The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
3-Nitropropionic Acid - Exogenous Animal Neurotoxin and Possible Human Striatal Toxin
Open accessAbstract
3-Nitropropionic acid (3-NPA) — a suicide inhibitor of succinate dehydrogenase — is a widely distributed plant and fungal neurotoxin known to induce damage to basal ganglia, hippocampus, spinal tracts and peripheral nerves in animals. Recent reports from Northern China indicate that 3-NPA is also likely to be responsible for the development of putaminal necrosis with delayed dystonia in children after ingestion of mildewed sugar cane. This article discusses the role of 3-NPA in the causation of the disease in China, its neurotoxic effects in animals and the potential role for this compound as a probe of selective neuronal vulnerability.
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Cites
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Ageing and neuronal vulnerability
Mattson, M. P., & Magnus, T. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1886 · Cited by 957
Mitochondrial Dysfunction in Neurodegenerative Diseases
Johri, A., & Beal, M. F. (2012) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.192138 · Cited by 806
Mitochondrial defect in Huntington's disease caudate nucleus
Gu, M., Gash, M. T., Mann, V. M., Javoy‐Agid, F., Cooper, J. M., & Schapira, A. H. V. (1996) · Annals of Neurology · doi:10.1002/ana.410390317 · Cited by 758
The Role of Excitotoxicity in Neurodegenerative Disease
Doble, A. (1999) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(98)00042-4 · Cited by 723
Oxidative stress in Huntington’s disease
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Metadata
- Authors
- Ludolph, A. C., He, F., Spencer, P. S., Hammerstad, J., & Sabri, M.
- Venue
- Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
- Publisher
- Cambridge University Press (CUP)
- Published
- 1991-11
- Volume
- 18
- Issue
- 4
- Pages
- 492-498
- ISSN
- 0317-1671 (ISSN-L)
- 2057-0155
- OpenAlex
- W964655
- Cited by
- 485
- References
- 23
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: 3-Nitropropionic Acid - Exogenous Animal Neurotoxin and Possible Human Striatal Toxin. https://app.cochat.ai/papers/10.1017/s0317167100032212
- The paper
- Ludolph, A. C., He, F., Spencer, P. S., Hammerstad, J., & Sabri, M. (1991). 3-Nitropropionic Acid - Exogenous Animal Neurotoxin and Possible Human Striatal Toxin. Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. https://doi.org/10.1017/s0317167100032212
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
