The DOI matches its Crossref record; 146 of the 146 references it cites were found in a registry or an index.
Critical periods in amblyopia
Abstract
The shift in ocular dominance (OD) of binocular neurons induced by monocular deprivation is the canonical model of synaptic plasticity confined to a postnatal critical period. Developmental constraints on this plasticity not only lend stability to the mature visual cortical circuitry but also impede the ability to recover from amblyopia beyond an early window. Advances with mouse models utilizing the power of molecular, genetic, and imaging tools are beginning to unravel the circuit, cellular, and molecular mechanisms controlling the onset and closure of the critical periods of plasticity in the primary visual cortex (V1). Emerging evidence suggests that mechanisms enabling plasticity in juveniles are not simply lost with age but rather that plasticity is actively constrained by the developmental up-regulation of molecular ‘brakes’. Lifting these brakes enhances plasticity in the adult visual cortex, and can be harnessed to promote recovery from amblyopia. The reactivation of plasticity by experimental manipulations has revised the idea that robust OD plasticity is limited to early postnatal development. Here, we discuss recent insights into the neurobiology of the initiation and termination of critical periods and how our increasingly mechanistic understanding of these processes can be leveraged toward improved clinical treatment of adult amblyopia.
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“For some behaviors there are “critical” periods in behavioral development during which individuals are more receptive to environmental influence (72), and such periods may coincide with critical periods in morphological development such as expansion of particular brain regions.”
From Behavior-related gene regulatory networks: A new level of organization in the brain (2020) · cites this paper as [72]
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Research works printed but not linked: 1
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Cited by
Psychedelics reopen the social reward learning critical period
Nardou, R., Sawyer, E., Song, Y. J., Wilkinson, M., Padovan-Hernandez, Y., de Deus, J. L., Wright, N., Lama, C., Faltin, S., Goff, L. A., et al. (2023) · Nature · doi:10.1038/s41586-023-06204-3 · Cited by 358
Wingert, J. C., & Sorg, B. A. (2021) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.673210 · Cited by 129
Gomes, F. V., Zhu, X., & Grace, A. A. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0514-1 · Cited by 91
Psychedelics and Neural Plasticity: Therapeutic Implications
Grieco, S. F., Castrén, E., Knudsen, G. M., Kwan, A. C., Olson, D. E., Zuo, Y., Holmes, T. C., & Xu, X. (2022) · The Journal of Neuroscience · doi:10.1523/jneurosci.1121-22.2022 · Cited by 82
“…et al., 2007; Maya Vetencourt et al., 2008; Baroncelli et al., 2010; Montey et al., 2013; Kaneko and Stryker, 2014; Eaton et al., 2016; Greifzu et al., 2016; Gu et al., 2016; Hensch and Quinlan, 2018; Umemori et al., 2018; Steinzeig et al., 2019; Casarotto et al., 2021; Lesnikova et al., 2021).”
Behavior-related gene regulatory networks: A new level of organization in the brain
Sinha, S., Jones, B. M., Traniello, I. M., Bukhari, S. A., Halfon, M. S., Hofmann, H. A., Huang, S., Katz, P. S., Keagy, J., Lynch, V. J., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1921625117 · Cited by 85
Metadata
- Authors
- HENSCH, T. K., & QUINLAN, E. M.
- Venue
- Visual Neuroscience
- Publisher
- Maximum Academic Press
- Published
- 2018
- Volume
- 35
- ISSN
- 0952-5238
- 1469-8714
- PMC
- PMC6047524
- Cited by
- 206
- References
- 146
- Language
- en
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