Childhood maltreatment is associated with altered frontolimbic neurobiological activity during wakefulness in adulthood

Insana, Salvatore P.; Banihashemi, Layla; Herringa, Ryan J.; Kolko, David J.; Germain, Anne

doi:10.1017/s0954579415000589

Cited by 27Child Abuse and TraumaChild Welfare and AdoptionStress Responses and Cortisol

Childhood maltreatment is associated with altered frontolimbic neurobiological activity during wakefulness in adulthood

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Insana, Salvatore P., Banihashemi, Layla, Herringa, Ryan J., Kolko, David J., Germain, Anne·2016·Development and Psychopathology

DOI 10.1017/s0954579415000589PMC PMC4723293

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Abstract

Childhood maltreatment can disturb brain development and subsequently lead to adverse socioemotional and mental health problems across the life span. The long-term association between childhood maltreatment and resting–wake brain activity during adulthood is unknown and was examined in the current study. Forty-one medically stable and medication-free military veterans (M = 29.31 ± 6.01 years, 78% male) completed a battery of clinical assessments and had [18 F]-fluorodeoxyglucose positron emission tomography neuroimaging scans during quiet wakefulness. After statistically adjusting for later-life trauma and mental health problems, childhood maltreatment was negatively associated with brain activity within a priori defined regions that included the left orbital frontal cortex and left hippocampus. Childhood maltreatment was significantly associated with increased and decreased brain activity within six additional whole-brain clusters that included the frontal, parietal–temporal, cerebellar, limbic, and midbrain regions. Childhood maltreatment is associated with altered neural activity in adulthood within regions that are involved in executive functioning and cognitive control, socioemotional processes, autonomic functions, and sleep/wake regulation. This study provides support for taking a life span developmental approach to understanding the effects of early-life maltreatment on later-life neurobiology, socioemotional functioning, and mental health.

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ELS/CT is associated with altered frontolimbic adult neural activity in the left orbital frontal cortex and left hippocampus.
“Accordingly, in a human resting activity neuroimaging PET study by Insana et al. (423), ELS/CT was associated with altered frontolimbic adult neural activity in the left orbital frontal cortex and left hippocampus, regions involved in executive functioning and emotional autoregulation, socioemotional processes, autonomic function, and”
From Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation (2019) · cites this paper as [423]

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Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation
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“(423), ELS/CT was associated with altered frontolimbic adult neural activity in the left orbital frontal cortex and left hippocampus, regions involved in executive functioning and emotional autoregulation, socioemotional processes, autonomic function, and sleep/wake regulation.”
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Socioemotional wealth preservation in family firms
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Authors: Insana, S. P., Banihashemi, L., Herringa, R. J., Kolko, D. J., & Germain, A.
Affiliations: University of Pittsburgh (US)
University of Wisconsin–Madison (US)
Corresponding author: Germain, Anne
ORCID: Banihashemi, Layla
Herringa, Ryan J.
Kolko, David J.
Germain, Anne
Venue: Development and Psychopathology
Publisher: Cambridge University Press (CUP)
Published: 2015-07-22
Volume: 28
Issue: 2
Pages: 551-564
ISSN: 0954-5794 (ISSN-L)
1469-2198
DOI: 10.1017/s0954579415000589
PMC: PMC4723293
OpenAlex: W1940341044
Semantic Scholar: 380ed9f55a8cd7ae7c3620e164c6fe368aef9613
Cited by: 27
References: 128
Citations by year: 2026: 1 · 2024: 2 · 2023: 5 · 2022: 3 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 2
FWCI: 0.83
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.cambridge.org/core/terms (unspecified)
Locations: Development and Psychopathology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (UL1TR000005)
National Institute of Mental Health (MH083035, R21MH083035, K08MH100267)
National Center for Research Resources (UL1RR024153)
National Center for Advancing Translational Sciences
Topics: Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Social Sciences › Safety Research › Child Welfare and Adoption
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: child abuse, early trauma, resting-state brain activity, wakefulness, orbitofrontal cortex, hippocampus, military veterans, executive function, social-emotional functioning, sleep-wake regulation, lifespan development, neurobiology of trauma
MeSH terms: Adult, Cognition, Female, Frontal Lobe, Hippocampus, Humans, Male, Nerve Net, Wakefulness, Adult Survivors of Child Abuse, Young Adult, Executive Function, Neuroimaging

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Childhood maltreatment is associated with altered frontolimbic neurobiological activity during wakefulness in adulthood

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