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Cited by 117Child and Adolescent Psychosocial and Emotional DevelopmentNeural and Behavioral Psychology StudiesAutism Spectrum Disorder Research

Neurodevelopmental processes in the ontogenesis and epigenesis of psychopathology

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CICCHETTI, DANTE, CANNON, TYRONE D.·1999·Development and Psychopathology
DOI 10.1017/s0954579499002114
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Abstract

Dramatic gains in knowledge have been made in the fields of neuroscience, human development, and developmental psychopathology during the past quarter of a century. Despite the advances that have been achieved in each discipline separately, considerably less progress has occurred in understanding the relation between neurobiological and behavioral development in normal and atypical populations. Research has increasingly demonstrated that abnormalities that occur early in development may result in the emergence of aberrant neural circuitry that eventuates in relatively enduring forms of psychopathology. Knowledge of normal neurobiological development provides a powerful foundation for understanding the contributions that neurodevelopmental processes make to the etiology and sequelae of psychopathology across the life course. An integrated perspective wherein an appreciation of the complex neural, psychological, and social-contextual processes that cohere to bring about normal and pathological outcomes is necessary in order to advance understanding of the genesis and epigenesis of mental disorders. Such an approach will require a reduction of the schisms that so often separate neurobiological and behavioral research.

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Authors
CICCHETTI, D., & CANNON, T. D.
Affiliations
  • University of Rochester (US)
  • University of California, Los Angeles (US)
ORCID
Venue
Development and Psychopathology
Publisher
Cambridge University Press (CUP)
Published
1999-09
Volume
11
Issue
3
Pages
375-393
ISSN
  • 0954-5794 (ISSN-L)
  • 1469-2198
DOI
10.1017/s0954579499002114
OpenAlex
W2108455297
Cited by
117
References
1
Citations by year
2026: 1 · 2024: 1 · 2023: 4 · 2022: 1 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 5 · 2016: 6 · 2015: 12 · 2014: 2 · 2013: 4 · 2012: 6
FWCI
1.64
Type
journal article
Language
en
Open access
Licence
www.cambridge.org/core/terms (unspecified)
Locations
  • Development and Psychopathology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • March of Dimes Foundation
  • National Alliance for Research on Schizophrenia and Depression
  • National Institute of Mental Health (MH-52857, MH54643, R01MH054643, R01MH052857)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Keywords
brain development, developmental psychopathology, ontogeny, epigenesis, life course, mental illness
MeSH terms
Aging, Mental Disorders, Brain, Child, Child Development, Humans

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