The DOI matches its Crossref record; 45 of the 47 references it cites were found in a registry or an index.
Sexual Dysfunction in Major Depression
Abstract
Little is known about the prevalence, typology, and natural course of non—drug-induced sexual dysfunction in patients with depression. Loss of libido has been reported in various studies to affect from 25% to 75% of patients with unipolar depression, and its prevalence appears to be correlated with the severity of depression. Disorders of arousal also appear to be relatively common in both men and women with major depression, of whom ~25% may experience problems with erection or lubrication. The scant available data regarding orgasmic difficulties in patients with depression who have not yet taken antidepressant medication suggest that they are more common than in the general population. The potential causes of sexual dysfunction in patients with depression are complex and little investigated, and future research must distinguish and explore the various biological, psychological, and psychosocial factors that are likely to be involved.
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“Approximately 25% of patients with major depression may experience problems with erection or lubrication (531).”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [531]
Citations
Cites
Sexual Dysfunction in the United States: Prevalence and Predictors
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Risk for New Onset of Depression During the Menopausal Transition
Cohen, L. S., Soares, C. N., Vitonis, A. F., Otto, M. W., & Harlow, B. L. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.4.385 · Cited by 852
Distress about sex: a national survey of women in heterosexual relationships.
Bancroft, J., Loftus, J., & Long, J. S. (2003) · Archives of Sexual Behavior · doi:10.1023/a:1023420431760 · Cited by 774
Factors predisposing women to chronic pelvic pain: systematic review
Latthe, P. M., Mignini, L. E., Gray, R. G., Hills, R. K., & Khan, K. S. (2006) · BMJ · doi:10.1136/bmj.38748.697465.55 · Cited by 591
Araujo, A. B., Durante, R., Feldman, H. A., Goldstein, I., & McKinlay, J. B. (1998) · Psychosomatic Medicine · doi:10.1097/00006842-199807000-00011 · Cited by 576
Incidence and prevalence of the sexual dysfunctions: A critical review of the empirical literature
Spector, I. P., & Carey, M. P. (1990) · Archives of Sexual Behavior · doi:10.1007/bf01541933 · Cited by 557
Sexual dysfunction before antidepressant therapy in major depression
Kennedy, S. H., Dickens, S. E., Eisfeld, B. S., & Bagby, R. M. (1999) · Journal of Affective Disorders · doi:10.1016/s0165-0327(99)00050-6 · Cited by 412
Sexuality during pregnancy and after childbirth
von Sydow, K. (1999) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(98)00106-8 · Cited by 381
Jackson, S. W. (1986) · Yale University Press eBooks · doi:10.2307/j.ctt1xp3stn · Cited by 335
Research works printed but not linked: 1
- 1994, Diagnostic and Statistical Manual of Mental Disorders
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Items 101–107 of 107
Sexual dysfunction on the background of antidepressant therapy
Петрова, Н. Н. (2023) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro2023123112115
Palomo, A. G., & Hernández, A. B. (2024) · Trends in andrology and sexual medicine · doi:10.1007/978-3-031-55080-5_27
Effects of Psychoactive Plants on Male Sexual Function
Babalola, O. O., & Fasakin, O. W. (2025) · Journal of Psychosexual Health · doi:10.1177/26318318251316089
“11 Even in the absence of syndromal depression, ED is frequently associated with depressive symptoms.”
Reutimann, S., Steiner, J., Hübscher, N., Voderholzer, U., Meule, A., & Augsburger, M. (2025) · JMIR Formative Research · doi:10.2196/50504
“Their prevalences are correlated with the severity of depression [59,61], and acute suicidality is mainly an indication for treatment in a psychiatric clinic.”
Griffioen, J. G., & Bijzitter, G. G. R. (2025) · doi:10.1007/978-90-368-3192-5_13
Keshavarzi, A., Arandi, S. Z., Ahmadpanah, M., Haghighi, M., Jahangard, L., Soltanian, A., Hormoz, N., & Brand, S. (2026) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2026.05.010
Rod, A. (2014) · NORA - Norwegian Open Research Archives
Metadata
- Authors
- Williams, K., & Reynolds, M. F.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Williams, Katherine
- ORCID
- Williams, Katherine
- Venue
- CNS Spectrums
- Publisher
- Cambridge University Press (CUP)
- Published
- 2006
- Volume
- 11
- Issue
- S9
- Pages
- 19-23
- ISSN
- 1092-8529 (ISSN-L)
- 2165-6509
- OpenAlex
- W125145245
- Cited by
- 107
- References
- 47
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 5 · 2023: 9 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 7 · 2017: 3 · 2016: 5 · 2015: 6 · 2014: 6 · 2013: 6 · 2012: 2
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- CNS Spectrums (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Social Sciences › Psychology › Clinical Psychology › Sexuality, Behavior, and Technology
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- sexual dysfunction, major depressive disorder, low libido, arousal disorders, erectile dysfunction, dyspareunia, orgasmic dysfunction, depression severity, prevalence, psychosocial factors, biological factors
- MeSH terms
- Antidepressive Agents, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Erectile Dysfunction, Male, Sexual Dysfunction, Physiological, Prevalence, Sexual Dysfunctions, Psychological
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