzo
ORCID: Guerrini, Renzo
Venue: The Lancet
Publisher: Elsevier BV
Published: 2006-02
Volume: 367
Issue: 9509
Pages: 499-524
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(06)68182-8
OpenAlex: W2047243927
Cited by: 848
References: 321
Citations by year: 2026: 15 · 2025: 29 · 2024: 30 · 2023: 27 · 2022: 33 · 2021: 33 · 2020: 21 · 2019: 22 · 2018: 19 · 2017: 20 · 2016: 17 · 2015: 28 · 2014: 26 · 2013: 31 · 2012: 33
FWCI: 4.79
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Florence Research (University of Florence) (submittedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
Health Sciences › Medicine › Physiology › Diet and metabolism studies
Keywords: pediatric epilepsy, epileptic encephalopathy, perinatal encephalopathy, cortical dysplasia, hippocampal sclerosis, ion channel disorders, benign rolandic epilepsy, antiepileptic drugs, epilepsy surgery, etiology, neuroimaging, EEG diagnosis, cognitive side effects
MeSH terms: Adolescent, Anticonvulsants, Child, Child, Preschool, Epilepsy, Humans, Infant, Infant, Newborn, Prognosis

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